WormBase Tree Display for Gene: WBGene00000561
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WBGene00000561 | Evidence | Paper_evidence | WBPaper00004409 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C34E10 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | cnd-1 | Person_evidence | WBPerson105 | |||||
WBPerson293 | |||||||||
Sequence_name | C34E10.7 | ||||||||
Molecular_name | C34E10.7 | ||||||||
C34E10.7.1 | |||||||||
CE01187 | |||||||||
Other_name | hlh-5 | Person_evidence | WBPerson346 | ||||||
C34E10.d | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
C34E10 | Paper_evidence | WBPaper00027608 | |||||||
CeND | Paper_evidence | WBPaper00027608 | |||||||
CELE_C34E10.7 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | cnd-1 | ||||||||
DB_info | Database | AceView | gene | 3G328 | |||||
WormQTL | gene | WBGene00000561 | |||||||
WormFlux | gene | WBGene00000561 | |||||||
OMIM | disease | 125853 | |||||||
606394 | |||||||||
gene | 601724 | ||||||||
601725 | |||||||||
NDB | locus_tag | CELE_C34E10.7 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000561|UniProtKB=P46581 | |||||||
family | PTHR19290 | ||||||||
NCBI | gene | 183212 | |||||||
RefSeq | protein | NM_001392092.1 | |||||||
SwissProt | UniProtAcc | P46581 | |||||||
UniProt_GCRP | UniProtAcc | P46581 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cnd | ||||||||
Allele | WBVar02125339 | Inferred_automatically | From strain object: OH10733 | ||||||
WBVar02125340 | Inferred_automatically | From strain object: OH10739 | |||||||
WBVar00090770 | |||||||||
WBVar00397564 | |||||||||
WBVar00397565 | |||||||||
WBVar00397566 | |||||||||
WBVar00397567 | |||||||||
WBVar00146041 | |||||||||
WBVar00258208 | |||||||||
WBVar00088143 | |||||||||
WBVar01995192 | |||||||||
WBVar00060031 | |||||||||
WBVar02010485 | |||||||||
WBVar00146092 | |||||||||
WBVar01835528 | |||||||||
WBVar01644617 | |||||||||
WBVar01644618 | |||||||||
WBVar01644619 | |||||||||
WBVar01893347 | |||||||||
WBVar00826469 | |||||||||
WBVar00826470 | |||||||||
WBVar00826471 | |||||||||
WBVar00826472 | |||||||||
WBVar00826473 | |||||||||
WBVar00265096 | |||||||||
WBVar00826474 | |||||||||
WBVar00826475 | |||||||||
WBVar00826476 | |||||||||
WBVar00826477 | |||||||||
WBVar00826478 | |||||||||
WBVar00826479 | |||||||||
WBVar00826480 | |||||||||
WBVar00826481 | |||||||||
WBVar00826482 | |||||||||
WBVar00826483 | |||||||||
WBVar00826484 | |||||||||
WBVar00826485 | |||||||||
WBVar00826486 | |||||||||
WBVar00826487 | |||||||||
WBVar00826488 | |||||||||
WBVar00826489 | |||||||||
WBVar00826490 | |||||||||
WBVar00826491 | |||||||||
WBVar00826492 | |||||||||
WBVar01962714 | |||||||||
WBVar01263510 | |||||||||
WBVar01263511 | |||||||||
WBVar01263513 | |||||||||
WBVar00259809 | |||||||||
WBVar01495827 | |||||||||
WBVar00397556 | |||||||||
WBVar00397557 | |||||||||
WBVar00397558 | |||||||||
WBVar00397559 | |||||||||
WBVar00397560 | |||||||||
WBVar00397561 | |||||||||
WBVar00397562 | |||||||||
WBVar00397563 | |||||||||
Strain (6) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (17) | |||||||||
Ortholog (57) | |||||||||
Paralog | WBGene00001957 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
WBGene00003595 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
WormBase-Compara | |||||||||
WBGene00001953 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
WBGene00001960 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00001961 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00003018 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00009540 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00013665 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | cnd-1 encodes a basic helix-loop-helix protein that is most closely related to the vertebrate NeuroD transcription factors; during development, CND-1 is predicted to function as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding; CND-1::GFP expression begins in early embryogenesis (<20 cells) in four AB descendants and then continues in mitotically