WormBase Tree Display for Gene: WBGene00000018

WBGene00000018 SMap: S_parent: Sequence: M79
  Identity: Version: 1
    Name: CGC_name: abl-1
      Sequence_name: M79.1
      Molecular_name (24)
      Other_name: CELE_M79.1 Accession_evidence: NDB BX284606
      Public_name: abl-1
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: abl
    Allele: WBVar00146372
      WBVar00146370
      WBVar00090313
      WBVar01182359
      WBVar00515508
      WBVar00515509
      WBVar01182360
      WBVar00515510
      WBVar01182361
      WBVar01182362
      WBVar00515511
      WBVar01182363
      WBVar00515512
      WBVar00515513
      WBVar01182364
      WBVar00515514
      WBVar01182365
      WBVar01182366
      WBVar00515515
      WBVar02088401
      WBVar00515516
      WBVar01182367
      WBVar01182368
      WBVar00515517
      WBVar01182369
      WBVar00515518
      WBVar00515519
      WBVar01182370
      WBVar01182371
      WBVar00515520
      WBVar01182372
      WBVar00515521
      WBVar01182373
      WBVar00515522
      WBVar00515523
      WBVar01182374
      WBVar00515524
      WBVar01182375
      WBVar00515525
      WBVar01182376
      WBVar00515526
      WBVar01182377
      WBVar01182378
      WBVar00515527
      WBVar00315957
      WBVar01182379
      WBVar00515528
      WBVar00515529
      WBVar00515530
      WBVar00515531
      WBVar00236724
      WBVar00515532
      WBVar00236725
      WBVar00515533
      WBVar02079392
      WBVar00515534
      WBVar02065970
      WBVar00515535
      WBVar02065971
      WBVar00515536
      WBVar02065972
      WBVar00515537
      WBVar00515538
      WBVar02065973
      WBVar00515539
      WBVar00515540
      WBVar00515541
      WBVar01888837
      WBVar01487588
      WBVar00515542
      WBVar01888838
      WBVar01487589
      WBVar01888839
      WBVar00515543
      WBVar01487590
      WBVar01487591
      WBVar01888840
      WBVar00515544
      WBVar01888841
      WBVar00515545
      WBVar01888842
      WBVar00515546
      WBVar01888843
      WBVar01888844
      WBVar01888845
      WBVar01888846
      WBVar01888847
      WBVar01888848
      WBVar01888849
      WBVar01888850
      WBVar01888851
      WBVar01888852
      WBVar01888853
      WBVar01888854
      WBVar01888855
      WBVar01888856
      WBVar01888857
      WBVar01888858
      WBVar01888859
      WBVar01888860
      WBVar01888861
      WBVar01816800
      WBVar01888862
      WBVar01888863
      WBVar01888864
      WBVar01620348
      WBVar01888865
      WBVar01620349
      WBVar01620350
      WBVar01888866
      WBVar01888867
      WBVar01620351
      WBVar01527661
      WBVar01888868
      WBVar00233822
      WBVar01888869
      WBVar01981257
      WBVar01888870
      WBVar00233823
      WBVar01888871
      WBVar01981258
      WBVar01888872
      WBVar01888873
      WBVar00082642
      WBVar02116629
      WBVar00082644
      WBVar00082645
      WBVar00082646
      WBVar00082647
      WBVar00082648
      WBVar00082649
      WBVar00265990
      WBVar01470878
      WBVar00082650
      WBVar01182260
      WBVar01470879
      WBVar01182261
      WBVar00082651
      WBVar01182262
      WBVar01470880
      WBVar00082653
      WBVar00082654
      WBVar01182263
      WBVar01470882
      WBVar01182264
      WBVar00082655
      WBVar01470883
      WBVar01182265
      WBVar01470884
      WBVar01470885
      WBVar01182266
      WBVar01494270
      WBVar01182267
      WBVar01470886
      WBVar01182268
      WBVar01182269
      WBVar01182270
      WBVar01182271
      WBVar01182272
      WBVar00068644
      WBVar01182273
      WBVar01182274
      WBVar01182275
