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WormBase Tree Display for Variation: WBVar00296476

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Name Class

WBVar00296476EvidencePaper_evidenceWBPaper00036467
NamePublic_namesy5353
HGVSgchrI:g.12643049G>A
Sequence_detailsSMapS_parentSequencecb25.fpc4122
Flanking_sequencesaaaaggagaaggatggagtatcgaagaatgtgagattcaagacctatttttggggaaaaa
Mapping_targetcb25.fpc4122
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00036467
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis briggsae
StrainWBStrain00048094
LaboratoryPS
StatusLive
AffectsGeneWBGene00038147
TranscriptCBG18802.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScCBG18802.1:c.1093+1G>A
Intron_number7/10
InteractorWBInteraction000504429
WBInteraction000504430
WBInteraction000518852
WBInteraction000518874
WBInteraction000518875
DescriptionPhenotypeWBPhenotype:0000165Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
RemarkUninduced P7.p and P8.p in pry-1 mutants are frequently unfused. Also some cases of unfused P(9-11).p were observed in pry-1 mutants.Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBPhenotype:0000218Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
RemarkAnimals showed a high frequency of ectopically induced VPCs. Specifically, mid-L4 stage animals showed a unique defect in VPC induction pattern; P3.p, P4.p, and P8.p were ectopically induced in most animals whereas P7.p remained uninduced. In some cases only P5.p and P6.p were induced.Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBPhenotype:0000239Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
RemarkAll induced VPCs (except P6.p) adopted secondary cell fates. Four secondary lineage markers, namely egl-17::GFP (ayIs4), lin-11::GFP (syIs80),ceh-2::GFP (syIs54) (all mid/late-L4 stage) and dhs-31::GFP (syIs101)(old adult stage), were expressed in the progeny of all induced VPCs,P6.p excepted. The expression of primary lineage markers, egl-17::GFP (ayIs4) (early/mid-L3 stage), daf-6::YFP(bhEx53) and syg-2::GFP (wyEx3372) (both mid/late-L4 stage) was localized to P6.p progeny.Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBPhenotype:0000533Paper_evidenceWBPaper00041660
Curator_confirmedWBPerson712
RemarkSome of the Pn.p appeared small and morphologically similar to P12.pa.Paper_evidenceWBPaper00041660
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00041660
Curator_confirmedWBPerson712
WBPhenotype:0000962Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
Remarklip-1 reporter expression in Cbr-pry-1(sy5353) animals revealed a similar profile to controls but the fluorescence was much higher in P7.p and P8.p cells.Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBPhenotype:0001792Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
RemarkAll P(7-11).p cell nuclei were significantly smaller in size compared to wild type, appearing similar to P12.pa.Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006776PATO:0000460Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBbt:0006777PATO:0000460Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBbt:0006778PATO:0000460Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBbt:0006779PATO:0000460Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
WBbt:0004410PATO:0000460Paper_evidenceWBPaper00036467
Curator_confirmedWBPerson712
ReferenceWBPaper00036467
WBPaper00041660
MethodSubstitution_allele