WormBase Tree Display for Disease_model_annotation: WBDOannot00001289
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| WBDOannot00001289 | Disease_term | DOID:1596 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Variation | WBVar00367814 | |
| Asserted_gene | WBGene00017437 | ||
| Association_type | is_implicated_in | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00062210 | ||
| Disease_model_description | In mammalian models of chronic stress, brain levels of GPM6A, a protein involved in neuronal morphology, are altered. In C. elegans, worms mutant for nmgp-1 exhibit increased recovery time from the stress-resistant dauer stage, altered SDS chemosensation and reduced egg-laying rate resulting in egg retention. nmgp-1 mutants may serve as model to study stress related diseases such as depression and other neurospychiatric disorders. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 20 Jul 2022 00:00:00 |
