WormBase Tree Display for Gene: WBGene00001828

WBGene00001828 SMap: S_parent: Sequence: F40E10
  Identity: Version: 1
    Name: CGC_name: hch-1 Person_evidence: WBPerson261
      Sequence_name: F40E10.1
      Molecular_name: F40E10.1
        F40E10.1.1
        CE24964
      Other_name: nas-34 CGC_data_submission
        CELE_F40E10.1 Accession_evidence: NDB BX284606
      Public_name: hch-1
    DB_info: Database: AceView gene XP316
        WormQTL gene WBGene00001828
        WormFlux gene WBGene00001828
        NDB locus_tag CELE_F40E10.1
        Panther gene CAEEL|WormBase=WBGene00001828|UniProtKB=Q21059
          family PTHR10127
        NCBI gene 181564
        RefSeq protein NM_078039.7
        KEGG KEGG_id 3.4.24.-
        NemaPath KEGG_id 3.4.24.-
        SwissProt UniProtAcc Q21059
        UniProt_GCRP UniProtAcc Q21059
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hch
    Allele (66)
    Legacy_information: e1734 : delayed hatching from eggshell rescued by protease or wildtype hatching fluid; QL and descendant cells migrate forward instead of backward. ES1. NA2 (e1907 : same phenotypes).
      See also e1734, e1907
      [C.elegansII] e1734 : delayed hatching from eggshell rescued by protease or wildtype hatching fluid; QL and descendant cells migrate forward instead of backward. ES1. OA1: e1907 (same phenotypes). [Hedgecock et al. 1987; NJ]
    Strain: WBStrain00022188
      WBStrain00028851
      WBStrain00032580
      WBStrain00004447
    RNASeq_FPKM (74)
    GO_annotation: 00070204
      00070205
      00070206
      00070207
      00070208
      00070209
      00070210
      00070211
      00070212
      00070213
      00109454
      00109455
      00109456
      00109457
      00109458
    Ortholog (29)
    Paralog (48)
    Structured_description: Concise_description: hch-1 encodes a member of the zinc-dependent metalloprotease family that contains an epidermal growth factor-like domain, a CUB domain, and a TSP1 domain and affects hatching and QL neuroblast migration. Paper_evidence: WBPaper00002539
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase activity. Involved in hatching and neuron migration. Predicted to be located in extracellular region. Expressed in hypodermis and seam cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F40E10.1
    Corresponding_transcript: F40E10.1.1
    Other_sequence (21)
    Associated_feature: WBsf654592
      WBsf671285
      WBsf671286
      WBsf671287
      WBsf671288
      WBsf1007977
      WBsf1007978
      WBsf1024444
      WBsf1024445
      WBsf238245
  Experimental_info: RNAi_result (13)
    Expr_pattern: Expr1567
      Expr1568
      Expr4066
      Expr1028021
      Expr1031073
      Expr1150707
      Expr2012376
      Expr2030612
    Drives_construct: WBCnstr00010336
      WBCnstr00036663
    Construct_product: WBCnstr00036663
    Antibody: WBAntibody00000127
    Microarray_results (19)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00030922:glycosylated_protein
      WBPaper00032976:non_compensated_genes
      WBPaper00034636:heat_shock_upregulated
      WBPaper00036231:long-telomeres_upregulated
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00042561:smg-2(RNAi)_downregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044760:somatic_specific
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00046805:csr-1(RNAi)_downregulated_Set2
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048926:miaserin_upregulated_adult-day10
      WBPaper00049498:npr-1(ur89)_regulated_4
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049954:BPS_upregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00051265:F1_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051305:vit-2(ac3)_upregulated
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052856:Cadmium_regulated
      WBPaper00053020:sid-3(ok973)_downregulated
      WBPaper00053020:sta-1(ok587)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00055981:fog-2(q71)_downregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056039:ptrn-1(tm5597)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-8(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056446:hsb-1(cg116)_upregulated
      WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_downregulated
      WBPaper00057149:prgn-1(tm985)_downregulated
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00057265:metaformin_upregulated_OP50-MR
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059224:serotonin_downregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059231:alh-6(lax105)_D3Adult_downregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_upregulated_N2
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060224:atf-6(ok551)_upregulated
      WBPaper00060445:nfki-1(cer1)_downregulated_L1
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060886:met-2(n4256)_upregulated
      WBPaper00060921:tph-1(mg280)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:P_cell
      WBPaper00061340:Seam_cell
      WBPaper00061340:T
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:F58E6.13_17427-ifa-3
      WBPaper00061853:osm-3(dh441)_upregulated
      WBPaper00061853:osm-3(dh441)_upregulated_tunicamycin
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062491:sma-3(wk30)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:115_0
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:Doxorubicin_downregulated_tetraploid
      WBPaper00066204:CdCl2_downregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_upregulated_WT
      WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_6_1
      cgc4489_group_21
      WBPaper00013462:daf-2_age_regulated
      WBPaper00025032:cluster_37
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027758:Group_III
      WBPaper00029437:dcr-1_upregulated
      WBPaper00032948:FedUp
      WBPaper00033101:spr-5_regulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00036286:Pattern_B
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00039866:SAM_daf-19_upregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00046639:tyrosol_upregulated
      WBPaper00047021:MWCNT_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00050767:Octopamine_induced
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:cluster_12
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(186_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(186_min)
    Interaction (133)
  Map_info: Map: X Position: 20.1076 Error: 0.039509
    Positive: Positive_clone: F40E10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 582
        583
        3540
        3541
        4664
        5528
  Reference (16)
  Method: Gene