tpi-1 encodes a putative triosephosphate isomerase orthologous to human TPI1 (OMIM:190450, mutated in TPI deficiency) and Drosophila WASTED AWAY; loss of tpi-1 activity via RNAi results in increased resistance to exogenous oxidants and shortening of natural adult lifespan, both presumably due to alterations in the redox state of cells.
Predicted to enable methylglyoxal synthase activity and triose-phosphate isomerase activity. Involved in cell redox homeostasis and determination of adult lifespan. Located in myofibril. Human ortholog(s) of this gene implicated in triosephosphate isomerase deficiency. Is an ortholog of human TPI1 (triosephosphate isomerase 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.