WormBase Tree Display for Gene: WBGene00000233

WBGene00000233 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 1
    Name: CGC_name: avr-15 Person_evidence: WBPerson1122
      Sequence_name: R11G10.1
      Molecular_name: R11G10.1a
        R11G10.1a.1
        CE25076
        R11G10.1b
        CE13573
        R11G10.1c
        CE45109
        R11G10.1b.1
        R11G10.1c.1
      Other_name: CELE_R11G10.1 Accession_evidence: NDB BX284605
      Public_name: avr-15
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: avr
    Allele: WBVar00091372
      WBVar00475028
      WBVar01061683
      WBVar00475029
      WBVar01061684
      WBVar00475030
      WBVar01061685
      WBVar01061686
      WBVar00475031
      WBVar01061687
      WBVar00475032
      WBVar00475033
      WBVar01061688
      WBVar01061689
      WBVar01061690
      WBVar01061691
      WBVar01061692
      WBVar02024489
      WBVar01061693
      WBVar01061694
      WBVar01061695
      WBVar01061696
      WBVar01061697
      WBVar01061698
      WBVar02141364
      WBVar01061699
      WBVar01061700
      WBVar01061701
      WBVar01061702
      WBVar01809034
      WBVar01061703
      WBVar01061704
      WBVar01809035
      WBVar01061705
      WBVar01809036
      WBVar01061706
      WBVar01809037
      WBVar01061707
      WBVar01061708
      WBVar01061709
      WBVar00000083
      WBVar01061710
      WBVar01061711
      WBVar01061712
      WBVar01061713
      WBVar01061714
      WBVar01061715
      WBVar01061716
      WBVar01061717
      WBVar01061718
      WBVar01061719
      WBVar01061720
      WBVar01743992
      WBVar01743993
      WBVar01061721
      WBVar01743994
      WBVar01061722
      WBVar01743995
      WBVar01061723
      WBVar01743996
      WBVar01061724
      WBVar01061725
      WBVar01743997
      WBVar01061726
      WBVar01061727
      WBVar01061728
      WBVar01061729
      WBVar01061730
      WBVar01061731
      WBVar01061732
      WBVar01061733
      WBVar01703187
      WBVar01061734
      WBVar01061735
      WBVar01061736
      WBVar01631088
      WBVar01061737
      WBVar01061738
      WBVar00256945
      WBVar00304613
      WBVar01061739
      WBVar01061740
      WBVar01061741
      WBVar00256947
      WBVar01061742
      WBVar00256948
      WBVar01061743
      WBVar01061744
      WBVar00256951
      WBVar01061745
      WBVar01061746
      WBVar01061747
      WBVar01061748
      WBVar02148292
      WBVar01061749
      WBVar01061750
      WBVar01842429
      WBVar01061751
      WBVar01842430
      WBVar01061752
      WBVar01842431
      WBVar01061753
      WBVar01061754
      WBVar01842432
      WBVar01061755
      WBVar01842433
      WBVar01061756
      WBVar01842434
      WBVar01061757
      WBVar01842435
      WBVar01842436
      WBVar01061758
      WBVar01061759
      WBVar01842437
      WBVar01061760
      WBVar01061761
      WBVar01869716
      WBVar01061762
      WBVar01061763
      WBVar01869717
      WBVar00264881
      WBVar01869718
      WBVar01061764
      WBVar02054765
      WBVar00590514
      WBVar01061765
      WBVar01869719
      WBVar01869720
      WBVar01484878
      WBVar00590516
      WBVar01061766
      WBVar01061767
      WBVar01869721
      WBVar01061768
      WBVar01869722
      WBVar01869723
      WBVar01061769
      WBVar01869724
      WBVar01061770
      WBVar01869725
      WBVar01061771
      WBVar01061772
      WBVar01869726
      WBVar01061773
      WBVar01869727
      WBVar01869728
      WBVar01061774
      WBVar01869729
      WBVar01061775
      WBVar01869730
      WBVar01061776
      WBVar01869731
      WBVar01869732
      WBVar01869733
      WBVar01869734
      WBVar01869735
      WBVar01869736
      WBVar01869737
      WBVar01869738
      WBVar01869739
      WBVar01869740
      WBVar00012735
      WBVar01869741
      WBVar01499621
      WBVar01869742
      WBVar01869743
      WBVar00012740
      WBVar01869744
      WBVar01869745
      WBVar01869746
      WBVar00012745
      WBVar00315834
      WBVar01869747
      WBVar01869748
      WBVar01869749
      WBVar01869750
      WBVar00012750
      WBVar01869751
      WBVar01869752
      WBVar01869753
      WBVar00012755
      WBVar01869754
      WBVar01462522
      WBVar01869755
      WBVar00012760
      WBVar01462523
      WBVar01869756
      WBVar01462524
      WBVar01869757
      WBVar00012765
      WBVar01462525
      WBVar01869758
      WBVar01869759
      WBVar01462526
      WBVar01462527
      WBVar01869760
      WBVar00012770
      WBVar01869761
      WBVar01462528
      WBVar01869762
      WBVar01462529
      WBVar01869763
      WBVar01869764
      WBVar01869765
      WBVar01869766
      WBVar01869767
      WBVar01869768
      WBVar01869769
      WBVar01869770
      WBVar02090919
      WBVar01869771
      WBVar01869772
      WBVar01869773
      WBVar01869774
      WBVar01869775
      WBVar01869776
      WBVar01848396
