WormBase Tree Display for Gene: WBGene00001535
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| WBGene00001535 | SMap | S_parent | Sequence | C49H3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gcy-8 | Person_evidence | WBPerson655 | |||||
| Sequence_name | C49H3.1 | ||||||||
| Molecular_name | C49H3.1 | ||||||||
| C49H3.1.1 | |||||||||
| CE42080 | |||||||||
| Other_name | CELE_C49H3.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | gcy-8 | ||||||||
| DB_info | Database | AceView | gene | 4I697 | |||||
| WormQTL | gene | WBGene00001535 | |||||||
| WormFlux | gene | WBGene00001535 | |||||||
| NDB | locus_tag | CELE_C49H3.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001535|UniProtKB=Q9GYQ4 | |||||||
| family | PTHR11920 | ||||||||
| NCBI | gene | 177584 | |||||||
| RefSeq | protein | NM_068923.7 | |||||||
| KEGG | KEGG_id | 4.6.1.2 | |||||||
| NemaPath | KEGG_id | 4.6.1.2 | |||||||
| SwissProt | UniProtAcc | Q9GYQ4 | |||||||
| TREEFAM | TREEFAM_ID | TF351401 | |||||||
| UniProt_GCRP | UniProtAcc | Q9GYQ4 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gcy | ||||||||
| Allele (54) | |||||||||
| Legacy_information | [Yu S] gcy for Guanylyl CYclase. No mutations known. gcy-8::GFP expressed only in AFD. Predicted gene C49H3.2 | ||||||||
| Strain | WBStrain00031124 | ||||||||
| WBStrain00031127 | |||||||||
| WBStrain00031134 | |||||||||
| WBStrain00022003 | |||||||||
| WBStrain00022015 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (38) | |||||||||
| Ortholog (35) | |||||||||
| Paralog (37) | |||||||||
| Structured_description | Concise_description | gcy-8 encodes a receptor-type guanylyl cyclase that, along with gcy-18 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-8 functions redundantly with gcy-18 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; GCY-8 is expressed exclusively in the AFD thermosensory neurons where it localizes to sensory endings; GCY-8 expression in the AFD neurons requires activity of the TAX-2/4 cyclic nucleotide gated channel and the CMK-1 Ca2+/calmodulin-dependent protein kinase I, while maintenance of GCY-8 expression requires the OTD/OTX homeodomain protein TTX-1. | Paper_evidence | WBPaper00002839 | |||||
| WBPaper00004879 | |||||||||
| WBPaper00006343 | |||||||||
| WBPaper00027040 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables guanylate cyclase activity. Involved in microvillus organization and response to temperature stimulus. Located in microvillus membrane and neuron projection terminus. Expressed in AFDL and AFDR. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C49H3.1 | |||||||
| Corresponding_CDS_history | C49H3.1:wp187 | ||||||||
| Corresponding_transcript | C49H3.1.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf646129 | ||||||||
| WBsf980902 | |||||||||
| WBsf980903 | |||||||||
| WBsf228598 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00042833 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00012164 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103221 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012161 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029995 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042832 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (41) | |||||||||
| Construct_product | WBCnstr00011696 | ||||||||
| WBCnstr00018503 | |||||||||
| WBCnstr00036879 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (102) | |||||||||
| Interaction | WBInteraction000003457 | ||||||||
| WBInteraction000003838 | |||||||||
| WBInteraction000003841 | |||||||||
| WBInteraction000028205 | |||||||||
| WBInteraction000028206 | |||||||||
| WBInteraction000028207 | |||||||||
| WBInteraction000030134 | |||||||||
| WBInteraction000165818 | |||||||||
| WBInteraction000165819 | |||||||||
| WBInteraction000165820 | |||||||||
| WBInteraction000500833 | |||||||||
| WBInteraction000500834 | |||||||||
| WBInteraction000501487 | |||||||||
| WBInteraction000501488 | |||||||||
| WBInteraction000501489 | |||||||||
| WBInteraction000501709 | |||||||||
| WBInteraction000501958 | |||||||||
| WBInteraction000501959 | |||||||||
| WBInteraction000501960 | |||||||||
| WBInteraction000503642 | |||||||||
| WBInteraction000524549 | |||||||||
| WBInteraction000524659 | |||||||||
| WBInteraction000525000 | |||||||||
| WBInteraction000556123 | |||||||||
| WBInteraction000556124 | |||||||||
| WBInteraction000556854 | |||||||||
| WBInteraction000556855 | |||||||||
| WBInteraction000556859 | |||||||||
| WBInteraction000556860 | |||||||||
| WBInteraction000556861 | |||||||||
| Map_info | Map | IV | Position | 3.50015 | Error | 0.000609 | |||
| Positive | Positive_clone | C49H3 | Person_evidence | WBPerson4049 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4941 | |||||||
| Pseudo_map_position | |||||||||
| Reference (72) | |||||||||
| Remark | Data extracted from Yu et al. (1997) | ||||||||
| C49H3.2 is dead merged into .1 [sdm 11.2000] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
