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WormBase Tree Display for Variation: WBVar00600743

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Name Class

WBVar00600743EvidencePaper_evidenceWBPaper00038069
NamePublic_namewk156
Other_nameF08C6.1c.1:c.1090G>A
CE47865:p.Gly364Ser
CE48012:p.Gly364Ser
F08C6.1a.1:c.1090G>A
HGVSgCHROMOSOME_X:g.7590093G>A
Sequence_detailsSMapS_parentSequenceF08C6
Flanking_sequencesacctctgcttttatcgggacacacgaactcgccataggtttacagtaacataaagaagtt
Mapping_targetF08C6
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00038069
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005159
LaboratoryLT
StatusLive
AffectsGeneWBGene00000083
TranscriptF08C6.1c.1 (12)
F08C6.1a.1 (12)
Interactor (11)
GeneticsInterpolated_map_positionX-1.47956
DescriptionPhenotypeWBPhenotype:0000229Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
RemarkSemi-small. Fails to complement tm975 for body size. Newly hatched adt-2 mutant larvae have the same body length as control animals. adt-2 mutant worms grow more slowly after 24 hours resulting in adult worms with about a 20% reduced body length when compared to wild type.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0000583Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0000676Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
Remarkadt-2 mutant worms grow more slowly after 24 hours.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0001017Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
RemarkAdult adt-2 mutants show a significant decrease in body length between 96 and 120 h, whereas wild-type animals continue to grow larger during adulthood.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0001171Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
Remarkadt-2(wk156)mutants have significantly reduced lifespans compared to wild type, with a median survival of 10 and 8 days from adulthood, respectively, compared with 16 days for wild type.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0001517Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
RemarkThe annuli are constricted. In adt-2(tm975/wk156) transheterozygous animals, patches of disorganized annuli are observed as well as structural defects in the alae. The defects are discontinuous alae and alae with two or four ridges as compared to three ridges in the wild-type worms.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0001727Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
RemarkMutants show a significantly increased body width compared to N2 wild-type controls grown concurrently under the same conditions.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0002025Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
RemarkThe perimeters of individual seam cells are reduced significantly compared to wild-type animals.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000171Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
Remarkadt-2(wk156)mutants have normal numbers of seam cells, intestinal cells, and hypodermal nuclei compared with wild-type controls.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0000709Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
RemarkThe length of the pharynx is not affected.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
WBPhenotype:0000961Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
RemarkNo significant disruption of the COL-19::GFP organization is observed.Paper_evidenceWBPaper00038069
Curator_confirmedWBPerson712
ReferenceWBPaper00038069
MethodSubstitution_allele