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WormBase Tree Display for Variation: WBVar02149951

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Name Class

WBVar02149951EvidencePaper_evidenceWBPaper00057072
NamePublic_nameju190
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryCZ
StatusLive
AffectsGeneWBGene00001325
DescriptionPhenotypeWBPhenotype:0000354Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
Remark"We also made double mutants of eor-2(ju190) and ced-3(n717), which blocks apoptosis, and found that eor-2(ju190); ced-3(n717) double mutants showed absence of Punc-25GFP expression in RMED/V, similar to eor-2(ju190) single mutants, indicating that in eor-2(ju190) and eor-1(ju198) animals, the RMED and RMEV cells are alive, but that their differentiated traits are likely altered." "We found that in eor-2(ju190) animals, Pavr-15GFP was not expressed in RMED/V (Figure 1C), the GFP intensity from Plim-4GFP transgene was greatly reduced, but not abolished, in all expressing cells (Figure 1D). These data show that eor-2(ju190) alters multiple differentiated aspects of RMED/V neurons."Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
ImageWBPicture0000014912Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005027PATO:0000460Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
WBbt:0005021PATO:0000460Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
WBPhenotype:0000411Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
Remark"eor-2(ju190) animals also displayed mild Unc, low penetrant Egl and rod-like lethality."Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
ImageWBPicture0000014912Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
WBPhenotype:0000640Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
Remark"eor-2(ju190) animals also displayed mild Unc, low penetrant Egl and rod-like lethality."Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
ImageWBPicture0000014912Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
WBPhenotype:0000643Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
Remark"eor-2(ju190) animals also displayed mild Unc, low penetrant Egl and rod-like lethality."Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
ImageWBPicture0000014912Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
WBPhenotype:0001376Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
Remark"The absence of Punc-25GFP expression was seen in all larval stages and adults, was more frequent in RMED than in RMEV cells."Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
ImageWBPicture0000014912Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005027PATO:0000460Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
WBbt:0005021PATO:0000460Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0002402Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
Remark"In both eor-2(ju190) and eor-1(ju198) mutants, the RMED and RMEV cells were found in their normal locations (Figure 1B). 'Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
ImageWBPicture0000014912Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005027PATO:0000460Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
WBbt:0005021PATO:0000460Paper_evidenceWBPaper00057073
Curator_confirmedWBPerson712
ReferenceWBPaper00057072
WBPaper00057073
RemarkCreated in the nameserver by Karen Yook
WBPaper00057072 a C to T nucleotide transition that results in an Opal stop at Arg721, in the conserved C-terminal domain (Figure 1A). Therefore, the RMED V defects in ju190 arise from a complete loss of EOR-2 function.
MethodAllele