active AB-derived neuronal precursors, unidentified nuclei during gastrulation and enclosure, and postmitotic neurons in the head and ventral cord; at hatching CND-1::GFP expression is visible in ventral cord neurons, but this expression disappears completely by the end of the first larval stage; CND-1::GFP does not appear to be expressed in any non-neuronal ectodermal cells, as its expression does not overlap with that of LIN-26. | Paper_evidence | WBPaper00004409 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 11 May 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in axonal fasciculation and negative regulation of gliogenesis. Located in nucleus. Expressed in several structures, including ABalpapaa; ABalppapa; motor neurons; neuroblasts; and somatic nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72; glucose metabolism disease (multiple); and obesity. Is an ortholog of several human genes including NEUROD1 (neuronal differentiation 1); NEUROD2 (neuronal differentiation 2); and NEUROD4 (neuronal differentiation 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||
DOID:4195 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
DOID:10603 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
DOID:0111104 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
DOID:0112208 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7763) | ||||||
Disease_relevance | In humans, mutations in Neurogenic Differentiation 1 (NeuroD1) have been implicated in Diabetes Mellitus, Type II and Maturity-onset diabetes of the young, type VI; in elegans, cnd-1, seems to have combined the function of several vertebrate neurogenic bHLH proteins, and is required for the proper fate specification and terminal differentiation of motor neurons. | Homo sapiens | Paper_evidence | WBPaper00004409 | |||||
Accession_evidence | OMIM | 606394 | |||||||
125853 | |||||||||
601724 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 06 Sep 2013 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C34E10.7 | |||||||
Corresponding_transcript | C34E10.7.1 | ||||||||
Other_sequence | Dviv_isotig35392 | ||||||||
Dviv_isotig31167 | |||||||||
JI178639.1 | |||||||||
Tcol_isotig15910 | |||||||||
Associated_feature | WBsf651039 | ||||||||
WBsf666900 | |||||||||
WBsf978355 | |||||||||
WBsf992340 | |||||||||
WBsf992341 | |||||||||
WBsf226653 | |||||||||
Transcription_factor | WBTranscriptionFactor000076 | ||||||||
WBTranscriptionFactor000060 | |||||||||
Experimental_info | RNAi_result | WBRNAi00107382 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041895 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00029528 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00005521 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066068 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00011606 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (18) | |||||||||
Drives_construct | WBCnstr00004609 | ||||||||
WBCnstr00004610 | |||||||||
WBCnstr00004611 | |||||||||
WBCnstr00013822 | |||||||||
WBCnstr00015211 | |||||||||
WBCnstr00015212 | |||||||||
WBCnstr00015213 | |||||||||
WBCnstr00037451 | |||||||||
WBCnstr00042892 | |||||||||
WBCnstr00042894 | |||||||||
Construct_product | WBCnstr00013822 | ||||||||
WBCnstr00015371 | |||||||||
WBCnstr00015372 | |||||||||
WBCnstr00016754 | |||||||||
WBCnstr00016967 | |||||||||
WBCnstr00021504 | |||||||||
WBCnstr00037451 | |||||||||
Regulate_expr_cluster | WBPaper00059932:cnd-1(ju29)_downregulated | ||||||||
WBPaper00059932:cnd-1(ju29)_upregulated | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (159) | |||||||||
Interaction (102) | |||||||||
Map_info | Map | III | Position | -1.85688 | Error | 0.001135 | |||
Positive | Positive_clone | C34E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
ZC129 | |||||||||
Mapping_data | 2_point | 7160 | |||||||
Multi_point | 4094 | ||||||||
Pos_neg_data | 10730 | ||||||||
Reference (38) | |||||||||
Remark | Postitive method is cosmid rescue | Paper_evidence | WBPaper00004409 | ||||||
Method | Gene |