dim-1 encodes novel proteins containing three immunoglobulin-like repeats in the carboxy terminus; dim-1 was originally identified in screens for mutations that suppress locomotion defects caused by aberrant muscle assembly in animals carrying a missense mutation in unc-112, which encodes a pleckstrin homology domain-containing protein required for the early stages of muscle assembly; loss-of-function mutations in dim-1 indicate that DIM-1 is required for fully normal muscle organization and proper anchoring of the myofilament lattice to the muscle cell membrane; a DIM-1(S)::GFP fusion protein made with the shorter of the DIM-1 isoforms localizes to an area adjacent to the muscle cell membrane, around and between the dense bodies; the DIM-1(S) isoform is sufficient for rescue of muscle structure and stability in dim-1 mutant hermaphrodites.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.