WormBase Tree Display for Variation: WBVar00275574
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WBVar00275574 | Evidence | Paper_evidence | WBPaper00032136 | ||||||
---|---|---|---|---|---|---|---|---|---|
Name | Public_name | mgDf47 | |||||||
Sequence_details | Mapping_target | R13H8 | |||||||
Type_of_mutation | Deletion | ||||||||
SeqStatus | Pending_curation | ||||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00000265 | ||||||||
WBStrain00000266 | |||||||||
WBStrain00007897 | |||||||||
WBStrain00007908 | |||||||||
WBStrain00022168 | |||||||||
Laboratory | GR | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00000912 | |||||||
Interactor (87) | |||||||||
Description | Phenotype | WBPhenotype:0000062 | Paper_evidence | WBPaper00002914 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals are viable. | Paper_evidence | WBPaper00002914 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Temperature_sensitive | Heat_sensitive | 25 | Paper_evidence | WBPaper00002914 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000134 | Paper_evidence | WBPaper00032232 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Levels of sod-3, mtl-1 and F21F3.3 RNA expression were lower than that observed for wild-type animals. | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000731 | Paper_evidence | WBPaper00029085 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Increased levels of apoptosis in daf-16 loss-of-function mutants treated with IR | Paper_evidence | WBPaper00029085 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00029085 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006796 | PATO:0000460 | Paper_evidence | WBPaper00029085 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Life_stage | WBls:0000041 | PATO:0000460 | Paper_evidence | WBPaper00029085 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | Treated with 60 Gy IR | Paper_evidence | WBPaper00029085 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001090 | Paper_evidence | WBPaper00032232 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals died faster than wild-type animals when shifted to 35C. | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Adult animals were shifted to 35C and monitored for survival. | Paper_evidence | WBPaper00032232 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Temperature | 35 | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001171 | Paper_evidence | WBPaper00032232 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Lifespan was ~20% shorter than that of wild-type worms. | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001184 | Paper_evidence | WBPaper00032936 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | A small but significant elevation in BODIPY fat content was seen in daf-16/FOXO single mutants | Paper_evidence | WBPaper00032936 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | Staining with BODIPY-labeled fatty acid vital dye | Paper_evidence | WBPaper00032936 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_not_observed | WBPhenotype:0000460 | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Worms were sensitive to acute oxidative stress as assayed by treatment with a high-dose of paraquat. | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00002747 | Paper_evidence | WBPaper00032232 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | GO_term | GO:0034599 | PATO:0000460 | Paper_evidence | WBPaper00032232 | ||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Animals were assayed for survival in 200mM paraquat over time. | Paper_evidence | WBPaper00032232 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000631 | Paper_evidence | WBPaper00036280 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Life span was lengthened in response to trehalose, similar to N2 animals under the same conditions. | Paper_evidence | WBPaper00036280 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001653 | Paper_evidence | WBPaper00032232 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Worms responded similarly to wild-type animals to heavy metal stress, as assayed by exposure to cadmium. | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00032232 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003022 | Paper_evidence | WBPaper00032232 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Animals were assayed for survival in 18mM CdCl2 at 24 and 32 hours. | Paper_evidence | WBPaper00032232 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001765 | Paper_evidence | WBPaper00031935 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals showed carbon dioxide avoidance similar to wild-type animals. | Paper_evidence | WBPaper00031935 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00003023 | Paper_evidence | WBPaper00031935 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Strains were maintained at 22C. Animals were exposed to a 5% to 0% CO2 gradient. | Paper_evidence | WBPaper00031935 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001811 | Paper_evidence | WBPaper00031915 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Mutants were susceptible to the fat-reducing effects of exogenously administered serotonin | Paper_evidence | WBPaper00031915 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00031915 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Affected_by | Molecule | WBMol:00004929 | Paper_evidence | WBPaper00031915 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | Reduced fat content of 5-HT-treated animals was visualized by Nile red staining and confirmed by thin-layer chromatography (TLC) quantitation of total triglycerides extracted from vehicle- and 5-HT-treated worms and by Sudan black fat staining | Paper_evidence | WBPaper00031915 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Reference (13) | |||||||||
Method | Deletion_allele |