WormBase Tree Display for Gene: WBGene00000068
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WBGene00000068 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F17C8 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | acy-1 | Person_evidence | WBPerson1139 | |||||
Sequence_name | F17C8.1 | ||||||||
Molecular_name | F17C8.1 | ||||||||
F17C8.1.1 | |||||||||
CE00955 | |||||||||
Other_name | sgs-1 | ||||||||
CELE_F17C8.1 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | acy-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | acy | ||||||||
Allele (122) | |||||||||
Legacy_information | [Berger AJ, Kaplan JM] nu327 is semidominant suppressor of neurodegeneration induced by constitutive G alpha s. No conspicuous behavioral or other phenotype, odorant response to isoamyl alcohol slightly impaired. OA2: nu329, nu343 similar. Encodes adenylyl cyclase, 40% identical to mammalian adenylyl cyclases. nu327 missense, nu329 and nu343 splice donor mutations. Predicted gene F17C8.1 | ||||||||
[Korswagen HC] pk301 (pka sgs-1) suppresses neuronal degeneration induced by activated G alpha s. No obvious defects in development or behavior. Loss-of-function mutation in predicted adenylyl cyclase. OA8: pk310, pk311, pk450::Tc1, etc., all similar. | |||||||||
Strain (14) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (22) | |||||||||
Ortholog (34) | |||||||||
Paralog (36) | |||||||||
Structured_description | Concise_description | acy-1 encodes an adenylyl cyclase that is most closely related to the divergent mouse isoform type IX; acy-1 is required for viability, muscle contraction, locomotion, molting, and regulation of sleep-like behavior (lethargus) during larval development; acy-1 acts genetically downstream of gsa-1 and is expressed in excitable cells. | Paper_evidence | WBPaper00003038 | |||||
WBPaper00003207 | |||||||||
WBPaper00031383 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 06 Nov 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in plasma membrane. Expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in mood disorder. Is an ortholog of human ADCY9 (adenylate cyclase 9). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:3324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:240) | ||||
Molecular_info | Corresponding_CDS | F17C8.1 | |||||||
Corresponding_transcript | F17C8.1.1 | ||||||||
Other_sequence (201) | |||||||||
Associated_feature | WBsf645116 | ||||||||
WBsf645117 | |||||||||
WBsf658856 | |||||||||
WBsf992201 | |||||||||
WBsf992202 | |||||||||
WBsf1014794 | |||||||||
WBsf1014795 | |||||||||
WBsf1014796 | |||||||||
WBsf224787 | |||||||||
WBsf224788 | |||||||||
WBsf224789 | |||||||||
Experimental_info (8) | |||||||||
Map_info | Map | III | Position | -2.649 | Error | 0.036999 | |||
Well_ordered | |||||||||
Positive | Positive_clone | F17C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3712 | |||||||
4625 | |||||||||
Reference (62) | |||||||||
Remark | Data extracted from Berger et al. (1998) | ||||||||
Data extracted from Korswagen et al. (1998) | |||||||||
Sequence connection from [Berger AJ] | |||||||||
Positive_clone F17C8 is based on cosmid rescue, mutant sequence [Berger AJ, Kaplan JM, Korswagen HC][[030403 ck1] | |||||||||
Method | Gene |