WormBase Tree Display for Gene: WBGene00002271
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WBGene00002271 | SMap | S_parent | Sequence | R07B1 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lec-8 | |||||||
Sequence_name | R07B1.10 | ||||||||
Molecular_name | R07B1.10 | ||||||||
R07B1.10.1 | |||||||||
CE26721 | |||||||||
Other_name | CELE_R07B1.10 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lec-8 | ||||||||
DB_info | Database | AceView | gene | XK469 | |||||
WormQTL | gene | WBGene00002271 | |||||||
WormFlux | gene | WBGene00002271 | |||||||
NDB | locus_tag | CELE_R07B1.10 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00002271|UniProtKB=Q09610 | |||||||
family | PTHR11346 | ||||||||
NCBI | gene | 181198 | |||||||
RefSeq | protein | NM_077248.6 | |||||||
SwissProt | UniProtAcc | Q09610 | |||||||
UniProt_GCRP | UniProtAcc | Q09610 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lec | ||||||||
Allele | WBVar02065786 | ||||||||
WBVar00250469 | |||||||||
WBVar01897802 | |||||||||
WBVar01897803 | |||||||||
WBVar01887997 | |||||||||
WBVar01887998 | |||||||||
WBVar02139908 | |||||||||
WBVar01493769 | |||||||||
WBVar01176998 | |||||||||
WBVar01176999 | |||||||||
WBVar01177000 | |||||||||
WBVar01177001 | |||||||||
WBVar01177003 | |||||||||
WBVar01498960 | |||||||||
WBVar01500067 | |||||||||
Legacy_information | [Arata Y] No mutants known. Encodes predicted galectin. Predicted gene R07B1.10 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00055082 | ||||||||
00055083 | |||||||||
00055084 | |||||||||
00055085 | |||||||||
00055086 | |||||||||
00055087 | |||||||||
00055088 | |||||||||
00105641 | |||||||||
00105732 | |||||||||
00110343 | |||||||||
Ortholog (51) | |||||||||
Paralog (26) | |||||||||
Structured_description | Concise_description | lec-8 encodes a glycolipid-binding galectin; LEC-8 binds glycolipids and can inhibit Bacillus thuringiensis Cry5B from binding glycolipids; lec-8 mutants are more susceptible to Cry5B; lec-8 is expressed in the pharyngeal-intestinal valve, the intestinal-rectal valve, and in some vesicles of the intestine; lec-8 expression in the intestine is induced in response to bacterial infection and Cry5B, suggesting that LEC-8 plays a role in host defense response. | Paper_evidence | WBPaper00005382 | |||||
WBPaper00034766 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 19 Jun 2013 00:00:00 | ||||||||
Automated_description | Enables glycolipid binding activity. Involved in response to toxic substance. Located in cytoplasmic vesicle. Expressed in intestine; pharyngeal-intestinal valve; tail; virL; and virR. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; aortic valve stenosis; and liver cirrhosis. Is an ortholog of human LGALS3 (galectin 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0080600 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||
DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||||
DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||||
DOID:1712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6563) | ||||||
Molecular_info | Corresponding_CDS | R07B1.10 | |||||||
Corresponding_CDS_history | R07B1.10:wp40 | ||||||||
Corresponding_transcript | R07B1.10.1 | ||||||||
Other_sequence (330) | |||||||||
Associated_feature | WBsf662381 | ||||||||
WBsf236202 | |||||||||
Experimental_info | RNAi_result | WBRNAi00090691 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00051410 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00034675 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00075968 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00002134 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00017500 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (7) | |||||||||
Drives_construct | WBCnstr00013423 | ||||||||
WBCnstr00036342 | |||||||||
Construct_product | WBCnstr00013423 | ||||||||
WBCnstr00036342 | |||||||||
Antibody | WBAntibody00002492 | ||||||||
Microarray_results (18) | |||||||||
Expression_cluster (299) | |||||||||
Interaction (180) | |||||||||
Map_info | Map | X | Position | 1.72773 | Error | 0.000844 | |||
Positive | Positive_clone | R07B1 | Person_evidence | WBPerson763 | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Pseudo_map_position | |||||||||
Reference (14) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |