WormBase Tree Display for Gene: WBGene00003056
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WBGene00003056 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lon-2 | Person_evidence | WBPerson261 | |||||
Sequence_name | C39E6.1 | ||||||||
Molecular_name | C39E6.1 | ||||||||
C39E6.1.1 | |||||||||
CE35426 | |||||||||
Other_name | CELE_C39E6.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lon-2 | ||||||||
DB_info | Database | AceView | gene | XF356 | |||||
WormQTL | gene | WBGene00003056 | |||||||
WormFlux | gene | WBGene00003056 | |||||||
NDB | locus_tag | CELE_C39E6.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003056|UniProtKB=Q18530 | |||||||
family | PTHR10822 | ||||||||
NCBI | gene | 180750 | |||||||
RefSeq | protein | NM_076411.8 | |||||||
TREEFAM | TREEFAM_ID | TF353541 | |||||||
TrEMBL | UniProtAcc | Q18530 | |||||||
UniProt_GCRP | UniProtAcc | Q18530 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lon | ||||||||
Reference_allele | WBVar00143398 | ||||||||
Allele (213) | |||||||||
Legacy_information (2) | |||||||||
Strain (224) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (18) | |||||||||
Ortholog (25) | |||||||||
Structured_description | Concise_description | lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. | Paper_evidence | WBPaper00029002 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 24 Jan 2007 00:00:00 | ||||||||
Automated_description | Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C39E6.1 | |||||||
Corresponding_CDS_history | C39E6.1:wp107 | ||||||||
Corresponding_transcript | C39E6.1.1 | ||||||||
Other_sequence | CRC07010_1 | ||||||||
CR09868 | |||||||||
CGC00490_1 | |||||||||
CBC13859_1 | |||||||||
CJC03031_1 | |||||||||
CRC04307_1 | |||||||||
Associated_feature | WBsf670454 | ||||||||
WBsf670455 | |||||||||
WBsf670456 | |||||||||
WBsf1005049 | |||||||||
WBsf1005050 | |||||||||
WBsf1005051 | |||||||||
WBsf1005052 | |||||||||
WBsf1005053 | |||||||||
WBsf1005054 | |||||||||
WBsf1005055 | |||||||||
WBsf1005056 | |||||||||
WBsf1022843 | |||||||||
WBsf1022844 | |||||||||
WBsf1022845 | |||||||||
WBsf237316 | |||||||||
Experimental_info (7) | |||||||||
Map_info | Map | X | Position | -6.74013 | Error | 0.007834 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mnDp30 | |||||||
yDp4 | |||||||||
Positive_clone | C39E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
F43C9 | |||||||||
Negative | Outside_rearr | mcDf2 | |||||||
Mapping_data (3) | |||||||||
Landmark_gene | |||||||||
Reference (155) | |||||||||
Remark | sequence wsa incorrectly given as F43C9.3 | ||||||||
Method | Gene |