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WormBase Tree Display for Variation: WBVar00275574

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Name Class

WBVar00275574EvidencePaper_evidenceWBPaper00032136
NamePublic_namemgDf47
Sequence_detailsMapping_targetR13H8
Type_of_mutationDeletion
SeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000265
WBStrain00000266
WBStrain00007897
WBStrain00007908
WBStrain00022168
LaboratoryGR
StatusLive
AffectsGeneWBGene00000912
Interactor (87)
DescriptionPhenotypeWBPhenotype:0000062Paper_evidenceWBPaper00002914
Curator_confirmedWBPerson712
RemarkAnimals are viable.Paper_evidenceWBPaper00002914
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00002914
Curator_confirmedWBPerson712
WBPhenotype:0000134Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
RemarkLevels of sod-3, mtl-1 and F21F3.3 RNA expression were lower than that observed for wild-type animals.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
WBPhenotype:0000731Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
RemarkIncreased levels of apoptosis in daf-16 loss-of-function mutants treated with IRPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006796PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentTreated with 60 Gy IRPaper_evidenceWBPaper00029085
Curator_confirmedWBPerson2021
WBPhenotype:0001090Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
RemarkAnimals died faster than wild-type animals when shifted to 35C.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAdult animals were shifted to 35C and monitored for survival.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Temperature35Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
WBPhenotype:0001171Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
RemarkLifespan was ~20% shorter than that of wild-type worms.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
WBPhenotype:0001184Paper_evidenceWBPaper00032936
Curator_confirmedWBPerson2021
RemarkA small but significant elevation in BODIPY fat content was seen in daf-16/FOXO single mutantsPaper_evidenceWBPaper00032936
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentStaining with BODIPY-labeled fatty acid vital dyePaper_evidenceWBPaper00032936
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000460Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
RemarkWorms were sensitive to acute oxidative stress as assayed by treatment with a high-dose of paraquat.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002747Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
EQ_annotationsGO_termGO:0034599PATO:0000460Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were assayed for survival in 200mM paraquat over time.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
WBPhenotype:0000631Paper_evidenceWBPaper00036280
Curator_confirmedWBPerson712
RemarkLife span was lengthened in response to trehalose, similar to N2 animals under the same conditions.Paper_evidenceWBPaper00036280
Curator_confirmedWBPerson712
WBPhenotype:0001653Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
RemarkWorms responded similarly to wild-type animals to heavy metal stress, as assayed by exposure to cadmium.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003022Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were assayed for survival in 18mM CdCl2 at 24 and 32 hours.Paper_evidenceWBPaper00032232
Curator_confirmedWBPerson712
WBPhenotype:0001765Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
RemarkAnimals showed carbon dioxide avoidance similar to wild-type animals.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003023Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
Phenotype_assayTreatmentStrains were maintained at 22C. Animals were exposed to a 5% to 0% CO2 gradient.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
WBPhenotype:0001811Paper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
RemarkMutants were susceptible to the fat-reducing effects of exogenously administered serotoninPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00004929Paper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentReduced fat content of 5-HT-treated animals was visualized by Nile red staining and confirmed by thin-layer chromatography (TLC) quantitation of total triglycerides extracted from vehicle- and 5-HT-treated worms and by Sudan black fat stainingPaper_evidenceWBPaper00031915
Curator_confirmedWBPerson2021
Reference (13)
MethodDeletion_allele