WormBase Tree Display for Variation: WBVar02149951
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WBVar02149951 | Evidence | Paper_evidence | WBPaper00057072 | ||||||
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Name | Public_name | ju190 | |||||||
Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Laboratory | CZ | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00001325 | |||||||
Description | Phenotype | WBPhenotype:0000354 | Paper_evidence | WBPaper00057073 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | "We also made double mutants of eor-2(ju190) and ced-3(n717), which blocks apoptosis, and found that eor-2(ju190); ced-3(n717) double mutants showed absence of Punc-25GFP expression in RMED/V, similar to eor-2(ju190) single mutants, indicating that in eor-2(ju190) and eor-1(ju198) animals, the RMED and RMEV cells are alive, but that their differentiated traits are likely altered." "We found that in eor-2(ju190) animals, Pavr-15GFP was not expressed in RMED/V (Figure 1C), the GFP intensity from Plim-4GFP transgene was greatly reduced, but not abolished, in all expressing cells (Figure 1D). These data show that eor-2(ju190) alters multiple differentiated aspects of RMED/V neurons." | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Image | WBPicture0000014912 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005027 | PATO:0000460 | Paper_evidence | WBPaper00057073 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005021 | PATO:0000460 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000411 | Paper_evidence | WBPaper00057073 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | "eor-2(ju190) animals also displayed mild Unc, low penetrant Egl and rod-like lethality." | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Image | WBPicture0000014912 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000640 | Paper_evidence | WBPaper00057073 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | "eor-2(ju190) animals also displayed mild Unc, low penetrant Egl and rod-like lethality." | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Image | WBPicture0000014912 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Penetrance | Low | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000643 | Paper_evidence | WBPaper00057073 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | "eor-2(ju190) animals also displayed mild Unc, low penetrant Egl and rod-like lethality." | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Image | WBPicture0000014912 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001376 | Paper_evidence | WBPaper00057073 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | "The absence of Punc-25GFP expression was seen in all larval stages and adults, was more frequent in RMED than in RMEV cells." | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Image | WBPicture0000014912 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005027 | PATO:0000460 | Paper_evidence | WBPaper00057073 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005021 | PATO:0000460 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed | WBPhenotype:0002402 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | "In both eor-2(ju190) and eor-1(ju198) mutants, the RMED and RMEV cells were found in their normal locations (Figure 1B). ' | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Image | WBPicture0000014912 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005027 | PATO:0000460 | Paper_evidence | WBPaper00057073 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005021 | PATO:0000460 | Paper_evidence | WBPaper00057073 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00057072 | ||||||||
WBPaper00057073 | |||||||||
Remark | Created in the nameserver by Karen Yook | ||||||||
WBPaper00057072 a C to T nucleotide transition that results in an Opal stop at Arg721, in the conserved C-terminal domain (Figure 1A). Therefore, the RMED V defects in ju190 arise from a complete loss of EOR-2 function. | |||||||||
Method | Allele |