      WBVar01869777
      WBVar01869778
      WBVar01869779
      WBVar01869780
      WBVar01500212
      WBVar01869781
      WBVar01500213
      WBVar01869782
      WBVar01869783
      WBVar01869784
      WBVar01869785
      WBVar02061851
      WBVar01869786
      WBVar02061852
      WBVar02061853
      WBVar01869787
      WBVar01499299
      WBVar01869788
      WBVar02061854
      WBVar02061855
      WBVar01869789
      WBVar00256118
      WBVar02061856
      WBVar01869790
      WBVar01869791
      WBVar02061857
      WBVar01869792
      WBVar02061858
      WBVar01869793
      WBVar02061859
      WBVar01869794
      WBVar02061860
      WBVar02061861
      WBVar01869795
      WBVar02061862
      WBVar01869796
      WBVar02061863
      WBVar01869797
      WBVar02061864
      WBVar01869798
      WBVar01869799
      WBVar02061865
      WBVar01869800
      WBVar02115609
      WBVar02061866
      WBVar00475008
      WBVar01869801
      WBVar02115610
      WBVar02115611
      WBVar01869802
      WBVar00475009
      WBVar01869803
      WBVar00475010
      WBVar01492505
      WBVar02115612
      WBVar00475011
      WBVar01869804
      WBVar02115613
      WBVar01499316
      WBVar00475012
      WBVar01869805
      WBVar01869806
      WBVar00475013
      WBVar01869807
      WBVar00475014
      WBVar01869808
      WBVar00475015
      WBVar00475016
      WBVar01869809
      WBVar01869810
      WBVar00475017
      WBVar00475018
      WBVar01869811
      WBVar00475019
      WBVar01869812
      WBVar01061675
      WBVar00475020
      WBVar01869813
      WBVar01061676
      WBVar00475021
      WBVar00475022
      WBVar01061677
      WBVar01061678
      WBVar00475023
      WBVar01061679
      WBVar00475024
      WBVar01061680
      WBVar00475025
      WBVar00475026
      WBVar01061681
      WBVar01590386
      WBVar00475027
      WBVar01061682
    Legacy_information: [Dent JA] >20x synthetic avermectin resistance. Lacks M3 neurotransmission. Slightly starved. Prolonged pharyngeal contractions. Encodes ivermectin-sensitive glutamate-gated chloride channel subunit (?predicted gene T10G3.6).
      ad1051 : Eat phenotype, lacks M3-derived IPSP; isolated pharynx insensitive to iontophoretically applied glutamate.[CD; AD]
    Strain (15)
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog (56)
    Paralog (100)
    Structured_description: Concise_description: avr-15 encodes, via alternative splicing, two glutamate-gated chloride channel subunit homologs; these proteins mediate fast inhibitory glutamatergic neuromuscular transmission, as well as ivermectin sensitivity, and are required for normal pharyngeal function. Paper_evidence: WBPaper00002920
            WBPaper00003954
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in action potential; locomotion involved in locomotory behavior; and regulation of pharyngeal pumping. Predicted to be located in neuron projection and synapse. Expressed in motor neurons; pharynx; preanal ganglion neurons; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in hyperekplexia 2 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2); GLRA3 (glycine receptor alpha 3); and GLRB (glycine receptor beta). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070422 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4327)
      DOID:0060697 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4329)
  Molecular_info: Corresponding_CDS: R11G10.1a
      R11G10.1b
      R11G10.1c
    Corresponding_CDS_history: R11G10.1:wp51
    Corresponding_transcript: R11G10.1a.1
      R11G10.1b.1
      R11G10.1c.1
    Other_sequence (39)
    Associated_feature: WBsf653315
      WBsf653316
      WBsf653317
      WBsf653318
      WBsf1001831
      WBsf1001832
      WBsf1020728
      WBsf234818
      WBsf234819
      WBsf234820
  Experimental_info: RNAi_result: WBRNAi00018559 Inferred_automatically: RNAi_primary
      WBRNAi00030215 Inferred_automatically: RNAi_primary
      WBRNAi00085183 Inferred_automatically: RNAi_primary
      WBRNAi00017762 Inferred_automatically: RNAi_primary
      WBRNAi00051804 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1454
      Expr1799
      Expr13471
      Expr13480
      Expr1011432
      Expr1155465
      Expr2009524
      Expr2027761
    Drives_construct: WBCnstr00004936
      WBCnstr00010282
      WBCnstr00010455
      WBCnstr00015856
    Construct_product (13)
    Microarray_results (31)
    Expression_cluster (163)
    Interaction (14)
  Map_info: Map: V Position: 5.39241 Error: 0.010538
    Well_ordered
    Positive: Positive_clone: K10B8
        R11G10 Inferred_automatically: From sequence, transcript, pseudogene data
        T10G3
    Negative: Outside_rearr: yDf8
    Mapping_data: Multi_point: 4176
      Pos_neg_data: 9130
  Reference (65)
  Remark: T10G3.7 sequence removed, now named R11G10.1 in sequence annotation. [sdm 05/00]
  Method: Gene