WormBase Tree Display for Gene: WBGene00013955

WBGene00013955 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: kri-1 Person_evidence: WBPerson137
      Sequence_name: ZK265.1
      Molecular_name: ZK265.1a
        ZK265.1a.1
        CE37865
        ZK265.1b
        CE37866
        ZK265.1b.1
      Other_name: CELE_ZK265.1 Accession_evidence: NDB BX284601
      Public_name: kri-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 15 Sep 2004 14:36:01 WBPerson1971 Name_change: CGC_name: kri-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kri
    Allele: WBVar00654131
      WBVar00654132
      WBVar00654133
      WBVar01475781
      WBVar00654134
      WBVar01475782
      WBVar00654135
      WBVar01340968
      WBVar00654136
      WBVar00654137
      WBVar00092497
      WBVar00654138
      WBVar00654139
      WBVar00654140
      WBVar00654141
      WBVar00654142
      WBVar00654143
      WBVar00654144
      WBVar00654145
      WBVar00654146
      WBVar01622880
      WBVar00654147
      WBVar00654148
      WBVar00654149
      WBVar00654150
      WBVar02127989
      WBVar00654151
      WBVar00262430
      WBVar00654152
      WBVar00654153
      WBVar00654154
      WBVar00654155
      WBVar00654156
      WBVar01909941
      WBVar00654157
      WBVar00654158
      WBVar01499175
      WBVar00654159
      WBVar01499176
      WBVar01499737
      WBVar01500105
      WBVar01499739
      WBVar01957338
      WBVar01957339
      WBVar01911836
      WBVar01704868
      WBVar01911837
      WBVar01911838
      WBVar01822908
      WBVar01499786
      WBVar01499054
      WBVar02148162
      WBVar00654077
      WBVar00654078
      WBVar00654079
      WBVar00654080
      WBVar00654081
      WBVar00339739
      WBVar00654082
      WBVar00339740
      WBVar00654083
      WBVar00339741
      WBVar00654084
      WBVar00654085
      WBVar00339742
      WBVar00339743
      WBVar00654086
      WBVar00339744
      WBVar00654087
      WBVar00339745
      WBVar00654088
      WBVar00339746
      WBVar00654089
      WBVar01432277
      WBVar00654090
      WBVar01432278
      WBVar00339747
      WBVar00339748
      WBVar00654091
      WBVar01432279
      WBVar00654092
      WBVar01432280
      WBVar00154984
      WBVar00339749
      WBVar00654093
      WBVar00154985
      WBVar00339750
      WBVar00154986
      WBVar00654094
      WBVar00339751
      WBVar00154987
      WBVar00654095
      WBVar00339752
      WBVar00339753
      WBVar00154988
      WBVar00654096
      WBVar00339754
      WBVar00654097
      WBVar00339755
      WBVar00654098
      WBVar00654099
      WBVar00339756
      WBVar00654100
      WBVar00339757
      WBVar00339758
      WBVar00654101
      WBVar00339759
      WBVar00654102
      WBVar00654103
      WBVar00654104
      WBVar00654105
      WBVar00654106
      WBVar00654107
      WBVar00654108
      WBVar00654109
      WBVar00654110
      WBVar00654111
      WBVar00654112
      WBVar00654113
      WBVar00654114
      WBVar00654115
      WBVar00654116
      WBVar00654117
      WBVar00654118
      WBVar00654119
      WBVar00654120
      WBVar00654121
      WBVar00654122
      WBVar00654123
      WBVar00598015
      WBVar00654124
      WBVar00654125
      WBVar01498959
      WBVar00654126
      WBVar00654127
      WBVar00654128
      WBVar00654129
      WBVar00654130
    Strain: WBStrain00004908
      WBStrain00004911
      WBStrain00031903
      WBStrain00004889
      WBStrain00004892
      WBStrain00004896
      WBStrain00004905
      WBStrain00004910
    RNASeq_FPKM (74)
    GO_annotation: 00014051
      00014052
      00014053
      00014054
      00014055
      00014056
      00014057
      00014058
    Ortholog (32)
    Paralog: WBGene00001495 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00001496 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: kri-1 encodes an ankyrin repeat and FERM domain-containing protein orthologous to human KRIT1 (Krev interaction trapped/cerebral cavernous malformation 1, OMIM:604214); kri-1 was identified in RNAi screens for genes required for DAF-16-dependent lifespan extension in germline-depleted animals; subsequent analysis of kri-1 mutations suggests that KRI-1 is required for proper localization of DAF-16 in the intestine in response to germline loss; a rescuing KRI-1::GFP construct is expressed in larval and adult stages in pharyngeal and intestinal cells; the KRI-1::GFP is generally diffuse, but also localizes to apical and apicolateral cell surfaces as well as to intestinal nuclei in some animals. Paper_evidence: WBPaper00027158
          Curator_confirmed: WBPerson1843
          Date_last_updated: 10 Apr 2008 00:00:00
      Automated_description: Involved in positive regulation of gene expression. Located in apical plasma membrane; apicolateral plasma membrane; and nucleus. Expressed in intestine and pharynx. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 1. Is an ortholog of human KRIT1 (KRIT1 ankyrin repeat containing). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0060669 Homo sapiens Paper_evidence: WBPaper00059910
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Sep 2020 00:00:00
    Potential_model: DOID:0060669 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1573)
      DOID:0080491 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1573)
  Models_disease_asserted: WBDOannot00000808
  Molecular_info (5)
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr3841
      Expr1017543
      Expr1036238
      Expr1162743
      Expr2012980
      Expr2031212
    Drives_construct: WBCnstr00001012
      WBCnstr00001013
      WBCnstr00001014
      WBCnstr00022940
      WBCnstr00029417
    Construct_product: WBCnstr00001012
      WBCnstr00001013
      WBCnstr00001014
      WBCnstr00022940
      WBCnstr00029417
    Regulate_expr_cluster: WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated
      WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_upregulated
      WBPaper00056586:kri-1(ok1251)_downregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056586:KRI-1_interacting
    Microarray_results (27)
    Expression_cluster (106)
    Interaction: WBInteraction000008643
      WBInteraction000339772
      WBInteraction000361622
      WBInteraction000504269
      WBInteraction000520525
      WBInteraction000520963
      WBInteraction000520964
      WBInteraction000525055
      WBInteraction000525056
      WBInteraction000525169
      WBInteraction000560396
      WBInteraction000560397
      WBInteraction000560398
      WBInteraction000560399
      WBInteraction000560400
      WBInteraction000580872
    WBProcess: WBbiopr:00000121
  Map_info: Map: I Position: 2.70099 Error: 0.000625
    Positive: Positive_clone: ZK265 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4950
        5076
    Pseudo_map_position
  Reference (36)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene