WormBase Tree Display for Variation: WBVar00603960

WBVar00603960 Evidence: Paper_evidence: WBPaper00040694
  Name: Public_name: n2657
    Other_name: F58E10.1b.1:c.620delinsA
      CE40076:p.Trp207Ter
      CE30677:p.Trp192Ter
      F58E10.1a.1:c.575delinsA
    HGVSg: CHROMOSOME_V:g.13997887delinsT
  Sequence_details: SMap: S_parent: Sequence: F58E10
    Flanking_sequences: ctgtcaaatcagcatcatttcgaatagttt gaaggatctcaaccatcttgggatgatttt
    Mapping_target: F58E10
    Type_of_mutation: Substitution: gg rr Paper_evidence: WBPaper00040694
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00027272
      WBStrain00047712
      WBStrain00047714
      WBStrain00047715
      WBStrain00055671
      WBStrain00055672
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00305465
      WBGene00010259
    Transcript: F58E10.8
      F58E10.1a.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F58E10.1a.1:c.575delinsA
        HGVSp: CE30677:p.Trp192Ter
        cDNA_position: 726-727
        CDS_position: 575-576
        Protein_position: 192
        Exon_number: 6/15
        Codon_change: tGG/tAG
        Amino_acid_change: W/*
      F58E10.1b.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F58E10.1b.1:c.620delinsA
        HGVSp: CE40076:p.Trp207Ter
        cDNA_position: 620-621
        CDS_position: 620-621
        Protein_position: 207
        Exon_number: 5/14
        Codon_change: tGG/tAG
        Amino_acid_change: W/*
    Interactor: WBInteraction000517474
      WBInteraction000517475
  Genetics: Interpolated_map_position: V 5.89298
  Description: Phenotype: WBPhenotype:0000017 Paper_evidence: WBPaper00040694
          WBPaper00045008
        Curator_confirmed: WBPerson712
          WBPerson298
        Remark: Animals homozygous for n2657 were resistant to the paralytic effects of aldicarb. Paper_evidence: WBPaper00040694
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003650 Paper_evidence: WBPaper00040694
              Curator_confirmed: WBPerson712
      WBPhenotype:0000651 Paper_evidence: WBPaper00045008
        Curator_confirmed: WBPerson298
      WBPhenotype:0000905 Paper_evidence: WBPaper00045008
        Curator_confirmed: WBPerson298
        Remark: GABA motor neuron axons lack mitochondria. Paper_evidence: WBPaper00045008
            Curator_confirmed: WBPerson298
        EQ_annotations: Anatomy_term: WBbt:0005190 PATO:0000460 Paper_evidence: WBPaper00045008
                Curator_confirmed: WBPerson298
      WBPhenotype:0002379 Paper_evidence: WBPaper00045008
        Curator_confirmed: WBPerson298
        Remark: Mitochondria mislocalization phenotype. Paper_evidence: WBPaper00045008
            Curator_confirmed: WBPerson298
      WBPhenotype:0002380 Paper_evidence: WBPaper00045008
        Curator_confirmed: WBPerson298
        Remark: Animals exhibit enhanced degeneration of severed GABA motor neuron axons (DD and VD), ACh motor neuron axons (DB), and ALA axons Paper_evidence: WBPaper00045008
            Curator_confirmed: WBPerson298
        EQ_annotations: Anatomy_term: WBbt:0005270 PATO:0000460 Paper_evidence: WBPaper00045008
                Curator_confirmed: WBPerson298
            WBbt:0005303 PATO:0000460 Paper_evidence: WBPaper00045008
                Curator_confirmed: WBPerson298
            WBbt:0005274 PATO:0000460 Paper_evidence: WBPaper00045008
                Curator_confirmed: WBPerson298
            WBbt:0003955 PATO:0000460 Paper_evidence: WBPaper00045008
                Curator_confirmed: WBPerson298
  Reference: WBPaper00040694
    WBPaper00045008
  Method: Substitution_allele