WormBase Tree Display for Gene: WBGene00003997
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| WBGene00003997 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-3 | Person_evidence | WBPerson490 | |||||
| Sequence_name | ZK455.7 | ||||||||
| Molecular_name | ZK455.7 | ||||||||
| ZK455.7.1 | |||||||||
| CE03818 | |||||||||
| Other_name | cepgpC | Accession_evidence | EMBL | X65055 | |||||
| CELE_ZK455.7 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | pgp-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele | WBVar00239172 | ||||||||
| WBVar01187330 | |||||||||
| WBVar01187331 | |||||||||
| WBVar01187332 | |||||||||
| WBVar01499887 | |||||||||
| WBVar01187333 | |||||||||
| WBVar01187334 | |||||||||
| WBVar01499888 | |||||||||
| WBVar01499710 | |||||||||
| WBVar00094258 | |||||||||
| WBVar02145050 | |||||||||
| WBVar00239160 | |||||||||
| WBVar00301483 | |||||||||
| WBVar02009122 | |||||||||
| WBVar02009123 | |||||||||
| WBVar00083128 | |||||||||
| WBVar01690456 | |||||||||
| WBVar01690457 | |||||||||
| WBVar01690458 | |||||||||
| WBVar01690459 | |||||||||
| WBVar00517241 | |||||||||
| WBVar00517242 | |||||||||
| WBVar00517243 | |||||||||
| WBVar00517244 | |||||||||
| WBVar00517245 | |||||||||
| WBVar00517246 | |||||||||
| WBVar00517247 | |||||||||
| WBVar00517248 | |||||||||
| WBVar00517249 | |||||||||
| WBVar00517250 | |||||||||
| WBVar00517251 | |||||||||
| WBVar00517252 | |||||||||
| WBVar00517253 | |||||||||
| WBVar00517254 | |||||||||
| WBVar00517255 | |||||||||
| WBVar01620568 | |||||||||
| WBVar01471129 | |||||||||
| WBVar01759457 | |||||||||
| WBVar01471131 | |||||||||
| WBVar02151545 | |||||||||
| WBVar00094170 | |||||||||
| WBVar01498919 | |||||||||
| WBVar01498920 | |||||||||
| WBVar00068200 | |||||||||
| WBVar00068205 | |||||||||
| WBVar00068210 | |||||||||
| WBVar01187303 | |||||||||
| WBVar01187304 | |||||||||
| WBVar01187305 | |||||||||
| WBVar01187306 | |||||||||
| WBVar01187307 | |||||||||
| WBVar01187308 | |||||||||
| WBVar01187309 | |||||||||
| WBVar01187310 | |||||||||
| WBVar01187311 | |||||||||
| WBVar01187312 | |||||||||
| WBVar01187313 | |||||||||
| WBVar01187314 | |||||||||
| WBVar01187315 | |||||||||
| WBVar01187316 | |||||||||
| WBVar01187317 | |||||||||
| WBVar01187318 | |||||||||
| WBVar01187319 | |||||||||
| WBVar01187320 | |||||||||
| WBVar01187321 | |||||||||
| WBVar01187322 | |||||||||
| WBVar01187323 | |||||||||
| WBVar01187324 | |||||||||
| WBVar01602185 | |||||||||
| WBVar01187325 | |||||||||
| WBVar01602186 | |||||||||
| WBVar01498960 | |||||||||
| WBVar01187326 | |||||||||
| WBVar01187327 | |||||||||
| WBVar01187328 | |||||||||
| WBVar01500067 | |||||||||
| WBVar01187329 | |||||||||
| Legacy_information | [C.elegansII] pk18 : deletion derived from pk30tci, increased sensitivity to colchicine and to chloroquine; gross phenotype WT. Cloned: encodes 1254 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins. Transcripts present throughout development; pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-3 detected in apical membranes of gut and of excretory cell. [Broeks et al. 1995; NL] | ||||||||
| Strain | WBStrain00028887 | ||||||||
| WBStrain00028888 | |||||||||
| WBStrain00028891 | |||||||||
| WBStrain00033025 | |||||||||
| WBStrain00037266 | |||||||||
| WBStrain00004731 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (71) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells. | Paper_evidence | WBPaper00002180 | |||||
| WBPaper00003366 | |||||||||
| WBPaper00003925 | |||||||||
| WBPaper00004651 | |||||||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Apr 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to Gram-negative bacterium; innate immune response; and stress response to cadmium ion. Located in apical plasma membrane. Expressed in excretory canal; excretory cell; intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info | Corresponding_CDS | ZK455.7 | |||||||
| Corresponding_transcript | ZK455.7.1 | ||||||||
| Other_sequence | AJ577782.1 | ||||||||
| Acan_isotig15536 | |||||||||
| GR978971.1 | |||||||||
| Oden_isotig20479 | |||||||||
| ES880390.1 | |||||||||
| PPC07546_1 | |||||||||
| JI213191.1 | |||||||||
| HM635768.1 | |||||||||
| MH02620 | |||||||||
| ACC26020_1 | |||||||||
| Tcir_isotig04372 | |||||||||
| Tcol_isotig26711 | |||||||||
| EY471681.1 | |||||||||
| EX562340.1 | |||||||||
| HM635772.1 | |||||||||
| AJ577799.1 | |||||||||
| ES410195.1 | |||||||||
| SC00408 | |||||||||
| HBC06719_1 | |||||||||
| Name_isotig04888 | |||||||||
| HM635766.1 | |||||||||
| Associated_feature | WBsf1006975 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00059437 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022018 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014821 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001488 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00002142 | ||||||||
| WBCnstr00010331 | |||||||||
| WBCnstr00011338 | |||||||||
| WBCnstr00011339 | |||||||||
| WBCnstr00012125 | |||||||||
| WBCnstr00012126 | |||||||||
| WBCnstr00012634 | |||||||||
| WBCnstr00015310 | |||||||||
| WBCnstr00035753 | |||||||||
| Construct_product | WBCnstr00012634 | ||||||||
| WBCnstr00014565 | |||||||||
| WBCnstr00014566 | |||||||||
| WBCnstr00035753 | |||||||||
| Antibody | WBAntibody00000095 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (180) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | X | Position | 3.16596 | Error | 0.03869 | |||
| Positive | Positive_clone | PB#CPG4 | |||||||
| ZK455 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Pseudo_map_position | |||||||||
| Reference (46) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
