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WormBase Tree Display for Gene: WBGene00000298

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Name Class

WBGene00000298SMapS_parentSequenceCHROMOSOME_V
IdentityVersion1
NameCGC_namecat-4Person_evidenceWBPerson261
Sequence_nameF32G8.6
Molecular_nameF32G8.6
F32G8.6.1
CE05795
Other_namegtpch-1Paper_evidenceWBPaper00005354
CELE_F32G8.6Accession_evidenceNDBBX284605
Public_namecat-4
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcat
Reference_alleleWBVar00143773
AlleleWBVar02144113Inferred_automaticallyFrom strain object: LC141
WBVar02144114
WBVar01461524
WBVar01461525
WBVar02060792
WBVar01500097
WBVar00091640
WBVar00143773
WBVar01500129
WBVar01043528
WBVar01043529
WBVar01043530
WBVar01043531
WBVar01043532
WBVar01043533
WBVar01043534
WBVar01043535
WBVar01043536
WBVar00249801
WBVar01499450
WBVar01499451
WBVar01500208
WBVar01500209
WBVar00468926
WBVar00468927
WBVar00468928
WBVar00468929
WBVar01499316
Legacy_informatione1141 : dopamine reduced > 90%. ES1 ME2 NA1.
[Leon Avery] Serotonin is reduced or absent (CGC#1105).
See also e1141
[C.elegansII] e1141 : dopamine reduced > 90%, serotonin reduced orabsent; poor male turning behavior; enhanced foraging behavior, suppressed by serotonin agonists; serotonin immunoreactivity restored by exogenous serotonin or 5-hydroxytryptophan;cuticle defective, hypersensitive to SDS, levamisole,hypochlorite.. ES1 ME2 NA1. [Sulston et al. 1975; Loer and Kenyon 1993; DA; KP; LC]
StrainWBStrain00024111
WBStrain00024121
WBStrain00027351
WBStrain00004253
WBStrain00004816
WBStrain00024116
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (39)
Structured_descriptionAutomated_descriptionEnables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; dopaminergic neurons; hyp7 syncytium; intestinal cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; and movement disease (multiple). Is an ortholog of human GCH1 (GTP cyclohydrolase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (11)
Molecular_infoCorresponding_CDSF32G8.6
Corresponding_transcriptF32G8.6.1
Other_sequenceAM743589.1
OOC00024_4
AM743233.1
TDC00311_1
AM743290.1
AM743605.1
AM743343.1
AM743701.1
HC03251
Oden_isotig06064
PE00417
AM743828.1
OOC01399_7
BU666783.1
OOC00024_8
AM743700.1
HGC09147_1
AM743227.1
AM743560.1
AM743817.1
OOC01459_2
AM743367.1
OOC01399_1
AM743443.1
PEC00005_7
PE00075
OOC02228_1
AM743678.1
PE00268
PE00414
FG620559.1
Tcol_isotig12153
AM743931.1
TDC00338_1
AM743681.1
AM743714.1
OOC02217_1
OOC00024_1
TDC00412_3
AM743335.1
AM743932.1
AM743275.1
AM743442.1
OOC02998_1
AM743483.1
OOC01399_4
AM743513.1
JI182278.1
AM743622.1
AM743224.1
AM743432.1
AM743368.1
BU087833.1
AM743216.1
Acan_isotig11811
AM743503.1
AM743613.1
OOC00024_13
AM743795.1
AM743793.1
BG467651.1
AM743689.1
AM743436.1
AM743890.1
PEC00005_2
AM743452.1
OOC00024_16
AM743649.1
AM743604.1
BU088934.1
JI175194.1
OOC00024_6
AE04469
AM743346.1
BQ097967.1
TDC00338_2
AM743671.1
TDC03048_1
AM743632.1
Oden_isotig06063
AM743844.1
OOC02517_1
AM743792.1
AM743695.1
PEC00343_1
AM743268.1
AM743885.1
AM743493.1
AM743672.1
AM743878.1
PE00197
OVC01384_1
AM743637.1
PEC00005_3
AM743261.1
AM743568.1
AM743200.1
AM743321.1
AM743898.1
AM743709.1
JI235926.1
AM743487.1
OOC01604_1
FG620572.1
AM743907.1
TSC06379_1
AM743580.1
AM743939.1
PE00441
AM743397.1
AM743557.1
AM743379.1
AM743236.1
AM743528.1
PE00255
AM743238.1
AM743404.1
CB043041.1
AM743324.1
AM743501.1
AM743703.1
AM743461.1
AM743915.1
AM743650.1
AM743226.1
AM743895.1
TDC03174_1
AM743821.1
AM743534.1
AM743325.1
EX013814.1
AM743653.1
TDC03206_1
Tcir_isotig22569
FG620575.1
AM743744.1
AM743315.1
OOC02001_1
AM743912.1
AM743472.1
AM743595.1
AM743584.1
CJC02132_1
AM743731.1
AM743428.1
AM743673.1
AM743529.1
AM743427.1
AM743906.1
AM743720.1
AM743199.1
AM743262.1
AM743719.1
BU089231.1
PE00256
AM743824.1
AM743352.1
AM743541.1
TDC00412_1
FR726162.1
