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WormBase Tree Display for Gene: WBGene00002271

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Name Class

WBGene00002271SMapS_parentSequenceR07B1
IdentityVersion1
NameCGC_namelec-8
Sequence_nameR07B1.10
Molecular_nameR07B1.10
R07B1.10.1
CE26721
Other_nameCELE_R07B1.10Accession_evidenceNDBBX284606
Public_namelec-8
DB_infoDatabaseAceViewgeneXK469
WormQTLgeneWBGene00002271
WormFluxgeneWBGene00002271
NDBlocus_tagCELE_R07B1.10
PanthergeneCAEEL|WormBase=WBGene00002271|UniProtKB=Q09610
familyPTHR11346
NCBIgene181198
RefSeqproteinNM_077248.6
SwissProtUniProtAccQ09610
UniProt_GCRPUniProtAccQ09610
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlec
AlleleWBVar02065786
WBVar00250469
WBVar01897802
WBVar01897803
WBVar01887997
WBVar01887998
WBVar02139908
WBVar01493769
WBVar01176998
WBVar01176999
WBVar01177000
WBVar01177001
WBVar01177003
WBVar01498960
WBVar01500067
Legacy_information[Arata Y] No mutants known. Encodes predicted galectin. Predicted gene R07B1.10
RNASeq_FPKM (74)
GO_annotation00055082
00055083
00055084
00055085
00055086
00055087
00055088
00105641
00105732
00110343
Ortholog (51)
Paralog (26)
Structured_descriptionConcise_descriptionlec-8 encodes a glycolipid-binding galectin; LEC-8 binds glycolipids and can inhibit Bacillus thuringiensis Cry5B from binding glycolipids; lec-8 mutants are more susceptible to Cry5B; lec-8 is expressed in the pharyngeal-intestinal valve, the intestinal-rectal valve, and in some vesicles of the intestine; lec-8 expression in the intestine is induced in response to bacterial infection and Cry5B, suggesting that LEC-8 plays a role in host defense response.Paper_evidenceWBPaper00005382
WBPaper00034766
Curator_confirmedWBPerson1843
Date_last_updated19 Jun 2013 00:00:00
Automated_descriptionEnables glycolipid binding activity. Involved in response to toxic substance. Located in cytoplasmic vesicle. Expressed in intestine; pharyngeal-intestinal valve; tail; virL; and virR. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; aortic valve stenosis; and liver cirrhosis. Is an ortholog of human LGALS3 (galectin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080600Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6563)
DOID:2841Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6563)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6563)
DOID:1712Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6563)
Molecular_infoCorresponding_CDSR07B1.10
Corresponding_CDS_historyR07B1.10:wp40
Corresponding_transcriptR07B1.10.1
Other_sequenceAB038499
ES413371.1
FD515384.1
FG974761.1
FG971651.1
FG979372.1
FG977424.1
FG981008.1
HBC07855_1
FK800781.1
FG974247.1
EX012552.1
FG975012.1
FG971432.1
EX914177.1
FG980554.1
EX916319.1
HBC01115_1
ES742617.1
FG976347.1
FG975411.1
EX915830.1
HBC00042_3
FG973809.1
HBC21791_1
ES743851.1
FG971131.1
ES743422.1
ES743394.1
TDC01536_1
EX011611.1
FF680261.1
ES742348.1
EX011177.1
FF681112.1
FK805525.1
EX012654.1
EX011199.1
EX009448.1
Tcol_isotig00905
FG974026.1
ES741103.1
EV850874.1
FG974950.1
FG972397.1
FF682027.1
EX915582.1
EX007955.1
GW411134.1
FK809709.1
FG978042.1
EX910787.1
EX009839.1
FG978982.1
FG973031.1
ES741178.1
FF679311.1
FF680978.1
DVC03018_1
FF679046.1
FG979011.1
ES411949.1
EX014991.1
FG973547.1
Dviv_isotig05644
FF681790.1
EX013293.1
FG975324.1
EX913616.1
HBC13470_1
FG975957.1
FG976458.1
ES409240.1
FG980215.1
HBC17466_1
ES740574.1
FG971174.1
FG975369.1
EX008432.1
FF678929.1
EX012868.1
Oden_isotig23789
EX910987.1
FG979898.1
DQ384534.1
EX013133.1
FG974935.1
ES740397.1
Tcol_isotig00907