      WBVar01182276
      WBVar01544536
      WBVar01182277
      WBVar01182278
      WBVar01182279
      WBVar01182280
      WBVar01182281
      WBVar01182282
      WBVar01182283
      WBVar01182284
      WBVar01182285
      WBVar01182286
      WBVar00064094
      WBVar01182287
      WBVar01182288
      WBVar01759276
      WBVar01182289
      WBVar01182290
      WBVar00064099
      WBVar01759277
      WBVar01182291
      WBVar01759278
      WBVar01759279
      WBVar01182292
      WBVar00064104
      WBVar01928183
      WBVar01182293
      WBVar01182294
      WBVar01845977
      WBVar01928184
      WBVar01182295
      WBVar01928185
      WBVar01182296
      WBVar00064109
      WBVar01928186
      WBVar01928187
      WBVar01182297
      WBVar01182298
      WBVar01928188
      WBVar01928189
      WBVar01182299
      WBVar01928190
      WBVar01182300
      WBVar01928191
      WBVar00064119
      WBVar01182301
      WBVar01182302
      WBVar01182303
      WBVar00064124
      WBVar01182304
      WBVar01182305
      WBVar01182306
      WBVar01182307
      WBVar00264197
      WBVar02027373
      WBVar01182308
      WBVar01602140
      WBVar02027374
      WBVar01182309
      WBVar01602141
      WBVar02027375
      WBVar01182310
      WBVar01182311
      WBVar00091489
      WBVar02069064
      WBVar01182312
      WBVar01551980
      WBVar01499286
      WBVar01182313
      WBVar01551981
      WBVar00099872
      WBVar01499287
      WBVar00099873
      WBVar01182314
      WBVar01551982
      WBVar01182315
      WBVar01551983
      WBVar01182316
      WBVar01551984
      WBVar01182317
      WBVar01551985
      WBVar01551986
      WBVar01182318
      WBVar01551987
      WBVar01182319
      WBVar01551988
      WBVar01182320
      WBVar01551989
      WBVar01182321
      WBVar01897884
      WBVar01182322
      WBVar01182323
      WBVar01897885
      WBVar01897886
      WBVar01182324
      WBVar01897887
      WBVar01987649
      WBVar01182325
      WBVar01182326
      WBVar01897888
      WBVar01987650
      WBVar01897889
      WBVar01182327
      WBVar01897890
      WBVar01182328
      WBVar01897891
      WBVar01182329
      WBVar01182330
      WBVar01897892
      WBVar01182331
      WBVar01182332
      WBVar01182333
      WBVar01182334
      WBVar01182335
      WBVar01182336
      WBVar00090310
      WBVar01182337
      WBVar01182338
      WBVar00090312
      WBVar01182339
      WBVar01182340
      WBVar01182341
      WBVar01182342
      WBVar01182343
      WBVar01182344
      WBVar02009057
      WBVar01182345
      WBVar01182346
      WBVar01182347
      WBVar01182348
      WBVar01182349
      WBVar01690204
      WBVar01182350
      WBVar01690205
      WBVar01182351
      WBVar01182352
      WBVar01182353
      WBVar01182354
      WBVar00515504
      WBVar01498960
      WBVar01182355
      WBVar01182356
      WBVar00515505
      WBVar00515506
      WBVar01182357
      WBVar00259095
      WBVar01500067
      WBVar01182358
      WBVar00515507
    Legacy_information: [C.elegansII] NMK. Major transcript 4.4 kb; sequence (~400 aa) has 62% identity with oncogene v-abl in predicted kinase domain. [Goddard et al. 1986]
    Strain: WBStrain00002968
      WBStrain00040670
      WBStrain00040671
      WBStrain00040673
    RNASeq_FPKM (74)
    GO_annotation (65)
    Ortholog (35)
    Paralog (45)
    Structured_description: Concise_description: abl-1 encodes, by alternative splicing, three isoforms of a Src homology(SH) 2 and 3 domain-containing non-receptor tyrosine kinase orthologousto human ABL1 (OMIM:189980, mutated in chronic myeloid leukemia) andABL2 (OMIM:164690); ABL-1 inhibits germline apoptosis induced byradiation or by natural aging, but it has no effect on apoptosis inducedby starvation or by chemical mutagens (ethylnitrosourea,ethylmethanesulfonate, cisplatin, etoposide), or on constitutive('physiological') germline apoptosis; at the same time, ABL-1 isrequired for germline apoptosis induced by oxidative, osmotic orheat-shock stress, and is also required for pathogenesis by Shigellaflexneri infecting the intestine; ABL-1-inhibited apoptosis is confinedto a single gonad arm undergoing radiation, having no nonautonomouseffect on the unirradiated arm; abl-1 is expressed in the germline, inmost or all cells of early embryos, and in postembryonic pharynx, tailganglia and ventral nerve cord; abl-1(ok171) mutants are hypersensitiveto germline apoptosis and resistant to S. flexneri infection; bothabl-1(ok171) phenotypes are phenocopied by c-ABL inhibitors such asSTI-571 (Gleevec); ABL-1-inhibited apoptosis requires active CED-3 andEGL-1, inactive CED-9, and active AKT-1, CEP-1, CLK-1, HUS-1, and MRT-2;abl-1(ok171) has no effect on somatic apoptosis, and abl-1(ok171)mutants are generally normal; abl-1 transcripts are enriched in culturedunc-4::GFP neurons. Paper_evidence: WBPaper00024301
            WBPaper00025141
            WBPaper00027170
            WBPaper00027648
            WBPaper00027729
            WBPaper00029085
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 16 Apr 2007 00:00:00
      Automated_description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including defense response to other organism; negative regulation of DNA damage response, signal transduction by p53 class mediator; and negative regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Expressed in Q cell; germ cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Is an ortholog of human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:8552 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:0080630 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:76)
  Molecular_info: Corresponding_CDS: M79.1a
      M79.1b
      M79.1c
      M79.1d
      M79.1e
      M79.1f
      M79.1g
      M79.1h
    Corresponding_CDS_history: M79.1a:wp83
      M79.1b:wp83
      M79.1c:wp83
    Corresponding_transcript: M79.1a.1
      M79.1b.1
      M79.1c.1
      M79.1d.1
      M79.1e.1
      M79.1f.1
      M79.1g.1
      M79.1h.1
    Other_sequence: ACC11446_1
      MH06257
      TM01377
      JI169172.1
      EX548009.1
      Name_isotig09115
      Oden_isotig17235
      TMC01008_1
      CR09951
      CR09999
      JI165020.1
      CRC03322_1
      CR09872
      Oden_isotig17236
      MHC02694_1
      CRC10628_1
      CRC12454_1
      Dviv_isotig23403
      JI169455.1
      CJC12721_1
      TM03542
    Associated_feature (22)
  Experimental_info: RNAi_result (16)
    Expr_pattern: Chronogram1126
      Expr3045
      Expr4844
      Expr13648
      Expr1013054
      Expr1030006
      Expr1154769
      Expr2009093
      Expr2027329
    Drives_construct: WBCnstr00000775
      WBCnstr00003474
      WBCnstr00011096
      WBCnstr00012272
      WBCnstr00037793
    Construct_product: WBCnstr00000775
      WBCnstr00037793
    Microarray_results (32)
    Expression_cluster (112)
    Interaction (130)
    WBProcess: WBbiopr:00000014
      WBbiopr:00000066
      WBbiopr:00000104
  Map_info: Map: X Position: 2.34106 Error: 0.006695
    Positive: Positive_clone: M79 Inferred_automatically: From sequence, transcript, pseudogene data
        MC#191
    Mapping_data: Multi_point: 4134
        4652
    Pseudo_map_position
  Reference (48)
  Method: Gene