WormBase Tree Display for Gene: WBGene00006368

WBGene00006368 SMap: S_parent: Sequence: C54H2
  Identity: Version: 1
    Name: CGC_name: sym-3 Person_evidence: WBPerson252
      Sequence_name: C54H2.1
      Molecular_name: C54H2.1a
        C54H2.1a.1
        CE38303
        C54H2.1b
        CE38304
        C54H2.1a.2
        C54H2.1b.1
        C54H2.1b.2
      Other_name: CELE_C54H2.1 Accession_evidence: NDB BX284606
      Public_name: sym-3
    DB_info: Database: WormQTL gene WBGene00006368
        WormFlux gene WBGene00006368
        NDB locus_tag CELE_C54H2.1
        Panther gene CAEEL|WormBase=WBGene00006368|UniProtKB=Q86GI2
          family PTHR21456
        NCBI gene 183819
        RefSeq protein NM_001029329.8
            NM_001029330.3
        TREEFAM TREEFAM_ID TF320966
        TrEMBL UniProtAcc Q86GI2
            G5EE38
        UniProt_GCRP UniProtAcc Q86GI2
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sym
    Allele: WBVar02125279
      WBVar02050602
      WBVar01149762
      WBVar01149763
      WBVar01149764
      WBVar01550033
      WBVar01149765
      WBVar01149766
      WBVar01149767
      WBVar01149768
      WBVar01149769
      WBVar01149770
      WBVar01149771
      WBVar01149772
      WBVar01149773
      WBVar01149774
      WBVar01149775
      WBVar01149776
      WBVar01149777
      WBVar01149778
      WBVar01149779
      WBVar01149780
      WBVar00079390
      WBVar00079391
      WBVar00079392
      WBVar00079393
      WBVar00079394
      WBVar02063981
      WBVar02063982
      WBVar02063983
      WBVar02063984
      WBVar02086811
      WBVar00504552
      WBVar00504553
      WBVar00504554
      WBVar00504555
      WBVar00504556
      WBVar00504557
      WBVar00504558
      WBVar00504559
      WBVar01980728
      WBVar00504560
      WBVar00504561
      WBVar00504562
      WBVar00504563
      WBVar00504564
      WBVar01880076
      WBVar01880077
      WBVar01880078
      WBVar01880079
      WBVar01880080
      WBVar01880081
      WBVar01880082
      WBVar01880083
      WBVar02139348
      WBVar01880084
      WBVar01880085
      WBVar01820919
      WBVar01880086
      WBVar01880087
      WBVar01880088
      WBVar01880089
      WBVar01880090
      WBVar01820010
      WBVar02141207
      WBVar00089185
      WBVar01500067
    Legacy_information: [Herman RK] sym-3(mn618) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation
    Strain: WBStrain00034405
      WBStrain00034416
    RNASeq_FPKM (74)
    Ortholog: WBGene00051623 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00035152 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00150809 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00096559 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00134757 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00223207 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2622 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g14402 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g7764 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g10592 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g2561 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g16019 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g172 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g10423 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g7951 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g14009 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-sym-3 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold626.g6574 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00027.g1556 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00465 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024469 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04380 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g20014 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0234600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19118 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00240033 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00258408 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00289519 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000182 Saccharomyces cerevisiae From_analysis: OrthoFinder
            Panther
      FB:FBgn0032938 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-041014-330 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060616-312 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060929-412 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-081104-233 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:27637 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:31419 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2138935 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:3036259 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310037 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1597535 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: sym-3 encodes, by alternative splicing, two isoforms of a protein withno recognizably conserved domains, but with orthology to human FAM102A (EEIG1; OMIM:610891) and FAM102B, and to Drosophila CG8671; mutations in sym-3, while producing no phenotype on their own, are synthetically lethal with loss-of-function mutations in mec-8, which encodes a regulator of alternative RNA splicing; although the precise function of sym-3 is not yet known, sym-3 activity appears to be required for some aspects of pharyngeal differentiation, as mec-8; sym-3 double mutants arrest as late-stage embryos or L1 larvae with pharynges that, despite normal morphology, do not attach to the outer cuticle to allow for feeding. Paper_evidence: WBPaper00003663
            WBPaper00024639
          Curator_confirmed: WBPerson1843
          Date_last_updated: 04 May 2006 00:00:00
      Automated_description: Enriched in several structures, including ABalapapapa; ABalapppapa; ABplpaaappa; ABprpaaappa; and head neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-12; and eat-2 based on microarray; RNA-seq; and tiling array studies. Is affected by eight chemicals including Lithium Chloride; Zidovudine; and allantoin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: NT-type C2 domain; EEIG1/2-like; and N-terminal C2 in EEIG1 and EHBP1 proteins. Is an ortholog of human EEIG1 (estrogen-induced osteoclastogenesis regulator 1) and EEIG2 (EEIG family member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C54H2.1a
      C54H2.1b
    Corresponding_CDS_history: C54H2.1:wp107
      C54H2.1:wp141
    Corresponding_transcript: C54H2.1a.1
      C54H2.1a.2
      C54H2.1b.1
      C54H2.1b.2
    Other_sequence (21)
    Associated_feature: WBsf1005379
      WBsf1005380
      WBsf1023007
  Experimental_info: RNAi_result: WBRNAi00043193 Inferred_automatically: RNAi_primary
      WBRNAi00030166 Inferred_automatically: RNAi_primary
      WBRNAi00062556 Inferred_automatically: RNAi_primary
      WBRNAi00062555 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1020038
      Expr1032567
      Expr1147171
      Expr2017181
      Expr2035317
    Drives_construct: WBCnstr00034386
    Construct_product: WBCnstr00016047
      WBCnstr00034386
    Microarray_results (27)
    Expression_cluster (82)
    Interaction: WBInteraction000052796
      WBInteraction000134120
      WBInteraction000134122
      WBInteraction000142067
      WBInteraction000318693
      WBInteraction000434495
  Map_info: Map: X Position: -4.37222 Error: 0.007269
    Positive: Positive_clone: C54H2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 7092
        7093
  Reference (16)
  Method: Gene