FG971858.1
CB036879.1
EX007257.1
FF681544.1
FG972133.1
EX912600.1
EX009984.1
EX009718.1
Name_isotig04709
FG975830.1
EX012821.1
EX912397.1
FG979409.1
ES413486.1
ES410055.1
EX014546.1
ES408964.1
TDC00605_1
FF679644.1
FG976378.1
EX913309.1
FK802073.1
FG974807.1
FF682054.1
EX914493.1
Dviv_isotig05647
FK800823.1
EX911842.1
EX911856.1
EX910672.1
EX009497.1
FG980921.1
FG979290.1
FG975897.1
FG975146.1
ES408904.1
FG977255.1
FG979692.1
EX916657.1
ES413124.1
FG979331.1
CB038555.1
FG977493.1
EX914259.1
ES743213.1
FG976324.1
EX013789.1
FG972579.1
FD515218.1
ES410132.1
FG977137.1
FG975358.1
FG976688.1
FG979708.1
FG970969.1
FD516617.1
ES739263.1
EX913540.1
EX912044.1
FG980353.1
EX008473.1
FG980967.1
EV853830.1
GW406029.1
Tcir_isotig13076
FG979645.1
FD514407.1
FF681109.1
EX011804.1
EX910027.1
EX012437.1
FG978181.1
ES742301.1
FG980310.1
FG976214.1
EX010963.1
TDC00832_1
EX011938.1
FG978185.1
FG979212.1
EX916666.1
ES739005.1
Tcol_isotig00909
FG981096.1
ES412511.1
EX911188.1
ES413784.1
EX013487.1
FG978159.1
FG974064.1
CB037304.1
CBC05846_1
CB037954.1
FG979825.1
FG971277.1
HBC02089_2
EX910377.1
FG974047.1
FF681158.1
ES739700.1
ES743788.1
EX013459.1
Tcol_isotig00908
ES412392.1
ES740331.1
FF678175.1
ES740671.1
ES409212.1
CB037285.1
ES414207.1
ES412302.1
HBC11706_1
EX915046.1
FG975044.1
Dviv_isotig05646
FG978742.1
EX909968.1
FK807288.1
FG980574.1
FG980923.1
EX008041.1
FG978621.1
EX008743.1
BM052057.1
FG979246.1
Tcol_isotig08385
EX914072.1
ES744671.1
FF680863.1
FG979460.1
EX010564.1
FG977010.1
EV853844.1
FG979814.1
ES743375.1
CJC00851_1
ES740003.1
ES411982.1
MIC04401_1
FG977487.1
EX011211.1
ES413030.1
EX008132.1
CJC13522_1
EX010980.1
FG975083.1
GW406205.1
FG975948.1
FF681663.1
FG974626.1
ES742985.1
HBC10384_1
FF680021.1
HBC05625_1
Name_isotig05183
EX916809.1
EX914515.1
EX010179.1
EX009662.1
FF682063.1
EX011408.1
EX914378.1
FG972402.1
EX913181.1
FG971901.1
ES741760.1
ES739049.1
EX912639.1
FG980588.1
ES742012.1
FG979010.1
EX913733.1
TDC01767_1
FG974303.1
ES412427.1
EX916597.1
FG977298.1
EX912328.1
FG977981.1
EX910299.1
ES408930.1
FG973489.1
Tcol_isotig00904
FG970720.1
ES742183.1
FG974513.1
FG978184.1
ES414229.1
ES410422.1
EX912486.1
FG974731.1
ES742093.1
EX012262.1
EX008584.1
FG971752.1
FG978348.1
FF680872.1
FG974323.1
EX916690.1
Tcir_isotig09464
PSC00355
FG972849.1
FG972061.1
FG980237.1
FG976244.1
EX012242.1
ES413033.1
FG972184.1
FG980036.1
EX911062.1
FG977316.1
FG972140.1
FF680721.1
EX916259.1
FG979030.1
FK809490.1
FF681331.1
CSC00210_1
EX014868.1
EX010327.1
EX007470.1
FG973350.1
FG979247.1
FG972169.1
FG972114.1
EX912870.1
Tcir_isotig16887
CB038940.1
FK807536.1
EX014489.1
EG025554.1
EX912794.1
Tcol_isotig00906
FG980017.1
FG977279.1
FG975294.1
EX916558.1
ES409525.1
ES411100.1
ES411323.1
ES740225.1
Associated_featureWBsf662381
WBsf236202
Experimental_infoRNAi_resultWBRNAi00090691Inferred_automaticallyRNAi_primary
WBRNAi00051410Inferred_automaticallyRNAi_primary
WBRNAi00034675Inferred_automaticallyRNAi_primary
WBRNAi00075968Inferred_automaticallyRNAi_primary
WBRNAi00002134Inferred_automaticallyRNAi_primary
WBRNAi00017500Inferred_automaticallyRNAi_primary
Expr_patternExpr1968
Expr8654
Expr1013555
Expr1031338
Expr1155097
Expr2013041
Expr2031273
Drives_constructWBCnstr00013423
WBCnstr00036342
Construct_productWBCnstr00013423
WBCnstr00036342
AntibodyWBAntibody00002492
Microarray_results (18)
Expression_cluster (299)
Interaction (180)
Map_infoMapXPosition1.72773Error0.000844
PositivePositive_cloneR07B1Person_evidenceWBPerson763
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (14)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene