WormBase Tree Display for Gene: WBGene00020268

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WBGene00020268	SMap	S_parent	Sequence	T05H4
	Identity	Version	2
		Name	CGC_name	hpo-19	Paper_evidence	WBPaper00038231
					Person_evidence	WBPerson26
			Sequence_name	T05H4.5
			Molecular_name	T05H4.5
				T05H4.5.1
				CE13277
			Other_name	CELE_T05H4.5	Accession_evidence	NDB	BX284605
			Public_name	hpo-19
		DB_info	Database	AceView	gene	5G917
				WormQTL	gene	WBGene00020268
				WormFlux	gene	WBGene00020268
				NDB	locus_tag	CELE_T05H4.5
				Panther	gene	CAEEL\|WormBase=WBGene00020268\|UniProtKB=O16521
					family	PTHR19370
				NCBI	gene	179029
				RefSeq	protein	NM_072237.7
				KEGG	KEGG_id	1.6.2.2
				NemaPath	KEGG_id	1.6.2.2
				TREEFAM	TREEFAM_ID	TF314333
				TrEMBL	UniProtAcc	O16521
				UniProt_GCRP	UniProtAcc	O16521
		Species	Caenorhabditis elegans
		History	Version_change	1	28 May 2004 13:31:02	WBPerson1971	Event	Imported	Initial conversion from CDS class of stlace from WS125
				2	26 Apr 2011 13:31:47	WBPerson2970	Name_change	CGC_name	hpo-19
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	hpo
		Allele (34)
		RNASeq_FPKM (74)
		GO_annotation	00028233
			00028234
			00028235
			00028236
			00028237
			00028238
			00124939
		Contained_in_operon	CEOP5112
		Ortholog (50)
		Paralog	WBGene00020267	Caenorhabditis elegans	From_analysis	TreeFam
						Inparanoid_8
						Panther
						WormBase-Compara
			WBGene00013123	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	The T05H4.5 gene encodes an ortholog of the human gene NADH-CYTOCHROME B5 REDUCTASE (DIA1), which when mutated leads to methemoglobinemia (OMIM:250800).	Paper_evidence	WBPaper00004637
					Curator_confirmed	WBPerson1823
						WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Predicted to enable FAD binding activity. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in estrogen-receptor negative breast cancer and methemoglobinemia. Is an ortholog of human CYB5R1 (cytochrome b5 reductase 1); CYB5R2 (cytochrome b5 reductase 2); and CYB5R3 (cytochrome b5 reductase 3).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:0060076	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2873)
			DOID:10783	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2873)
			DOID:1612	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2873)
	Molecular_info	Corresponding_CDS	T05H4.5
		Corresponding_transcript	T05H4.5.1
		Other_sequence (25)
		Associated_feature	WBsf646879
			WBsf661336
			WBsf231879
	Experimental_info	RNAi_result	WBRNAi00009126	Inferred_automatically	RNAi_primary
			WBRNAi00026207	Inferred_automatically	RNAi_primary
			WBRNAi00052592	Inferred_automatically	RNAi_primary
			WBRNAi00088747	Inferred_automatically	RNAi_primary
			WBRNAi00088640	Inferred_automatically	RNAi_primary
			WBRNAi00090940	Inferred_automatically	RNAi_primary
			WBRNAi00071536	Inferred_automatically	RNAi_primary
			WBRNAi00035243	Inferred_automatically	RNAi_primary
			WBRNAi00111686	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1021433
			Expr1038824
			Expr1156206
			Expr2012561
			Expr2030798
		Drives_construct	WBCnstr00025251
		Construct_product	WBCnstr00025251
		Microarray_results (23)
		Expression_cluster	WBPaper00005700:transmembrane_protein
			WBPaper00028451:Low_abundance_spermatogenesis_enriched
			WBPaper00032097:CGH-1-associated-mRNA
			WBPaper00032528:L3_enriched
			WBPaper00033070:Elbe_downregulated
			WBPaper00033070:Rhine_downregulated
			WBPaper00035073:mitochondria_protein
			WBPaper00036375:enriched_in_PVD_OLL
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00038118:aak-2(gt33)_upregulated
			WBPaper00038168:lin-35_downregulated
			WBPaper00038289:oocyte_protein
			WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
			WBPaper00040965:lipid-droplet_associated_protein
			WBPaper00044426:rotenone_24h_upregulated
			WBPaper00044501:gld-1_let-7_regulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044746:aging_downregulated_HeatShock
			WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
			WBPaper00045521:Gender_Neutral
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
			WBPaper00048923:Aging_regulated
			WBPaper00048988:neuron_expressed
			WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
			WBPaper00049942:hsf-1(RNAi)_downregulated
			WBPaper00050488:20C_vs_25C_regulated_N2_adult
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:arcade_intestinal-valve_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00050990:seam_expressed
			WBPaper00051039:intestine_enriched
			WBPaper00051245:body-wall-muscle_cytoplasm_expressed
			WBPaper00051245:epidermis_cytoplasm_expressed
			WBPaper00051245:intestine_cytoplasm_expressed
			WBPaper00051558:aging_regulated
			WBPaper00053615:SMO-1_target
			WBPaper00053810:nuo-6(qm200)_upregulated
			WBPaper00055049:S.gordonii_downregulated
			WBPaper00055862:antimycin_damt-1(gk961032)_regulated
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00056443:sek-1(km4)_downregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00056471:S.aureus-4h_downregulated_N2
			WBPaper00056809:smn-1(ok355)_downregulated
			WBPaper00057288:iff-1(RNAi)_upregulated_transcript
			WBPaper00058958:100mGy-irradiation-72h_downregulated
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
			WBPaper00059605:MUT-16_interacting
			WBPaper00059895:wounding_downregulated
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00061341:28C_48h_downregulated
			WBPaper00061478:SUMO-conjugated_protein
			WBPaper00061527:F31C3.4_6048-cutc-1_15804
			WBPaper00062325:etr-1(lq61)_downregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00062498:PPM-1.D_interacting
			WBPaper00062554:MAGU-2_interacting
			WBPaper00062669:extracellular-vesicle_protein
			WBPaper00064055:trl-1(cas1077)_downregulated_starved
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
			WBPaper00064716:paraquat_downregulated
			WBPaper00064871:hypoxia_upregulated_F1
			WBPaper00065086:JU1400_N.ferruginous_regulated
			WBPaper00065120:body-muscle-transcriptome
			WBPaper00065373:sek-1(km4)_downregulated_cisplatin
			cgc4386_cluster_2_2
			cgc4489_group_3
			WBPaper00005124:estrogen_10-5M_regulated
			WBPaper00025032:cluster_8
			WBPaper00025099:MA_specific
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00026980:intestine_enriched
			WBPaper00030839:Embryo_Pan_Neuronal
			WBPaper00031532:Larva_Pan_Neuronal_Depleted
			WBPaper00035905:FBF-1_Associated
			WBPaper00036286:Pattern_H
			WBPaper00037901:GLD-1_mRNA_targets
			WBPaper00038231:Cry5B_1.5-fold_downregulated
			WBPaper00038231:Cry5B_2-fold_downregulated
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00041606:CE_S.marcescens_regulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00045263:nuo-6(qm200)_upregulated
			WBPaper00045960:L1-L4-lethargus_downregulated
			WBPaper00045960:L4-lethargus_downregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00053236:Starvation_regulated_N2
			[cgc5767]:cluster_1
			[cgc5767]:expression_class_E
			[cgc5767]:expression_class_E_pi(186_min)
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_MD
			[cgc5767]:expression_class_MD_pd(23_min)
			[cgc5767]:expression_class_ME
		Interaction (65)
	Map_info	Map	V	Position	-0.168074	Error	0.002349
		Positive	Positive_clone	T05H4	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference	WBPaper00038491
		WBPaper00049152
		WBPaper00055090
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene