WormBase Tree Display for Gene: WBGene00000879
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| WBGene00000879 | SMap | S_parent | Sequence | Y75B12B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyn-3 | Person_evidence | WBPerson466 | |||||
| Sequence_name | Y75B12B.5 | ||||||||
| Molecular_name | Y75B12B.5 | ||||||||
| Y75B12B.5.1 | |||||||||
| CE20374 | |||||||||
| Other_name | cyp-3 | Person_evidence | WBPerson466 | ||||||
| CELE_Y75B12B.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | cyn-3 | ||||||||
| DB_info | Database | AceView | gene | 5P671 | |||||
| WormQTL | gene | WBGene00000879 | |||||||
| WormFlux | gene | WBGene00000879 | |||||||
| NDB | locus_tag | CELE_Y75B12B.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000879|UniProtKB=P52011 | |||||||
| family | PTHR11071 | ||||||||
| NCBI | gene | 180028 | |||||||
| RefSeq | protein | NM_074350.9 | |||||||
| KEGG | KEGG_id | 5.2.1.8 | |||||||
| NemaPath | KEGG_id | 5.2.1.8 | |||||||
| SwissProt | UniProtAcc | P52011 | |||||||
| TREEFAM | TREEFAM_ID | TF312801 | |||||||
| UniProt_GCRP | UniProtAcc | P52011 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 Sep 2004 16:20:03 | WBPerson1971 | Name_change | CGC_name | cyp-3 -> cyn-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyn | ||||||||
| Allele (28) | |||||||||
| Legacy_information | [C.elegansII] NMK. Cyclophilin family, transspliced to SL1. YAC Y15F7. [TP] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Contained_in_operon | CEOP5521 | ||||||||
| Ortholog (54) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | cyn-3 encodes an abundantly expressed cyclophilin A isoform with peptidyl-prolyl isomerase activity in vitro, which closely resembles the prototypical CypA and is thus likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; cyn-3 is exclusively expressed in the single anterior excretory cell, and is dispensable for viability and gross morphology in mass RNAi screens. | Paper_evidence | WBPaper00002472 | |||||
| WBPaper00003820 | |||||||||
| WBPaper00005654 | |||||||||
| WBPaper00026884 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Mar 2007 00:00:00 | ||||||||
| Automated_description | Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in obsolete cell. Expressed in excretory system. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
| DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:1474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:12506 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| Molecular_info | Corresponding_CDS | Y75B12B.5 | |||||||
| Corresponding_transcript | Y75B12B.5.1 | ||||||||
| Other_sequence (202) | |||||||||
| Associated_feature | WBsf647585 | ||||||||
| WBsf977375 | |||||||||
| WBsf977376 | |||||||||
| WBsf1002255 | |||||||||
| WBsf1002256 | |||||||||
| WBsf1020992 | |||||||||
| WBsf233011 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00076847 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00021430 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058423 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027819 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr984 | ||||||||
| Expr985 | |||||||||
| Expr1018223 | |||||||||
| Expr1030544 | |||||||||
| Expr1161844 | |||||||||
| Expr2010671 | |||||||||
| Expr2028911 | |||||||||
| Drives_construct | WBCnstr00013833 | ||||||||
| WBCnstr00037227 | |||||||||
| Construct_product | WBCnstr00013833 | ||||||||
| WBCnstr00037227 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction | WBInteraction000037117 | ||||||||
| WBInteraction000037121 | |||||||||
| WBInteraction000037125 | |||||||||
| WBInteraction000037126 | |||||||||
| WBInteraction000037127 | |||||||||
| WBInteraction000042209 | |||||||||
| WBInteraction000048834 | |||||||||
| WBInteraction000143311 | |||||||||
| WBInteraction000157024 | |||||||||
| WBInteraction000157059 | |||||||||
| WBInteraction000157955 | |||||||||
| WBInteraction000157966 | |||||||||
| WBInteraction000158359 | |||||||||
| WBInteraction000159054 | |||||||||
| WBInteraction000159066 | |||||||||
| WBInteraction000159072 | |||||||||
| WBInteraction000159087 | |||||||||
| WBInteraction000159133 | |||||||||
| WBInteraction000159356 | |||||||||
| WBInteraction000159472 | |||||||||
| WBInteraction000169943 | |||||||||
| WBInteraction000174502 | |||||||||
| WBInteraction000183657 | |||||||||
| WBInteraction000184828 | |||||||||
| WBInteraction000187489 | |||||||||
| WBInteraction000189574 | |||||||||
| WBInteraction000189633 | |||||||||
| WBInteraction000193390 | |||||||||
| WBInteraction000199109 | |||||||||
| WBInteraction000223539 | |||||||||
| WBInteraction000252160 | |||||||||
| WBInteraction000256493 | |||||||||
| WBInteraction000258915 | |||||||||
| WBInteraction000258937 | |||||||||
| WBInteraction000259137 | |||||||||
| WBInteraction000259728 | |||||||||
| WBInteraction000261803 | |||||||||
| WBInteraction000268528 | |||||||||
| WBInteraction000281060 | |||||||||
| WBInteraction000281061 | |||||||||
| WBInteraction000289014 | |||||||||
| WBInteraction000295465 | |||||||||
| WBInteraction000311181 | |||||||||
| WBInteraction000311786 | |||||||||
| WBInteraction000330112 | |||||||||
| WBInteraction000331973 | |||||||||
| WBInteraction000338799 | |||||||||
| WBInteraction000340860 | |||||||||
| WBInteraction000340869 | |||||||||
| WBInteraction000341118 | |||||||||
| WBInteraction000341138 | |||||||||
| WBInteraction000341164 | |||||||||
| WBInteraction000341380 | |||||||||
| WBInteraction000355708 | |||||||||
| WBInteraction000359450 | |||||||||
| WBInteraction000362808 | |||||||||
| WBInteraction000372013 | |||||||||
| WBInteraction000372818 | |||||||||
| WBInteraction000379834 | |||||||||
| WBInteraction000380147 | |||||||||
| WBInteraction000385744 | |||||||||
| WBInteraction000390091 | |||||||||
| WBInteraction000394627 | |||||||||
| WBInteraction000396793 | |||||||||
| WBInteraction000398473 | |||||||||
| WBInteraction000403682 | |||||||||
| WBInteraction000407721 | |||||||||
| WBInteraction000409363 | |||||||||
| WBInteraction000430084 | |||||||||
| WBInteraction000432925 | |||||||||
| WBInteraction000435796 | |||||||||
| WBInteraction000444008 | |||||||||
| WBInteraction000451222 | |||||||||
| WBInteraction000453736 | |||||||||
| WBInteraction000457217 | |||||||||
| WBInteraction000463033 | |||||||||
| WBInteraction000463649 | |||||||||
| WBInteraction000464142 | |||||||||
| WBInteraction000464880 | |||||||||
| WBInteraction000467515 | |||||||||
| WBInteraction000468131 | |||||||||
| WBInteraction000468958 | |||||||||
| WBInteraction000469052 | |||||||||
| WBInteraction000471674 | |||||||||
| WBInteraction000472347 | |||||||||
| WBInteraction000472356 | |||||||||
| WBInteraction000473133 | |||||||||
| WBInteraction000473581 | |||||||||
| WBInteraction000473846 | |||||||||
| WBInteraction000474638 | |||||||||
| WBInteraction000548427 | |||||||||
| WBInteraction000554600 | |||||||||
| WBInteraction000555878 | |||||||||
| WBInteraction000558936 | |||||||||
| WBInteraction000559692 | |||||||||
| WBInteraction000560890 | |||||||||
| WBInteraction000562266 | |||||||||
| WBInteraction000563160 | |||||||||
| WBInteraction000565074 | |||||||||
| WBInteraction000565103 | |||||||||
| WBInteraction000571964 | |||||||||
| WBInteraction000573389 | |||||||||
| WBInteraction000577524 | |||||||||
| WBInteraction000579930 | |||||||||
| WBInteraction000582650 | |||||||||
| Map_info | Map | V | Position | 7.54862 | Error | 0.006411 | |||
| Positive | Positive_clone | Y15F7 | Author_evidence | Page AM | |||||
| Y75B12B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| ZK526 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00002472 | ||||||||
| WBPaper00003820 | |||||||||
| WBPaper00018604 | |||||||||
| WBPaper00026884 | |||||||||
| WBPaper00032230 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | [Page AM] Is transpliced by SL-1. Isolated from mixed stage cDNA by A. P. Page using SL1, and known 3' seq from CEESH95F. (not mapped); Genbank U31077. | ||||||||
| [JAH]Partial sequence identity 64% to human CYP gene, 66% to yeast CSBY. | |||||||||
| CEESH95F,CEMSB85F,CEMSB85FB,CEMSB85R removed from sequence list and replaced by genomic_canonical Y75B12B.5. sdm 11/00 | |||||||||
| PPIase or cyclophilin, EC 5.2.1.8 | |||||||||
| This gene has been renamed with approval of the CGC (cyp-3->cyn-3) | Person_evidence | WBPerson466 | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