AM743232.1
AM743943.1
AM743526.1
AM743237.1
AM743278.1
AM743380.1
AM743899.1
OOC04008_1
AM743478.1
AM743338.1
AM743775.1
OOC00024_3
TDC00338_3
AM743897.1
AM743390.1
NB08822
AM743686.1
AM743642.1
OOC01399_3
AM743652.1
AM743524.1
AM743479.1
AM743692.1
AM743429.1
NAC00417_1
OOC01874_1
AM743838.1
AM743405.1
AM743889.1
AM743948.1
AM743840.1
PEC00005_6
PE00241
EY465710.1
AM743313.1
OOC00024_7
AM743626.1
AM743609.1
AM743593.1
AM743664.1
AM743606.1
AM743482.1
AM743732.1
OOC02606_1
Tcir_isotig06655
ACC00523_1
ACC09306_1
AM743408.1
TDC00412_2
EY469173.1
AM743587.1
TDC02651_1
OOC00024_10
AM743610.1
AM743360.1
AM743805.1
AM743356.1
AM743392.1
AM743355.1
AM743520.1
HCC12941_1
OOC01604_2
ACC03735_1
AM743480.1
AM743748.1
FG584912.1
OOC01853_1
SS00093
AM743547.1
AM743937.1
TDC00311_2
AM743440.1
PEC00005_4
AM743769.1
CBC02607_1
TDC02554_1
AM743783.1
AM743607.1
AM743860.1
AM743853.1
AM743246.1
ACC02432_1
OOC00024_17
AM743662.1
AI111235.1
AM743814.1
AM743717.1
OOC00024_18
HC01637
AM743608.1
AM743231.1
OOC02996_1
AM743781.1
AM743570.1
Tcir_isotig11220
OOC02863_1
AM743787.1
OOC02633_1
AM743562.1
AM743206.1
AM743476.1
AM743358.1
OOC02840_1
TDC00338_4
AM743647.1
AM743298.1
AM743811.1
AM743391.1
AM743918.1
AM743308.1
OOC02658_1
AM743707.1
AM743253.1
AM743594.1
AM743845.1
AM743318.1
AM743586.1
OOC02781_1
AM743913.1
NBC02834_1
OOC00024_9
AM743561.1
OOC04004_1
OOC00024_20
AM743477.1
AM743453.1
AM743400.1
TDC02380_2
FG620570.1
BU666034.1
AM743724.1
AM743753.1
AM743377.1
PE00261
OOC02283_1
OOC01604_3
AM743551.1
OOC01459_1
AM743305.1
AM743506.1
AM743863.1
AM743366.1
AM743903.1
FG351670.1
TDC02502_1
AM743660.1
AM743723.1
AM743830.1
AM743921.1
AM743721.1
BU087137.1
CA840830.1
OOC00024_2
OOC00024_12
ES739951.1
FG620561.1
Hbac_isotig03874
OOC01881_1
AM743579.1
AM743763.1
OOC01399_6
PEC00005_5
ES742289.1
XIC03407_1
AM743384.1
AF052048.1
AM743745.1
AM743928.1
Dviv_isotig27991
AM743389.1
ACC32827_1
OOC00024_19
OOC01399_2
AM743949.1
TDC02388_1
AM743752.1
HG10387
AM743344.1
AM743758.1
OOC00024_11
AM743879.1
AM743539.1
AM743944.1
AM743848.1
AM743350.1
AM743785.1
FG620564.1
AM743454.1
OOC01401_1
AM743854.1
AM743894.1
OOC02704_1
AM743267.1
PEC00005_1
PEC00280_1
AM743588.1
OOC01970_1
AM743881.1
BQ097526.1
AM743357.1
AM743869.1
AM743522.1
AM743666.1
TDC02380_4
AM743517.1
TDC03217_1
AM743219.1
OOC01399_5
TDC02380_3
AM743498.1
AM743682.1
XI02709
AM743675.1
AM743466.1
AM743245.1
AM743294.1
OOC01831_1
AM743329.1
AM743767.1
AM743820.1
AM743396.1
FG349136.1
AM743849.1
AM743471.1
OOC00024_14
OOC00024_15
AM743927.1
AM743348.1
SSC01938_1
AM743597.1
AM743776.1
AM743387.1
JI178925.1
AM743585.1
AM743240.1
HCC00813_1
Name_isotig01469
AM743669.1
AM743484.1
AM743871.1
AM743737.1
AM743316.1
AM743683.1
OOC00024_5
AM743495.1
CB043187.1
AM743716.1
AM743297.1
OOC02411_1
TDC02380_1
HBC06685_1
OOC02552_1
AM743668.1
Associated_featureWBsf047518
WBsf047519
WBsf047520
WBsf1001139
WBsf1020318
WBsf232395
Experimental_infoRNAi_resultWBRNAi00031695Inferred_automaticallyRNAi_primary
WBRNAi00115602Inferred_automaticallyRNAi_primary
WBRNAi00014232Inferred_automaticallyRNAi_primary
WBRNAi00115714Inferred_automaticallyRNAi_primary
WBRNAi00046157Inferred_automaticallyRNAi_primary
WBRNAi00115603Inferred_automaticallyRNAi_primary
WBRNAi00115701Inferred_automaticallyRNAi_primary
Expr_patternExpr4817
Expr12165
Expr1027591
Expr1150045
Expr2009728
Expr2027967
Drives_constructWBCnstr00012257
WBCnstr00015879
WBCnstr00017075
WBCnstr00020335
WBCnstr00037596
Construct_productWBCnstr00012257
WBCnstr00037596
Microarray_results (19)
Expression_cluster (261)
Interaction (175)
Map_infoMapVPosition2.59941Error0.001738
PositivePositive_cloneF32G8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point151
1529
2269
Pos_neg_data6765
6766
6767
6769
6771
Reference (94)
RemarkInteracting_genes '[Leon Avery] unc-31: cat-4 enhances the Egl defect of unc-31 mutants, especially at 15C.
MethodGene