WormBase Tree Display for Gene: WBGene00006961
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WBGene00006961 | SMap | S_parent | Sequence | B0041 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | xnp | ||||||
Allele | WBVar00249710 | ||||||
WBVar01431446 | |||||||
WBVar01431447 | |||||||
WBVar01431448 | |||||||
WBVar00633541 | |||||||
WBVar01499919 | |||||||
WBVar00633542 | |||||||
WBVar00633543 | |||||||
WBVar00633544 | |||||||
WBVar00633545 | |||||||
WBVar00633546 | |||||||
WBVar00633547 | |||||||
WBVar00633548 | |||||||
WBVar00633549 | |||||||
WBVar00633550 | |||||||
WBVar00633551 | |||||||
WBVar00070824 | |||||||
WBVar00633552 | |||||||
WBVar00275610 | |||||||
WBVar00633553 | |||||||
WBVar00633554 | |||||||
WBVar01846459 | |||||||
WBVar00633555 | |||||||
WBVar00633556 | |||||||
WBVar00633557 | |||||||
WBVar00633558 | |||||||
WBVar00633559 | |||||||
WBVar00633560 | |||||||
WBVar01282463 | |||||||
WBVar01499786 | |||||||
WBVar00597744 | |||||||
WBVar01993187 | |||||||
WBVar01993188 | |||||||
WBVar01499985 | |||||||
WBVar01499818 | |||||||
WBVar01499819 | |||||||
WBVar00145332 | |||||||
WBVar00332940 | |||||||
WBVar00332941 | |||||||
WBVar00332942 | |||||||
WBVar00332943 | |||||||
WBVar00332944 | |||||||
WBVar00332945 | |||||||
WBVar00153271 | |||||||
WBVar00332946 | |||||||
WBVar01315250 | |||||||
WBVar00153272 | |||||||
WBVar00332947 | |||||||
WBVar00332948 | |||||||
WBVar00153273 | |||||||
WBVar00332949 | |||||||
WBVar00153274 | |||||||
WBVar00332950 | |||||||
WBVar00153275 | |||||||
WBVar00332951 | |||||||
WBVar00332952 | |||||||
WBVar00332953 | |||||||
WBVar02055590 | |||||||
WBVar00536824 | |||||||
WBVar01398973 | |||||||
WBVar01573974 | |||||||
WBVar02127209 | |||||||
WBVar02127210 | |||||||
WBVar01418423 | |||||||
WBVar02127211 | |||||||
WBVar01418434 | |||||||
WBVar01498959 | |||||||
WBVar00093021 | |||||||
Strain | WBStrain00002007 | ||||||
WBStrain00002321 | |||||||
WBStrain00037072 | |||||||
WBStrain00040593 | |||||||
WBStrain00021973 | |||||||
Component_of_genotype | WBGenotype00000009 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (38) | |||||||
Paralog (19) | |||||||
Structured_description | Concise_description | xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, and vulval morphogenesis; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells. | Paper_evidence | WBPaper00004103 | |||
WBPaper00024322 | |||||||
WBPaper00024692 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 27 Apr 2006 00:00:00 | ||||||
Automated_description | Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and catalytic activity, acting on a nucleic acid. Involved in several processes, including embryo development; gonad development; and vulval development. Predicted to be located in nucleus. Expressed in germ line; hermaphrodite gonad; and vulval precursor cell. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; and lung carcinoma (multiple). Is an ortholog of human ATRX (ATRX chromatin remodeler). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1059 | Homo sapiens | Paper_evidence | WBPaper00024322 | ||
WBPaper00024692 | |||||||
Accession_evidence | OMIM | 309580 | |||||
300448 | |||||||
301040 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 18 Apr 2013 00:00:00 | ||||||
Potential_model (12) | |||||||
Disease_relevance | Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. | Homo sapiens | Paper_evidence | WBPaper00024322 | |||
WBPaper00024692 | |||||||
WBPaper00003646 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 23 Apr 2013 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000158 | ||||||
WBDOannot00000309 | |||||||
WBDOannot00000614 | |||||||
WBDOannot00001020 | |||||||
Molecular_info | Corresponding_CDS | B0041.7 | |||||
Corresponding_CDS_history | B0041.7a:wp115 | ||||||
B0041.7b:wp115 | |||||||
Corresponding_transcript | B0041.7.1 | ||||||
Other_sequence (38) | |||||||
Associated_feature | WBsf649115 | ||||||
WBsf664165 | |||||||
WBsf983463 | |||||||
WBsf219305 | |||||||
WBsf219306 | |||||||
WBsf219307 | |||||||
WBsf219308 | |||||||
Experimental_info | RNAi_result | WBRNAi00038553 | Inferred_automatically | RNAi_primary | |||
WBRNAi00038550 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038555 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038549 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038551 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085664 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038691 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038552 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00075558 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038554 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00002790 | ||||||
WBCnstr00004416 | |||||||
WBCnstr00006334 | |||||||
WBCnstr00011208 | |||||||
WBCnstr00034068 | |||||||
Construct_product | WBCnstr00011208 | ||||||
WBCnstr00034068 | |||||||
Microarray_results (21) | |||||||
Expression_cluster (117) | |||||||
Interaction (20) | |||||||
Map_info | Map | I | Position | -1.02154 | Error | 0.001984 | |
Positive | Positive_clone | B0041 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4204 | |||||
5492 | |||||||
Pseudo_map_position | |||||||
Reference (19) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |