WormBase Tree Display for Gene: WBGene00011067

WBGene00011067 SMap: S_parent: Sequence: R06F6
  Identity: Version: 2
    Name: CGC_name: vps-11 Paper_evidence: WBPaper00031805
      Sequence_name: R06F6.2
      Molecular_name: R06F6.2
        R06F6.2.1
        CE43323
      Other_name: CELE_R06F6.2 Accession_evidence: NDB BX284602
      Public_name: vps-11
    DB_info: Database: AceView gene 2L78
        WormQTL gene WBGene00011067
        WormFlux gene WBGene00011067
        NDB locus_tag CELE_R06F6.2
        Panther gene CAEEL|WormBase=WBGene00011067|UniProtKB=Q09600
          family PTHR23323
        NCBI gene 174661
        RefSeq protein NM_063921.7
        SwissProt UniProtAcc Q09600
        TREEFAM TREEFAM_ID TF300479
        UniProt_GCRP UniProtAcc Q09600
        OMIM gene 608549
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 29 Apr 2008 17:17:15 WBPerson2970 Name_change: CGC_name: vps-11
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vps
    Allele (83)
    Strain: WBStrain00032155
    RNASeq_FPKM (74)
    GO_annotation (19)
    Contained_in_operon: CEOP2504
    Ortholog (35)
    Paralog: WBGene00021058 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in organelle organization and vesicle docking involved in exocytosis. Predicted to be located in endosome. Predicted to be part of HOPS complex. Expressed in gonad. Human ortholog(s) of this gene implicated in dystonia and hypomyelinating leukodystrophy 12. Is an ortholog of human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060796 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14583)
      DOID:543 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14583)
  Molecular_info: Corresponding_CDS: R06F6.2
    Corresponding_CDS_history: R06F6.2:wp197
    Corresponding_transcript: R06F6.2.1
    Other_sequence (20)
    Associated_feature: WBsf666063
      WBsf989485
      WBsf223834
      WBsf223835
      WBsf223836
      WBsf223837
  Experimental_info: RNAi_result (32)
    Expr_pattern: Expr4024
      Expr1027953
      Expr1034861
      Expr1155085
      Expr2018009
      Expr2036146
    Drives_construct: WBCnstr00030958
    Construct_product: WBCnstr00030958
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-35_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058969:RIS_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:Coelomocyte
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061527:mbk-2_1585-tol-1_22538
      WBPaper00061527:tag-266-cand-1_14017
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      cgc4489_group_2
      cgc4489_group_13
      WBPaper00006465:IV_ethanol_late_repression
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027758:Group_IV
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2lessDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_A
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (41)
  Map_info: Map: II Position: 3.12698 Error: 5.7e-05
    Positive: Positive_clone: R06F6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027315
    WBPaper00031805
    WBPaper00032272
    WBPaper00034662
    WBPaper00035228
    WBPaper00036342
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene