WormBase Tree Display for Gene: WBGene00017066
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| WBGene00017066 | SMap | S_parent | Sequence | D2092 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | maco-1 | Paper_evidence | WBPaper00038258 | |||||
| Person_evidence | WBPerson724 | ||||||||
| Sequence_name | D2092.5 | ||||||||
| Molecular_name | D2092.5 | ||||||||
| D2092.5.1 | |||||||||
| CE45670 | |||||||||
| Other_name | CELE_D2092.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | maco-1 | ||||||||
| DB_info | Database | AceView | gene | 1H170 | |||||
| WormQTL | gene | WBGene00017066 | |||||||
| WormFlux | gene | WBGene00017066 | |||||||
| NDB | locus_tag | CELE_D2092.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00017066|UniProtKB=P91193 | |||||||
| family | PTHR13289 | ||||||||
| NCBI | gene | 183963 | |||||||
| RefSeq | protein | NM_059501.7 | |||||||
| SwissProt | UniProtAcc | P91193 | |||||||
| TREEFAM | TREEFAM_ID | TF324023 | |||||||
| UniProt_GCRP | UniProtAcc | P91193 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 06 Apr 2011 14:40:30 | WBPerson2970 | Name_change | CGC_name | maco-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | maco | ||||||||
| Allele | WBVar00251729 | ||||||||
| WBVar00154074 | |||||||||
| WBVar00154075 | |||||||||
| WBVar00597666 | |||||||||
| WBVar00597667 | |||||||||
| WBVar00094238 | |||||||||
| WBVar00531926 | |||||||||
| WBVar00531927 | |||||||||
| WBVar00531928 | |||||||||
| WBVar00644774 | |||||||||
| WBVar00644775 | |||||||||
| WBVar00644776 | |||||||||
| WBVar00644777 | |||||||||
| WBVar00644778 | |||||||||
| WBVar00644779 | |||||||||
| WBVar00644780 | |||||||||
| WBVar00644781 | |||||||||
| WBVar00644782 | |||||||||
| WBVar00644783 | |||||||||
| WBVar00644784 | |||||||||
| WBVar00644785 | |||||||||
| WBVar00644786 | |||||||||
| WBVar00644787 | |||||||||
| WBVar00644788 | |||||||||
| WBVar00644789 | |||||||||
| WBVar00644790 | |||||||||
| WBVar00644791 | |||||||||
| WBVar00644792 | |||||||||
| WBVar02127655 | |||||||||
| WBVar00644793 | |||||||||
| WBVar00644794 | |||||||||
| WBVar02127656 | |||||||||
| WBVar00644795 | |||||||||
| WBVar02127657 | |||||||||
| WBVar00644796 | |||||||||
| WBVar00644797 | |||||||||
| WBVar00644798 | |||||||||
| WBVar00644799 | |||||||||
| WBVar00644800 | |||||||||
| WBVar01431931 | |||||||||
| WBVar00644801 | |||||||||
| WBVar00644802 | |||||||||
| WBVar00644803 | |||||||||
| WBVar00644804 | |||||||||
| WBVar00644805 | |||||||||
| WBVar00644806 | |||||||||
| WBVar00644807 | |||||||||
| WBVar00644808 | |||||||||
| WBVar00644809 | |||||||||
| WBVar00644810 | |||||||||
| WBVar02151128 | |||||||||
| WBVar00644811 | |||||||||
| WBVar00644812 | |||||||||
| WBVar00644813 | |||||||||
| WBVar00644814 | |||||||||
| WBVar00644815 | |||||||||
| WBVar00644816 | |||||||||
| WBVar00276210 | |||||||||
| WBVar00251442 | |||||||||
| WBVar01499786 | |||||||||
| WBVar01499054 | |||||||||
| WBVar02039695 | |||||||||
| WBVar02039696 | |||||||||
| WBVar00336577 | |||||||||
| WBVar01417153 | |||||||||
| WBVar01283296 | |||||||||
| WBVar00336578 | |||||||||
| WBVar00336579 | |||||||||
| WBVar01283297 | |||||||||
| WBVar00336580 | |||||||||
| WBVar00336581 | |||||||||
| WBVar00336582 | |||||||||
| WBVar00336583 | |||||||||
| WBVar00336584 | |||||||||
| WBVar00336585 | |||||||||
| WBVar01499828 | |||||||||
| WBVar01909692 | |||||||||
| WBVar02145415 | |||||||||
| WBVar01498959 | |||||||||
| WBVar02072826 | |||||||||
| Strain | WBStrain00033005 | ||||||||
| WBStrain00022012 | |||||||||
| WBStrain00022013 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | maco-1 encodes a novel protein with five transmembrane domains in the N-terminus and four coiled coil domains in the C-terminus; maco-1 is functionally conserved across species and is orthologous to human macoilin (OMIM:601301); macoilin is involved in assembly or traffic of ion channels or ion channel regulators; MACO-1 is not required for development but for appropriate regulation of neuronal activity; both transmembrane domains and coiled coil domains are required for appropriate function of MACO-1; proper function of MACO-1 is necessary for normal thermotaxis in many neurons; mutations in C. elegans macoilin disrupt aggregation and are associated with multiple behavioral defects; MACO-1 is localized to the rough ER of neurons; MACO-1 is also restricted to neuronal cell bodies at embryonic developmental stages. | Paper_evidence | WBPaper00038258 | |||||
| WBPaper00038428 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 15 Jul 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable microtubule binding activity. Involved in chemotaxis; neuronal signal transduction; and thermotaxis. Located in neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Expressed in epithelial cell; muscle cell; and nervous system. Is an ortholog of human MACO1 (macoilin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | D2092.5 | |||||||
| Corresponding_CDS_history | D2092.5:wp154 | ||||||||
| D2092.5:wp221 | |||||||||
| Corresponding_transcript | D2092.5.1 | ||||||||
| Other_sequence | CRC06233_1 | ||||||||
| Oden_isotig19062 | |||||||||
| CR10623 | |||||||||
| CJC09089_1 | |||||||||
| Associated_feature | WBsf664350 | ||||||||
| WBsf664351 | |||||||||
| WBsf717512 | |||||||||
| WBsf983965 | |||||||||
| WBsf983966 | |||||||||
| WBsf983967 | |||||||||
| WBsf983968 | |||||||||
| WBsf1009970 | |||||||||
| WBsf1009971 | |||||||||
| WBsf1009972 | |||||||||
| WBsf219609 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00043519 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00043518 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007973 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003295 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116562 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00013794 | ||||||||
| WBCnstr00013887 | |||||||||
| WBCnstr00013888 | |||||||||
| WBCnstr00018769 | |||||||||
| WBCnstr00027595 | |||||||||
| Construct_product | WBCnstr00013794 | ||||||||
| WBCnstr00013888 | |||||||||
| WBCnstr00021857 | |||||||||
| WBCnstr00027595 | |||||||||
| Antibody | WBAntibody00002220 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction | WBInteraction000253192 | ||||||||
| WBInteraction000303978 | |||||||||
| WBInteraction000323592 | |||||||||
| WBInteraction000443269 | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| Map_info | Map | I | Position | 1.23755 | Error | 0.004358 | |||
| Positive | Positive_clone | D2092 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
