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WormBase Tree Display for Variation: WBVar00275393

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Name Class

WBVar00275393NamePublic_nameye27
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00008568
LaboratoryHY
StatusLive
AffectsGeneWBGene00000269
DescriptionPhenotypeWBPhenotype:0001379Paper_evidenceWBPaper00034766
Curator_confirmedWBPerson2021
RemarkIn contrast to wt, induction of LEC-8::EGFP after exposure to Cry5B toxin was low in bre-4 mutantsPaper_evidenceWBPaper00034766
Curator_confirmedWBPerson2021
WBPhenotype:0001507Paper_evidenceWBPaper00034766
Curator_confirmedWBPerson2021
RemarkWhen bre mutant worms were fed E. coli expressing Cry5B, they did not exhibit toxic effects and remained alive under the same conditions in which wild-type worms had died.Paper_evidenceWBPaper00034766
Curator_confirmedWBPerson2021
WBPhenotype:0001524Paper_evidenceWBPaper00051118
Curator_confirmedWBPerson38423
RemarkLethargus duration increased by 23%; total sleep increased by 34%; Bout duration increased by 6% (Table 2A)Paper_evidenceWBPaper00051118
Curator_confirmedWBPerson38423
WBPhenotype:0002035Paper_evidenceWBPaper00039883
Curator_confirmedWBPerson9999
Remarkresistant to fruiting body lectin Marasmius oreades agglutinin (MOA, a Galα1,3Gal/GalNAc-specific lectin)Paper_evidenceWBPaper00039883
Curator_confirmedWBPerson9999
Affected_byMoleculeWBMol:00007870Paper_evidenceWBPaper00039883
Curator_confirmedWBPerson9999
WBPhenotype:0002060Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkProduces a brood when grown in the presence of Bt toxin Cry5B. The intestines of mutants fed Bt-produced toxin have intestinal morphology often indistinguishable from that of healthy wild-type intestine not exposed to toxin. Mutants are resistant to Cry5B-induced lethality. Unlike toxin-exposed wild-type animals, toxin-exposed mutants show only a modest reduction in fertility. Similar resistance is observed for animals exposed to E. coli produced Cry5B toxin. Mutants are similarly sensitive to Cry6A.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005329Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000072Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals appear morphologically normal.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000517Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals behave similarly to wild-type.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000673Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals have wild-type brood sizes.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000676Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals develop from embryos to adults at the normal wild-type rate.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
ReferenceWBPaper00039883
WBPaper00004264
WBPaper00034766
WBPaper00051118
MethodAllele