WormBase Tree Display for Gene: WBGene00000298
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WBGene00000298 | SMap | S_parent | Sequence | CHROMOSOME_V | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cat | ||||||
Reference_allele | WBVar00143773 | ||||||
Allele | WBVar02144113 | Inferred_automatically | From strain object: LC141 | ||||
WBVar02144114 | |||||||
WBVar01461524 | |||||||
WBVar01461525 | |||||||
WBVar02060792 | |||||||
WBVar01500097 | |||||||
WBVar00091640 | |||||||
WBVar00143773 | |||||||
WBVar01500129 | |||||||
WBVar01043528 | |||||||
WBVar01043529 | |||||||
WBVar01043530 | |||||||
WBVar01043531 | |||||||
WBVar01043532 | |||||||
WBVar01043533 | |||||||
WBVar01043534 | |||||||
WBVar01043535 | |||||||
WBVar01043536 | |||||||
WBVar00249801 | |||||||
WBVar01499450 | |||||||
WBVar01499451 | |||||||
WBVar01500208 | |||||||
WBVar01500209 | |||||||
WBVar00468926 | |||||||
WBVar00468927 | |||||||
WBVar00468928 | |||||||
WBVar00468929 | |||||||
WBVar01499316 | |||||||
Legacy_information | e1141 : dopamine reduced > 90%. ES1 ME2 NA1. | ||||||
[Leon Avery] Serotonin is reduced or absent (CGC#1105). | |||||||
See also e1141 | |||||||
[C.elegansII] e1141 : dopamine reduced > 90%, serotonin reduced orabsent; poor male turning behavior; enhanced foraging behavior, suppressed by serotonin agonists; serotonin immunoreactivity restored by exogenous serotonin or 5-hydroxytryptophan;cuticle defective, hypersensitive to SDS, levamisole,hypochlorite.. ES1 ME2 NA1. [Sulston et al. 1975; Loer and Kenyon 1993; DA; KP; LC] | |||||||
Strain | WBStrain00024111 | ||||||
WBStrain00024121 | |||||||
WBStrain00027351 | |||||||
WBStrain00004253 | |||||||
WBStrain00004816 | |||||||
WBStrain00024116 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (27) | |||||||
Ortholog (39) | |||||||
Structured_description | Automated_description | Enables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; dopaminergic neurons; hyp7 syncytium; intestinal cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; and movement disease (multiple). Is an ortholog of human GCH1 (GTP cyclohydrolase 1). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (11) | ||||||
Molecular_info | Corresponding_CDS | F32G8.6 | |||||
Corresponding_transcript | F32G8.6.1 | ||||||
Other_sequence (413) | |||||||
Associated_feature | WBsf047518 | ||||||
WBsf047519 | |||||||
WBsf047520 | |||||||
WBsf1001139 | |||||||
WBsf1020318 | |||||||
WBsf232395 | |||||||
Experimental_info | RNAi_result | WBRNAi00031695 | Inferred_automatically | RNAi_primary | |||
WBRNAi00115602 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00014232 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00115714 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00046157 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00115603 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00115701 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr4817 | ||||||
Expr12165 | |||||||
Expr1027591 | |||||||
Expr1150045 | |||||||
Expr2009728 | |||||||
Expr2027967 | |||||||
Drives_construct | WBCnstr00012257 | ||||||
WBCnstr00015879 | |||||||
WBCnstr00017075 | |||||||
WBCnstr00020335 | |||||||
WBCnstr00037596 | |||||||
Construct_product | WBCnstr00012257 | ||||||
WBCnstr00037596 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (261) | |||||||
Interaction (175) | |||||||
Map_info | Map | V | Position | 2.59941 | Error | 0.001738 | |
Positive | Positive_clone | F32G8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 151 | |||||
1529 | |||||||
2269 | |||||||
Pos_neg_data | 6765 | ||||||
6766 | |||||||
6767 | |||||||
6769 | |||||||
6771 | |||||||
Reference (94) | |||||||
Remark | Interacting_genes '[Leon Avery] unc-31: cat-4 enhances the Egl defect of unc-31 mutants, especially at 15C. | ||||||
Method | Gene |