WormBase Tree Display for Gene: WBGene00006802
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WBGene00006802 | SMap | S_parent | Sequence | T07A5 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | unc | |||||
Reference_allele | WBVar00143321 | |||||
Allele (18) | ||||||
Legacy_information | e587 : medium coiler inactive small; abnormalities in VD and DD commissures. ES3 ME0. NA2 (e602). | |||||
[C.elegansII] e587 : medium coiler, inactive, small; abnormalities in VD and DD commissures, longitudinal axon elongation. ES3 ME0. OA1: e602. Cloned: cosmid rescue (C46D2). [Brenner 1974; NG; SQ; WS] | ||||||
Strain (16) | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation | 00005135 | |||||
00005136 | ||||||
00005137 | ||||||
00005138 | ||||||
00005139 | ||||||
00005140 | ||||||
00005141 | ||||||
00005142 | ||||||
00005143 | ||||||
Ortholog (36) | ||||||
Structured_description | Concise_description | unc-69 encodes, by alternative splicing, three isoforms of a small (102- to 176-residue) coiled-coil protein required for normal axonal extension, axonal guidance, neuronal fasciculation, and synaptic vesicle localization; UNC-69 is orthologous to human SCOCO, which can transgenically rescue the locomotion defect of strong unc-69 mutants; UNC-69 is expressed in embryos, the processes and growth cones of immature neurons, and in the cell bodies of many (perhaps all) mature neurons; UNC-69 acts cell-autonomously in at least touch neurons, and perhaps all neurons; since UNC-69 binds a 19-residue conserved coiled-coil domain of UNC-76, UNC-69 and UNC-76 colocalize to neuronal puncta, unc-69 mutants phenotypically resemble unc-76, and mutations of these genes have nonallelic noncomplementation, UNC-69 and UNC-76 are likely to function as a complex. | Paper_evidence | WBPaper00000031 | ||
WBPaper00001345 | ||||||
WBPaper00002837 | ||||||
WBPaper00027646 | ||||||
WBPaper00027651 | ||||||
WBPaper00031100 | ||||||
Curator_confirmed | WBPerson1843 | |||||
WBPerson567 | ||||||
Date_last_updated | 18 Oct 2007 00:00:00 | |||||
Automated_description | Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in CAN; HSN; ganglia; somatic nervous system; and touch receptor neurons. Is an ortholog of human SCOC (short coiled-coil protein). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | T07A5.6a | ||||
T07A5.6b | ||||||
T07A5.6c | ||||||
Corresponding_transcript | T07A5.6a.1 | |||||
T07A5.6b.1 | ||||||
T07A5.6c.1 | ||||||
Other_sequence (59) | ||||||
Associated_feature | WBsf645555 | |||||
WBsf659491 | ||||||
WBsf981560 | ||||||
WBsf993970 | ||||||
WBsf993971 | ||||||
WBsf993972 | ||||||
WBsf1015766 | ||||||
WBsf1015767 | ||||||
WBsf225701 | ||||||
WBsf225702 | ||||||
WBsf225703 | ||||||
WBsf225704 | ||||||
Experimental_info | RNAi_result | WBRNAi00035291 | Inferred_automatically | RNAi_primary | ||
WBRNAi00062360 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr4900 | |||||
Expr7838 | ||||||
Expr1016022 | ||||||
Expr1032870 | ||||||
Expr1156304 | ||||||
Expr2017899 | ||||||
Expr2036035 | ||||||
Drives_construct | WBCnstr00001400 | |||||
WBCnstr00012320 | ||||||
WBCnstr00012950 | ||||||
Construct_product | WBCnstr00001400 | |||||
WBCnstr00012320 | ||||||
WBCnstr00012950 | ||||||
Microarray_results (25) | ||||||
Expression_cluster (123) | ||||||
Interaction | WBInteraction000008990 | |||||
WBInteraction000522715 | ||||||
WBInteraction000522716 | ||||||
WBInteraction000547046 | ||||||
Map_info (5) | ||||||
Reference (52) | ||||||
Remark | on same cosmid as unc-50; genetic map data indicate unc-69 left of unc-50 JAH 01/01 | |||||
Method | Gene |