WormBase Tree Display for Gene: WBGene00001964
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WBGene00001964 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C17C3 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | hlh-25 | Person_evidence | WBPerson346 | |||||
Sequence_name | C17C3.7 | ||||||||
Molecular_name | C17C3.7 | ||||||||
C17C3.7.1 | |||||||||
CE42919 | |||||||||
Other_name | CELE_C17C3.7 | Accession_evidence | NDB | BX284602 | |||||
Public_name | hlh-25 | ||||||||
DB_info | Database | AceView | gene | 2F825 | |||||
WormQTL | gene | WBGene00001964 | |||||||
WormFlux | gene | WBGene00001964 | |||||||
NDB | locus_tag | CELE_C17C3.7 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00001964|UniProtKB=Q18054 | |||||||
family | PTHR10985 | ||||||||
NCBI | gene | 182717 | |||||||
RefSeq | protein | NM_062662.3 | |||||||
SwissProt | UniProtAcc | Q18054 | |||||||
TREEFAM | TREEFAM_ID | TF322171 | |||||||
UniProt_GCRP | UniProtAcc | Q18054 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | hlh | ||||||||
Allele | WBVar00092915 | Inferred_automatically | From strain object: VC1220 | ||||||
WBVar01499702 | |||||||||
WBVar01498435 | |||||||||
WBVar01603876 | |||||||||
WBVar01898525 | |||||||||
WBVar02084798 | |||||||||
WBVar02002685 | |||||||||
WBVar02017927 | |||||||||
WBVar00249480 | |||||||||
WBVar01306081 | |||||||||
WBVar01306082 | |||||||||
WBVar01498575 | |||||||||
Strain | WBStrain00036426 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (14) | |||||||||
Ortholog (22) | |||||||||
Paralog | WBGene00003008 | Caenorhabditis elegans | From_analysis | Panther | |||||
WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
WormBase-Compara | |||||||||
WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
WormBase-Compara | |||||||||
WBGene00001966 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00001965 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-deficient genetic backgrounds; HLH-25 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-25 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage; ectopic HLH-25 can induce body muscle development in skn-1(RNAi);pal-1(RNAi) embryos that would otherwise lack muscle; HLH-25 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00006395 | |||||
WBPaper00025235 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 18 Apr 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including MSpa; anal depressor muscle; body wall musculature; intestinal cell; and neurons. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed (2) | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C17C3.7 | |||||||
Corresponding_CDS_history | C17C3.7:wp193 | ||||||||
Corresponding_transcript | C17C3.7.1 | ||||||||
Associated_feature | WBsf978550 | ||||||||
Transcription_factor | WBTranscriptionFactor000072 | ||||||||
Experimental_info | RNAi_result | WBRNAi00010905 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00010899 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084010 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00040773 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00024579 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00040785 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027179 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr3495 | ||||||||
Expr8067 | |||||||||
Expr12501 | |||||||||
Expr1144824 | |||||||||
Expr2012500 | |||||||||
Expr2030739 | |||||||||
Drives_construct | WBCnstr00005197 | ||||||||
WBCnstr00011427 | |||||||||
WBCnstr00021040 | |||||||||
WBCnstr00021041 | |||||||||
WBCnstr00036556 | |||||||||
Construct_product | WBCnstr00005197 | ||||||||
WBCnstr00021041 | |||||||||
WBCnstr00036556 | |||||||||
Regulate_expr_cluster | WBPaper00048624:hlh-25(ok1710)_downregulated | ||||||||
WBPaper00048624:hlh-25(ok1710)_upregulated | |||||||||
Microarray_results (15) | |||||||||
Expression_cluster | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray | ||||||||
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated | |||||||||
WBPaper00055386:daf-2(e1370)_downregulated | |||||||||
WBPaper00058598:sin-3(tm1276)_upregulated | |||||||||
WBPaper00060014:set-2(tm1630)_upregulated | |||||||||
WBPaper00061040:eat-2(ad1116)_upregulated | |||||||||
WBPaper00061203:sin-3(tm1276)_downregulated | |||||||||
WBPaper00061203:spr-1(ok2144)_downregulated | |||||||||
WBPaper00061340:ADEsh | |||||||||
WBPaper00061424:Diet_MYb120_downregulated | |||||||||
WBPaper00061527:sre-33-ZK1025.1_8337 | |||||||||
WBPaper00061853:osm-3(dh441)_upregulated | |||||||||
WBPaper00062159:hda-2(ok1479)_downregulated | |||||||||
WBPaper00062325:muscle_enriched_coding-RNA | |||||||||
WBPaper00065993:glp-1(e2141)_downregulated | |||||||||
WBPaper00066232:ash-2(RNAi)_upregulated_WT | |||||||||
cgc4489_group_21 | |||||||||
WBPaper00025032:cluster_134 | |||||||||
WBPaper00038427:lin-54_embryo_changed | |||||||||
WBPaper00042067:Cu2+_upregulated_WT | |||||||||
WBPaper00045673:colistin_downregulated | |||||||||
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated | |||||||||
WBPaper00048989:N2_allantoin_upregulated | |||||||||
WBPaper00056330:mrps-5(RNAi)_downregulated | |||||||||
[cgc5767]:cluster_25 | |||||||||
[cgc5767]:expression_class_E | |||||||||
[cgc5767]:expression_class_ET | |||||||||
[cgc5767]:expression_class_ET_max(41_min) | |||||||||
[cgc5767]:expression_class_E_pi(23_min) | |||||||||
[cgc5767]:expression_class_SE | |||||||||
[cgc5767]:expression_class_SET | |||||||||
[cgc5767]:expression_class_SE_pi(23_min) | |||||||||
Interaction (59) | |||||||||
Map_info | Map | II | Position | -1.19086 | Error | 0.002255 | |||
Positive | Positive_clone | C17C3 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00025235 | ||||||||
WBPaper00026325 | |||||||||
WBPaper00027287 | |||||||||
WBPaper00027309 | |||||||||
WBPaper00029033 | |||||||||
WBPaper00034761 | |||||||||
WBPaper00043858 | |||||||||
WBPaper00048624 | |||||||||
WBPaper00061738 | |||||||||
WBPaper00062117 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |