WormBase Tree Display for Gene: WBGene00000403
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WBGene00000403 | SMap | S_parent | Sequence | B0034 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | casy-1 | Person_evidence | WBPerson284 | |||||
WBPerson481 | |||||||||
Sequence_name | B0034.3 | ||||||||
Molecular_name | B0034.3a | ||||||||
B0034.3a.1 | |||||||||
CE27048 | |||||||||
B0034.3b | |||||||||
CE27049 | |||||||||
B0034.3c | |||||||||
CE39540 | |||||||||
B0034.3d | |||||||||
CE54496 | |||||||||
B0034.3b.1 | |||||||||
B0034.3c.1 | |||||||||
B0034.3d.1 | |||||||||
Other_name | cdh-11 | Person_evidence | WBPerson698 | ||||||
CELE_B0034.3 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | casy-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 05 Jan 2006 11:22:20 | WBPerson2970 | Name_change | CGC_name | casy-1 | ||||
Other_name | cdh-11 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | casy | ||||||||
Allele (160) | |||||||||
Strain | WBStrain00001795 | ||||||||
WBStrain00001794 | |||||||||
WBStrain00022694 | |||||||||
WBStrain00031601 | |||||||||
WBStrain00055675 | |||||||||
WBStrain00055105 | |||||||||
WBStrain00055673 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (32) | |||||||||
Ortholog (46) | |||||||||
Structured_description | Concise_description | casy-1 encodes a type I transmembrane protein with two extracellular cadherin domains and an LG/LNS domain that is the sole C. elegans calsyntenin/alcadein ortholog; genetic studies indicate that in C. elegans casy-1 activity is required, in parallel to the insulin-like signaling pathway, for several types of learning, including salt chemotaxis learning, temperature learning, olfactory adaptation, and integration of two sensory stimuli; large-scale RNAi experiments also suggest that casy-1 plays a role in embryonic development; casy-1 expression in adult animals is able to rescue salt chemotaxis learning defects, indicating that CASY-1 function in mature animals is sufficient to effect proper chemotactic behavior; in addition, CASY-1 expression in the ASER neuron, but not other neurons, rescues salt chemotaxis learning defects, indicating the CASY-1 can act solely in this chemosensory neuron for normal salt chemotaxis learning; a casy-1::GFP promoter fusion is expressed throughout the nervous system, including the head amphid sensory neurons, with additional expression seen in the intestine and gonadal sheath cells; a CASY-1::GFP protein fusion localizes to the plasma membrane and intracellular membranes of neuronal cell bodies, with specific N-terminal fusions indicative of CASY-1 ectodomain release into the extracellular space; domain-specific rescue experiments indicate that the secreted, proteolytically processed CASY-1 extracellular domain is sufficient to rescue salt chemotaxis learning defects. | Paper_evidence | WBPaper00004508 | |||||
WBPaper00025054 | |||||||||
WBPaper00031647 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson324 | |||||||||
Date_last_updated | 03 Apr 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable several functions, including X11-like protein binding activity; amyloid-beta binding activity; and kinesin binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including extracellular region; neuromuscular junction; and neuronal cell body membrane. Expressed in neurons. Is an ortholog of human CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | B0034.3a | |||||||
B0034.3b | |||||||||
B0034.3c | |||||||||
B0034.3d | |||||||||
Corresponding_transcript | B0034.3a.1 | ||||||||
B0034.3b.1 | |||||||||
B0034.3c.1 | |||||||||
B0034.3d.1 | |||||||||
Other_sequence | NBC07241_1 | ||||||||
Dviv_isotig13549 | |||||||||
BXC03509_1 | |||||||||
CRC04578_1 | |||||||||
CR04244 | |||||||||
SSC00724_1 | |||||||||
Oden_isotig18047 | |||||||||
PT01582 | |||||||||
Dviv_isotig13550 | |||||||||
AW562078.1 | |||||||||
FG975776.1 | |||||||||
EX541379.1 | |||||||||
CJC01302_1 | |||||||||
JO471953.1 | |||||||||
Oden_isotig24364 | |||||||||
Dviv_isotig23395 | |||||||||
AE04077 | |||||||||
HBC02941_1 | |||||||||
Oden_isotig26034 | |||||||||
AYC02999_1 | |||||||||
AW308631.1 | |||||||||
FG971146.1 | |||||||||
AYC01371_1 | |||||||||
OFC00896_1 | |||||||||
ACC03263_1 | |||||||||
OVC01740_1 | |||||||||
FG979482.1 | |||||||||
FG981079.1 | |||||||||
FG980070.1 | |||||||||
FF681586.1 | |||||||||
FF680576.1 | |||||||||
JI473676.1 | |||||||||
Dviv_isotig13551 | |||||||||
EX545653.1 | |||||||||
AW308622.1 | |||||||||
JI165777.1 | |||||||||
ACC10431_1 | |||||||||
MI03879 | |||||||||
NBC06466_1 | |||||||||
JI479781.1 | |||||||||
Acan_isotig06704 | |||||||||
MIC00951_1 | |||||||||
BUC01549_1 | |||||||||
TX00688 | |||||||||
EX911437.1 | |||||||||
FF680648.1 | |||||||||
BE230814.1 | |||||||||
OF00898 | |||||||||
EX543624.1 | |||||||||
EX534812.1 | |||||||||
Hbac_isotig01436 | |||||||||
NB09487 | |||||||||
JO474406.1 | |||||||||
FG972013.1 | |||||||||
FG974792.1 | |||||||||
JI459718.1 | |||||||||
BG809000.1 | |||||||||
MI01414 | |||||||||
HBC01388_1 | |||||||||
ACC04500_1 | |||||||||
JO469238.1 | |||||||||
ASC04254_1 | |||||||||
AE02928 | |||||||||
FG971912.1 | |||||||||
PTC00577_1 | |||||||||
ACC17117_1 | |||||||||
FG972754.1 | |||||||||
Acan_isotig06703 | |||||||||
Oden_isotig29616 | |||||||||
CBC12338_1 | |||||||||
HBC27347_1 | |||||||||
JI480661.1 | |||||||||
AW208337.1 | |||||||||
NB11496 | |||||||||
FG979879.1 | |||||||||
FG973913.1 | |||||||||
TCC00067_1 | |||||||||
AS10295 | |||||||||
SS01262 | |||||||||
FG980307.1 | |||||||||
Associated_feature | WBsf665239 | ||||||||
WBsf665573 | |||||||||
WBsf665574 | |||||||||
WBsf665575 | |||||||||
WBsf665576 | |||||||||
WBsf665577 | |||||||||
WBsf665578 | |||||||||
WBsf665579 | |||||||||
WBsf665580 | |||||||||
WBsf665581 | |||||||||
WBsf988007 | |||||||||
WBsf988008 | |||||||||
WBsf988009 | |||||||||
WBsf988010 | |||||||||
WBsf988011 | |||||||||
WBsf988012 | |||||||||
WBsf988013 | |||||||||
WBsf988014 | |||||||||
WBsf988015 | |||||||||
WBsf1012286 | |||||||||
WBsf1012287 | |||||||||
WBsf1012288 | |||||||||
WBsf1012289 | |||||||||
WBsf1012290 | |||||||||
WBsf1012291 | |||||||||
WBsf1012292 | |||||||||
WBsf1012293 | |||||||||
WBsf223115 | |||||||||
WBsf223116 | |||||||||
Experimental_info | RNAi_result | WBRNAi00038664 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027950 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009558 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038665 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (17) | |||||||||
Drives_construct | WBCnstr00002178 | ||||||||
WBCnstr00004247 | |||||||||
WBCnstr00006267 | |||||||||
WBCnstr00006270 | |||||||||
WBCnstr00013090 | |||||||||
WBCnstr00013091 | |||||||||
WBCnstr00013376 | |||||||||
WBCnstr00023001 | |||||||||
WBCnstr00023062 | |||||||||
WBCnstr00037567 | |||||||||
Construct_product | WBCnstr00006267 | ||||||||
WBCnstr00013091 | |||||||||
WBCnstr00018580 | |||||||||
WBCnstr00018581 | |||||||||
WBCnstr00018582 | |||||||||
WBCnstr00018583 | |||||||||
WBCnstr00019712 | |||||||||
WBCnstr00037567 | |||||||||
Microarray_results (31) | |||||||||
Expression_cluster (237) | |||||||||
Interaction (44) | |||||||||
Map_info | Map | II | Position | -0.800583 | Error | 0.01344 | |||
Positive | Positive_clone | B0034 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 4194 | |||||||
4440 | |||||||||
Pseudo_map_position | |||||||||
Reference (27) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |