WormBase Tree Display for Gene: WBGene00004063

WBGene00004063 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: pmr-1
      Sequence_name: ZK256.1
      Molecular_name (11)
      Other_name: pmr1 Accession_evidence: EMBL AJ303081
              AJ303082
        CELE_ZK256.1 Accession_evidence: NDB BX284601
      Public_name: pmr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pmr
    Allele: WBVar00682678
      WBVar00250804
      WBVar00682679
      WBVar00682680
      WBVar00682681
      WBVar00682682
      WBVar00682683
      WBVar00682684
      WBVar00682685
      WBVar00263704
      WBVar00682686
      WBVar00682687
      WBVar00682688
      WBVar00682689
      WBVar01664950
      WBVar01664951
      WBVar00682690
      WBVar00682691
      WBVar01664952
      WBVar00068529
      WBVar01664953
      WBVar00682692
      WBVar01664954
      WBVar00682693
      WBVar00682694
      WBVar01664955
      WBVar01428933
      WBVar01664956
      WBVar00682695
      WBVar01428944
      WBVar01664957
      WBVar00682696
      WBVar01428955
      WBVar01664958
      WBVar00682697
      WBVar01428966
      WBVar00682698
      WBVar01664959
      WBVar01664960
      WBVar00682699
      WBVar01351111
      WBVar01428977
      WBVar00682700
      WBVar01428988
      WBVar01664961
      WBVar00682701
      WBVar01664962
      WBVar01664963
      WBVar00682702
      WBVar01664964
      WBVar00682703
      WBVar01351122
      WBVar00682704
      WBVar01664965
      WBVar01434126
      WBVar01664966
      WBVar00682705
      WBVar01434127
      WBVar01664967
      WBVar00682706
      WBVar01351133
      WBVar01434128
      WBVar00682707
      WBVar01434129
      WBVar01664968
      WBVar01434130
      WBVar00682708
      WBVar00682709
      WBVar01351144
      WBVar01434131
      WBVar00682710
      WBVar02052285
      WBVar01434133
      WBVar01495684
      WBVar01434134
      WBVar00682711
      WBVar01289218
      WBVar01434135
      WBVar00682712
      WBVar01289219
      WBVar01434136
      WBVar00682713
      WBVar00682714
      WBVar01434137
      WBVar00682715
      WBVar00682716
      WBVar02075488
      WBVar01499739
      WBVar00682717
      WBVar00682718
      WBVar00682719
      WBVar00682720
      WBVar00682721
      WBVar00682722
      WBVar01948059
      WBVar00160170
      WBVar00682723
      WBVar00682724
      WBVar01948060
      WBVar00160171
      WBVar00682725
      WBVar00160172
      WBVar01948061
      WBVar00276173
      WBVar01958503
      WBVar00682726
      WBVar00160173
      WBVar01948062
      WBVar00682727
      WBVar00160174
      WBVar01948063
      WBVar00160175
      WBVar00256755
      WBVar00682728
      WBVar00160176
      WBVar00160177
      WBVar00598076
      WBVar00160178
      WBVar02088815
      WBVar00349410
      WBVar02088816
      WBVar00160179
      WBVar00160180
      WBVar00349411
      WBVar00349412
      WBVar00160181
      WBVar00349413
      WBVar00160182
      WBVar00160183
      WBVar00349414
      WBVar00160184
      WBVar00349415
      WBVar00160185
      WBVar01556503
      WBVar00349416
      WBVar01556504
      WBVar00349417
      WBVar01556505
      WBVar00349418
      WBVar00349419
      WBVar01556506
      WBVar00349420
      WBVar01556507
      WBVar00349421
      WBVar01556508
      WBVar00349422
      WBVar01556509
      WBVar02056787
      WBVar00349423
      WBVar00349424
      WBVar00349425
      WBVar00349426
      WBVar00349427
      WBVar00349428
      WBVar00349429
      WBVar00349430
      WBVar00349431
      WBVar00349432
      WBVar00349433
      WBVar00349434
      WBVar00349435
      WBVar00349436
      WBVar01353622
      WBVar00349437
      WBVar01532463
      WBVar00349438
      WBVar00349439
      WBVar01353626
      WBVar01353627
      WBVar00349440
      WBVar00349441
      WBVar01353628
      WBVar01353630
      WBVar00349442
      WBVar01574442
      WBVar00349443
      WBVar01353631
      WBVar01574443
      WBVar00349444
      WBVar01574444
      WBVar01476420
      WBVar01914746
      WBVar01574445
      WBVar01914747
      WBVar01914748
      WBVar01914749
      WBVar02148606
      WBVar02148607
      WBVar00250715
      WBVar02052745
      WBVar02009931
      WBVar01499999
      WBVar02128830
      WBVar02128831
      WBVar02128832
      WBVar02128833
      WBVar02128834
      WBVar01500565
      WBVar00682624
      WBVar01500566
      WBVar00682625
      WBVar01500567
      WBVar01500568
      WBVar00682626
      WBVar00682627
      WBVar01500569
      WBVar00682628
      WBVar01500570
      WBVar01500571
      WBVar00682629
      WBVar00682630
      WBVar00682631
      WBVar00682632
      WBVar00682633
      WBVar00682634
      WBVar00682635
      WBVar00682636
      WBVar01826474
      WBVar01762432
      WBVar00682637
      WBVar00682638
      WBVar00682639
      WBVar00682640
      WBVar00682641
      WBVar00682642
      WBVar00682643
      WBVar00682644
      WBVar00682645
      WBVar00682646
      WBVar00682647
      WBVar00217785
      WBVar00682648
      WBVar00306211
      WBVar00682649
      WBVar00682650
      WBVar00300754
      WBVar00682651
      WBVar02011946
      WBVar00682652
      WBVar00682653
      WBVar00682654
      WBVar00682655
      WBVar00682656
      WBVar00682657
      WBVar00682658
      WBVar00682659
      WBVar00682660
      WBVar02028531
      WBVar00682661
      WBVar02002342
      WBVar02097394
      WBVar00682662
      WBVar02028532
      WBVar00682663
      WBVar02002343
      WBVar00301630
      WBVar00682664
      WBVar02002344
      WBVar00682665
      WBVar02002345
      WBVar00258165
      WBVar02002346
      WBVar00298063
      WBVar00682666
      WBVar02002347
      WBVar00298064
      WBVar00682667
      WBVar02087096
      WBVar02002348
      WBVar00298065
      WBVar00682668
      WBVar00682669
      WBVar02002349
      WBVar00682670
      WBVar02002350
      WBVar00682671
      WBVar00541675
      WBVar02002351
      WBVar00682672
      WBVar02002352
      WBVar00682673
      WBVar00682674
      WBVar00682675
      WBVar00682676
      WBVar00682677
    RNASeq_FPKM (74)
    GO_annotation (35)
    Contained_in_operon: CEOP1682
    Ortholog (42)
    Paralog (14)
    Structured_description: Concise_description: The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). Paper_evidence: WBPaper00004659
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables P-type calcium transporter activity and P-type manganese transporter activity. Involved in several processes, including metal ion transport; response to metal ion; and response to oxidative stress. Located in Golgi apparatus and membrane. Expressed in male gonad; seam cell; and spermatheca. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Is an ortholog of human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) and ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050429 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13211)
    Disease_relevance: C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpression of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. Homo sapiens Paper_evidence: WBPaper00041564
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 May 2013 00:00:00
  Molecular_info: Corresponding_CDS: ZK256.1a
      ZK256.1b
      ZK256.1c
    Corresponding_CDS_history: ZK256.1:wp114
      ZK256.1a:wp49
      ZK256.1b:wp77
    Corresponding_transcript (5)
    Other_sequence (75)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00059919 Inferred_automatically: RNAi_primary
      WBRNAi00038238 Inferred_automatically: RNAi_primary
      WBRNAi00116858 Inferred_automatically: RNAi_primary
      WBRNAi00059917 Inferred_automatically: RNAi_primary
      WBRNAi00059303 Inferred_automatically: RNAi_primary
      WBRNAi00059920 Inferred_automatically: RNAi_primary
      WBRNAi00086175 Inferred_automatically: RNAi_primary
      WBRNAi00059921 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1105
      Expr3187
      Expr7200
      Expr1017781
      Expr1031961
      Expr1162731
      Expr2014977
      Expr2033212
    Drives_construct: WBCnstr00003233
      WBCnstr00011207
    Construct_product: WBCnstr00011207
    Antibody: WBAntibody00000363
    Microarray_results (31)
    Expression_cluster (114)
    Interaction (69)
  Map_info: Map: I Position: 17.0977 Error: 0.064933
    Positive: Positive_clone: ZK256 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5071
    Pseudo_map_position
  Reference (22)
  Remark: Sequence connection from [Van Baelenk, Wuytack, F]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene