WormBase Tree Display for Variation: WBVar00296598

WBVar00296598 Evidence: Paper_evidence: WBPaper00036073
  Name: Public_name: qm169
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: MQ
    Status: Live
  Affects: Gene: WBGene00202510
    Interactor: WBInteraction000517498
  Description: Phenotype: WBPhenotype:0000042 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00036073
                Curator_confirmed: WBPerson712
      WBPhenotype:0000061 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
      WBPhenotype:0000119 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Although SOD-1 levels were unchanged from wild-type levels, SOD-2 levels appeared to be increased. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000154 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
      WBPhenotype:0000207 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: slow defecation Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000641 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Clk mutants had a longer period of mobility than wild-type worms. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000674 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000022 PATO:0000460 Paper_evidence: WBPaper00036073
                Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0001621 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Worms are more sensitive to oxidative stress than wild-type worms. | At 0.2 mM paraquat, worms showed early developmental arrest in response to oxidative stress. | Worms all showed developmental deficits compared to N2 worms. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004938 Paper_evidence: WBPaper00036073
              Curator_confirmed: WBPerson712
            WBMol:00002747 Paper_evidence: WBPaper00036073
              Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0002163 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Measurement of whole-worm oxygen consumption in day 1 adult worms revealed that Clk mutants showed decreased oxygen consumption compared to wild-type worms. | Unlike control animals, the Clk mutants do not show any decrease in oxygen consumption from day 1 to day 7. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0001574 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: ATP levels are normal, with a trend towards and increase, despite decreased mitochondrial function. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
  Reference: WBPaper00036073
  Method: Allele