WormBase Tree Display for Gene: WBGene00006954

WBGene00006954 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 1
    Name: CGC_name: wrt-8 Person_evidence: WBPerson83
      Sequence_name: C29F3.2
      Molecular_name: C29F3.2
        C29F3.2.1
        CE29200
      Other_name: cm20F10 Paper_evidence: WBPaper00002823
        CELE_C29F3.2 Accession_evidence: NDB BX284605
      Public_name: wrt-8
    DB_info: Database: AceView gene 5P822
        WormQTL gene WBGene00006954
        WormFlux gene WBGene00006954
        NDB locus_tag CELE_C29F3.2
        Panther gene CAEEL|WormBase=WBGene00006954|UniProtKB=Q94130
          family PTHR46706
        NCBI gene 180035
        RefSeq protein NM_074404.6
        SwissProt UniProtAcc Q94130
        TREEFAM TREEFAM_ID TF316084
        UniProt_GCRP UniProtAcc Q94130
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: wrt
    Allele: WBVar01809198
      WBVar01493077
      WBVar01493078
      WBVar00591479
      WBVar01498664
      WBVar01776965
      WBVar01073181
      WBVar01073182
      WBVar01073183
      WBVar01073184
      WBVar01073185
      WBVar01073186
      WBVar01073187
      WBVar01500160
      WBVar01073188
      WBVar01073189
      WBVar01073190
      WBVar01073191
      WBVar01073192
      WBVar01073193
      WBVar01073194
      WBVar00603008
      WBVar00478823
      WBVar00478824
      WBVar00478825
      WBVar00478826
      WBVar00478827
      WBVar00250570
      WBVar01500212
      WBVar01500213
      WBVar01463392
      WBVar01499299
      WBVar00601202
      WBVar01499316
      WBVar01745047
      WBVar01800343
      WBVar01745048
      WBVar01800344
      WBVar01745049
      WBVar01745050
      WBVar01745051
      WBVar01745052
      WBVar01745053
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (25)
    Paralog (24)
    Structured_description: Concise_description: wrt-8 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Wart domain, an short region of low-complexitysequence, and a Hint/Hog domain; WRT-8 is strongly expressed inhypodermal syncytia hyp6-hyp10 throughout life, and in in 12 subventralP cells and their descendants from 3-fold embryo to L2 larva stages; theHint/Hog domain is predicted to cut WRT-8 into two halves and thencovalently link cholesterol to the C-terminus of the Wart domain; theWart domain is predicted to form a cysteine-crosslinked protein involvedin intercellular signalling, and it has subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; WRT-8 has no obviousfunction in RNAi assays. Paper_evidence: WBPaper00003717
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in hyp10; hyp6; hyp7 syncytium; hyp8; and hyp9. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C29F3.2
    Corresponding_CDS_history: C29F3.2:wp12
      C29F3.2:wp63
    Corresponding_transcript: C29F3.2.1
    Other_sequence: Dviv_isotig16933
      SS01151
      SSC04002_1
      Dviv_isotig16932
    Associated_feature: WBsf653445
      WBsf669773
      WBsf1002264
      WBsf1020997
      WBsf235051
      WBsf235052
  Experimental_info: RNAi_result: WBRNAi00011331 Inferred_automatically: RNAi_primary
      WBRNAi00076987 Inferred_automatically: RNAi_primary
      WBRNAi00041461 Inferred_automatically: RNAi_primary
      WBRNAi00027687 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr648
      Expr1012897
      Expr1032965
      Expr1145490
      Expr2018083
      Expr2036221
    Drives_construct: WBCnstr00012473
      WBCnstr00034074
    Construct_product: WBCnstr00034074
    Microarray_results (16)
    Expression_cluster: WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040285:H2S_12hr_downregulated
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00042194:Tryptophan_downregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045017:blmp-1(tm548)_downregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045774:clk-1_upregulated_CoQ10_dependent
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00049018:ham-3(RNAi)_downregulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050709:jmjd-1.2(tm3713)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050743:elli-1(sam-3)_downregulated
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050801:SET-4_dauer_regulome
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055013:hmg-4(RNAi)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L3
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-6(t1903)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056330:glycine_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059231:alh-6(lax105)_L4_upregulated
      WBPaper00059253:stearic-acid_downregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059426:SiO2-nanoparticles_upregulated
      WBPaper00059566:wdr-23(mac32)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060479:sid-2(mj465)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:skpo-1(ok1640)_upregulated_OP50
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Hypodermis
      WBPaper00061340:Tail_hypodermis
      WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
      WBPaper00061390:N2_ascarosides_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:dos-2-grd-2
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
      WBPaper00061653:alh-4(hj221)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062347:blmp-1(tm548)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066093:E.coli-purE_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_20
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_E
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00032948:FedUp
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040876:mir-35_downregulated
      WBPaper00041207:CE_dauer_down
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_B
    Interaction (73)
    WBProcess: WBbiopr:00000123
  Map_info: Map: V Position: 7.86062 Error: 0.005823
    Positive: Positive_clone: C29F3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4966
        5380
        5413
    Pseudo_map_position
  Reference (11)
  Remark: C09F3.d is wrong (typo?) and .d gene has been superceded. being changed to C29F3.2 a hedghog gene.[sdm 000904]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene