WormBase Tree Display for Analysis: Microarray_Study.WBPaper00005475.ce.mr
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Microarray_Study.WBPaper00005475.ce.mr | DB_info | Database | GEO | GSE4005 |
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Title | Aging time course | |||
Description | Transcriptional Profile of Aging in C. elegans Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1% of the genome). Expression of heat shock proteins decreases, while expression of certain transposases increases in older worms, and these findings are consistent with a higher mortality risk due to a failure in homeostenosis and destabilization of the genome in older animals. Finally, a specific subset of genes is coordinately altered both during chronological aging and in the transition from the reproductive form to the dauer, demonstrating a mechanistic overlap in aging between these two processes. Groups of assays that are related as part of a time series. Age: Age of organism Keywords: time_series_design | |||
Category | aging | |||
Microarray_experiment | [cgc5475]:day12-14 | |||
[cgc5475]:day16-19 | ||||
[cgc5475]:day3 | ||||
[cgc5475]:day4 | ||||
[cgc5475]:day6-7 | ||||
[cgc5475]:day9-11 | ||||
Species_in_analysis | Caenorhabditis elegans | |||
Reference | WBPaper00005475 |