WormBase Tree Display for Gene: WBGene00003995
expand all nodes | collapse all nodes | view schema
| WBGene00003995 | SMap | S_parent | Sequence | K08E7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-1 | Person_evidence | WBPerson490 | |||||
| Sequence_name | K08E7.9 | ||||||||
| Molecular_name | K08E7.9 | ||||||||
| K08E7.9.1 | |||||||||
| CE11932 | |||||||||
| Other_name | cepgpA | Accession_evidence | EMBL | X65054 | |||||
| CELE_K08E7.9 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | pgp-1 | ||||||||
| DB_info | Database | AceView | gene | 4N356 | |||||
| WormQTL | gene | WBGene00003995 | |||||||
| WormFlux | gene | WBGene00003995 | |||||||
| NDB | locus_tag | CELE_K08E7.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003995|UniProtKB=P34712 | |||||||
| family | PTHR24221 | ||||||||
| NCBI | gene | 178215 | |||||||
| RefSeq | protein | NM_070012.6 | |||||||
| KEGG | KEGG_id | 7.6.2.2 | |||||||
| NemaPath | KEGG_id | 7.6.2.2 | |||||||
| SwissProt | UniProtAcc | P34712 | |||||||
| UniProt_GCRP | UniProtAcc | P34712 | |||||||
| OMIM | gene | 171050 | |||||||
| 171060 | |||||||||
| 603201 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele | WBVar00239171 | ||||||||
| WBVar00239170 | |||||||||
| WBVar00949365 | |||||||||
| WBVar00949366 | |||||||||
| WBVar00949367 | |||||||||
| WBVar00949368 | |||||||||
| WBVar00949369 | |||||||||
| WBVar00949370 | |||||||||
| WBVar00949371 | |||||||||
| WBVar00949372 | |||||||||
| WBVar00949373 | |||||||||
| WBVar00949374 | |||||||||
| WBVar00949375 | |||||||||
| WBVar01500079 | |||||||||
| WBVar00949376 | |||||||||
| WBVar01954109 | |||||||||
| WBVar00949377 | |||||||||
| WBVar00949378 | |||||||||
| WBVar00949379 | |||||||||
| WBVar00949380 | |||||||||
| WBVar00949381 | |||||||||
| WBVar00949382 | |||||||||
| WBVar01498982 | |||||||||
| WBVar00949383 | |||||||||
| WBVar00949384 | |||||||||
| WBVar00949385 | |||||||||
| WBVar00949386 | |||||||||
| WBVar00949387 | |||||||||
| WBVar00949388 | |||||||||
| WBVar00949389 | |||||||||
| WBVar00949390 | |||||||||
| WBVar00949391 | |||||||||
| WBVar00949392 | |||||||||
| WBVar00949393 | |||||||||
| WBVar00949394 | |||||||||
| WBVar01494761 | |||||||||
| WBVar00949395 | |||||||||
| WBVar00949396 | |||||||||
| WBVar01498996 | |||||||||
| WBVar00270807 | |||||||||
| WBVar01499925 | |||||||||
| WBVar00239159 | |||||||||
| WBVar02134851 | |||||||||
| WBVar02151113 | |||||||||
| WBVar01482472 | |||||||||
| WBVar00438113 | |||||||||
| WBVar00438114 | |||||||||
| WBVar01482473 | |||||||||
| WBVar00438115 | |||||||||
| WBVar00438116 | |||||||||
| WBVar00438117 | |||||||||
| WBVar00438118 | |||||||||
| WBVar00438119 | |||||||||
| WBVar00438120 | |||||||||
| WBVar00438121 | |||||||||
| WBVar00438122 | |||||||||
| WBVar01570016 | |||||||||
| WBVar01570017 | |||||||||
| WBVar00438123 | |||||||||
| WBVar00438124 | |||||||||
| WBVar01570018 | |||||||||
| WBVar00438125 | |||||||||
| WBVar00438126 | |||||||||
| WBVar00438127 | |||||||||
| WBVar00438128 | |||||||||
| WBVar00438129 | |||||||||
| WBVar00438130 | |||||||||
| WBVar00438131 | |||||||||
| WBVar00438132 | |||||||||
| WBVar01657309 | |||||||||
| WBVar01731359 | |||||||||
| WBVar01731360 | |||||||||
| WBVar01731361 | |||||||||
| WBVar01859813 | |||||||||
| WBVar01859814 | |||||||||
| WBVar01859815 | |||||||||
| WBVar01859816 | |||||||||
| WBVar01859817 | |||||||||
| WBVar01859818 | |||||||||
| WBVar01859819 | |||||||||
| WBVar01859820 | |||||||||
| WBVar01795875 | |||||||||
| WBVar01859821 | |||||||||
| WBVar01859822 | |||||||||
| WBVar01795876 | |||||||||
| WBVar02059431 | |||||||||
| WBVar01859823 | |||||||||
| WBVar01795877 | |||||||||
| WBVar02059432 | |||||||||
| WBVar02059433 | |||||||||
| WBVar01859824 | |||||||||
| WBVar02059434 | |||||||||
| WBVar00192571 | |||||||||
| WBVar00192572 | |||||||||
| WBVar00192573 | |||||||||
| WBVar01499492 | |||||||||
| WBVar00949346 | |||||||||
| WBVar00949347 | |||||||||
| WBVar00949348 | |||||||||
| WBVar00949349 | |||||||||
| WBVar00949350 | |||||||||
| WBVar00949351 | |||||||||
| WBVar00949352 | |||||||||
| WBVar00949353 | |||||||||
| WBVar00949354 | |||||||||
| WBVar00949355 | |||||||||
| WBVar00949356 | |||||||||
| WBVar00949357 | |||||||||
| WBVar00949358 | |||||||||
| WBVar01500245 | |||||||||
| WBVar00069799 | |||||||||
| WBVar00949359 | |||||||||
| WBVar00949360 | |||||||||
| WBVar00949361 | |||||||||
| WBVar00245546 | |||||||||
| WBVar00949362 | |||||||||
| WBVar00949363 | |||||||||
| WBVar00949364 | |||||||||
| Legacy_information | [C.elegansII] pk17 : deletion derived from pk28tci, no apparent drug sensitivity or other phenotype. Cloned: encodes 1321 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins.Transcripts relatively low, peak early;pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-1 detected in gut apical membrane. [Broeks et al. 1995; NL] | ||||||||
| Strain | WBStrain00028887 | ||||||||
| WBStrain00028889 | |||||||||
| WBStrain00028891 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (64) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells. | Paper_evidence | WBPaper00002180 | |||||
| WBPaper00003366 | |||||||||
| WBPaper00003925 | |||||||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to other organism; response to metal ion; and response to nematicide. Located in apical plasma membrane. Expressed in intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info (4) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00070104 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00016820 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085165 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050311 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085169 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091137 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085175 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr710 | ||||||||
| Expr1546 | |||||||||
| Expr1548 | |||||||||
| Expr3339 | |||||||||
| Expr12394 | |||||||||
| Expr1021232 | |||||||||
| Expr1031911 | |||||||||
| Expr1154012 | |||||||||
| Expr2014868 | |||||||||
| Expr2033103 | |||||||||
| Drives_construct | WBCnstr00010330 | ||||||||
| WBCnstr00011335 | |||||||||
| WBCnstr00012502 | |||||||||
| WBCnstr00017594 | |||||||||
| WBCnstr00017595 | |||||||||
| WBCnstr00019886 | |||||||||
| WBCnstr00035755 | |||||||||
| Construct_product | WBCnstr00007868 | ||||||||
| WBCnstr00007870 | |||||||||
| WBCnstr00007871 | |||||||||
| WBCnstr00019886 | |||||||||
| WBCnstr00035755 | |||||||||
| Antibody | WBAntibody00000095 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (314) | |||||||||
| Interaction (63) | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| Map_info | Map | IV | Position | 6.0845 | Error | 0.005937 | |||
| Positive | Positive_clone | K08E7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| PB#CPG10 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (45) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
