WormBase Tree Display for Gene: WBGene00004029

WBGene00004029 SMap: S_parent: Sequence: K09B11
  Identity: Version: 2
    Name: CGC_name: pik-1 Person_evidence: WBPerson1122
      Sequence_name: K09B11.1
      Molecular_name: K09B11.1a
        K09B11.1a.1
        CE31033
        K09B11.1b
        CE45959
        K09B11.1a.2
        K09B11.1b.1
        K09B11.1c
      Other_name: CELE_K09B11.1 Accession_evidence: NDB BX284604
      Public_name: pik-1
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 15 Aug 2011 12:02:42 WBPerson4025 Event: Acquires_merge: WBGene00206467
      Acquires_merge: WBGene00206467
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pik
    Allele: WBVar01488659
      WBVar00306885
      WBVar01482592
      WBVar01482593
      WBVar01498996
      WBVar00575278
      WBVar00575284
      WBVar01499925
      WBVar01549131
      WBVar01581972
      WBVar01581973
      WBVar01581974
      WBVar01581975
      WBVar00954022
      WBVar00954023
      WBVar00954024
      WBVar00954025
      WBVar00954026
      WBVar00954027
      WBVar00954028
      WBVar00954029
      WBVar00954030
      WBVar00954031
      WBVar02099683
      WBVar00954032
      WBVar00954033
      WBVar00954034
      WBVar01499951
      WBVar00954035
      WBVar01499952
      WBVar02037481
      WBVar00954036
      WBVar00954037
      WBVar00251059
      WBVar01967521
      WBVar02037482
      WBVar00954038
      WBVar01967522
      WBVar01967523
      WBVar00954039
      WBVar00954040
      WBVar01967524
      WBVar01796564
      WBVar00954041
      WBVar01967525
      WBVar01796565
      WBVar01796566
      WBVar01967526
      WBVar00954042
      WBVar01967527
      WBVar00954043
      WBVar00954044
      WBVar00954045
      WBVar00091381
      WBVar00954046
      WBVar00954047
      WBVar00954048
      WBVar00954049
      WBVar00954050
      WBVar00954051
      WBVar00954052
      WBVar01805056
      WBVar01805057
      WBVar01805058
      WBVar01805059
      WBVar01805060
      WBVar01805061
      WBVar02008432
      WBVar01805062
      WBVar02008433
      WBVar01805063
      WBVar02008434
      WBVar01805064
      WBVar02008435
      WBVar01805065
      WBVar01805066
      WBVar01805067
      WBVar01805068
      WBVar02047165
      WBVar02047166
      WBVar02047167
      WBVar00193468
      WBVar00193469
      WBVar02147450
      WBVar00193470
      WBVar00193471
      WBVar00193472
      WBVar00193473
      WBVar00193474
      WBVar00251104
      WBVar00193475
      WBVar00193476
      WBVar00193477
      WBVar00193478
      WBVar01688493
      WBVar01454971
      WBVar00193479
      WBVar01688494
      WBVar01454972
      WBVar01688495
      WBVar01454973
      WBVar00193480
      WBVar02021472
      WBVar01688496
      WBVar00193481
      WBVar00193482
      WBVar02021473
      WBVar01688497
      WBVar00193483
      WBVar01688498
      WBVar00193484
      WBVar00193485
      WBVar00193486
      WBVar02042353
      WBVar02042354
      WBVar00093161
      WBVar00193487
      WBVar02042355
      WBVar02042356
      WBVar00439654
      WBVar00439655
      WBVar00439656
      WBVar00439657
      WBVar00439658
      WBVar01731584
      WBVar01731585
      WBVar00439659
      WBVar01731586
      WBVar00439660
      WBVar01731587
      WBVar00439661
      WBVar01731588
      WBVar00439662
      WBVar01731589
      WBVar00439663
      WBVar00439664
      WBVar01731590
      WBVar01731591
      WBVar00439665
      WBVar00439666
      WBVar00439667
      WBVar00439668
      WBVar02134963
      WBVar01821333
      WBVar01821334
      WBVar01499492
      WBVar01821335
      WBVar01499493
      WBVar01500245
    RNASeq_FPKM (74)
    GO_annotation (22)
    Contained_in_operon: CEOP4552
    Ortholog (42)
    Paralog (12)
    Structured_description: Concise_description: The pik-1 gene encodes a pelle/IRAK kinase homolog that may be involved in apoptosis. Paper_evidence: WBPaper00004589
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in cellular response to lipopolysaccharide and signal transduction. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Expressed in RMGL; RMGR; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of musculoskeletal system (multiple); diffuse scleroderma; and melioidosis. Is an ortholog of human IRAK1 (interleukin 1 receptor associated kinase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17967)
      DOID:9008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:7147 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:8893 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:399 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17020)
      DOID:2841 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17020)
      DOID:1580 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:1749 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:5052 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17020)
  Molecular_info: Corresponding_CDS: K09B11.1a
      K09B11.1b
    Corresponding_CDS_history: K09B11.1:wp80
    Corresponding_transcript: K09B11.1c
      K09B11.1a.1
      K09B11.1a.2
      K09B11.1b.1
    Other_sequence (35)
    Associated_feature: WBsf998403
      WBsf998404
  Experimental_info: RNAi_result: WBRNAi00112978 Inferred_automatically: RNAi_primary
      WBRNAi00016868 Inferred_automatically: RNAi_primary
      WBRNAi00113208 Inferred_automatically: RNAi_primary
      WBRNAi00034179 Inferred_automatically: RNAi_primary
      WBRNAi00075962 Inferred_automatically: RNAi_primary
      WBRNAi00050370 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr13217
      Expr1010645
      Expr1031931
      Expr1154076
      Expr2014927
      Expr2033162
    Drives_construct: WBCnstr00038894
    Construct_product: WBCnstr00038894
    Microarray_results (22)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_depleted
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:AIN_parent
      WBPaper00061340:AMso_parent
      WBPaper00061340:K_Kprime
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061527:176662_at-Y53F4B.16
      WBPaper00061613:human-amyloid-beta_upregulated
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062146:MOG-7-degron_1h_regulated
      WBPaper00062146:MOG-7-degron_2h_regulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00036286:Pattern_H
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (320)
    WBProcess: WBbiopr:00000039
  Map_info: Map: IV Position: 9.21545 Error: 0.07179
    Positive: Positive_clone: K09B11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4585
        4914
    Pseudo_map_position
  Reference (14)
  Remark: Sequence given as K09B11 BUT subsequence not given [sdm]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene