plx-2 encodes one of two C. elegans plexins, conserved transmembrane proteins that function as semaphorin receptors in both vertebrates and invertebrates; plx-2 activity is essential for proper male tail and epidermal morphogenesis and for normal axon guidance in a select group of neurons, including SDQL; genetic analyses indicate that plx-2 functions with mab-20/semaphorin-2a, efn-4/ephrin-4, and unc-129/TGF-beta to regulate male tail morphogenesis and with mab-20 and lad-2/L1CAM to mediate axon guidance; PLX-2 can bind MAB-20 and this interaction is enhanced in the presence of LAD-2; PLX-2::GFP reporters are expressed in a subset of neurons and epidermal cells, as well as a subset (1, 3, 5, and 7) of male sensory ray cell clusters.
Enables semaphorin receptor activity. Involved in several processes, including axonal fasciculation; nematode larval development; and nematode male tail tip morphogenesis. Located in cell leading edge and cell surface. Expressed in several structures, including P3/4L; P9/10L; P9/10R; neuroblasts; and ray structural cell.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
[wm99ab616], [wm2001p535], and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog