Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00275284

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00275284EvidencePaper_evidenceWBPaper00031432
NamePublic_namey1
Other_nameY39A1B.3.1:c.3365G>A
CE31734:p.Gly1122Glu
HGVSgCHROMOSOME_III:g.10771434G>A
Sequence_detailsSMapS_parentSequenceY39A1B
Flanking_sequencesaacggcttttcgtaccgaataagcttatgggcggcttctaccgattgtcgtttacgggat
Mapping_targetY39A1B
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00031432
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004578
WBStrain00035088
LaboratoryTY
StatusLive
AffectsGeneWBGene00001087
TranscriptY39A1B.3.1 (12)
InteractorWBInteraction000052060
GeneticsInterpolated_map_positionIII5.36471
Mapping_dataIn_multi_point1080
1081
1082
1083
2062
In_pos_neg_data2715
5727
5735
DescriptionPhenotypeWBPhenotype:0000032Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkat 24C, maternal effect dumpy/near lethal; XX viable at 15CPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive24Person_evidenceWBPerson261
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000066Paper_evidenceWBPaper00001077
WBPaper00001011
WBPaper00032450
Curator_confirmedWBPerson712
RemarkDosage compensation mutations cause XX specific maternal effect lethality.Paper_evidenceWBPaper00032450
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPaper_evidenceWBPaper00001077
WBPaper00001011
Curator_confirmedWBPerson712
Phenotype_assayGenotypedpy-28(y1);him-5Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0000583Paper_evidenceWBPaper00001077
WBPaper00001011
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals that escape lethality are Dpy.Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
at 24C, XX phenotype is zygotic weak dumpy, maternal effect dumpy/near lethalPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive24Person_evidenceWBPerson261
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_assayGenotypedpy-28(y1);him-5Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0000718Paper_evidenceWBPaper00001011
WBPaper00032450
Curator_confirmedWBPerson712
RemarkAs determined by the penetrance of the lin-14(n179) mutant phenotype, based on the [# mutant seam cell nuclei (undivided seam cell nuclei + nuclei that generated precocious alae)/ total # seam cell nuclei] animals after the L3 molt.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Dosage compensation mutations cause XX specific maternal effect lethality.Paper_evidenceWBPaper00032450
Curator_confirmedWBPerson712
Maternal
Phenotype_assayTreatmentNomarski optics were used to follow the fates of the midbody seam cell nuclei of L3 animals raised at 24C.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Temperature24Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBPhenotype:0000773Paper_evidenceWBPaper00032450
Curator_confirmedWBPerson712
RemarkHermaphrodite and male progeny of mutant mothers showed chromosome segregation defects in many tissues, whereas dpy-27 mutants did not (scored for gut nuclei; Figure S6B), confirming that condensin I promotes mitotic chromosome segregation.Paper_evidenceWBPaper00032450
Curator_confirmedWBPerson712
WBPhenotype:0001175Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkat 24C, XX phenotype is 3% Him, XX at 15C, 0.4% HimPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive24Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001581Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
RemarkAnimals have 36%(n=20) mutant seam cell nuclei, similar to XXX lin-14 animals (26% n=25) and less mutant than XX lin-14 animals (77% n=40).Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006913PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Life_stageWBls:0000035PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Phenotype_assayTreatmentNomarski optics were used to follow the fates of the midbody seam cell nuclei of L3 animals raised at 24C.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Temperature24Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBPhenotype:0001631Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
RemarkAnimals produce a very small number of nullo-X oocytes (0.5%).Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000928Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
RemarkPercent of lin-14 mutant seam cell nuclei in XO males is not different to that of males carrying lin-14 alone.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAll animals were raised at 20C.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Temperature20Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Genotypelin-14(n179)/0Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBPhenotype:0001021Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkXO phenotype wildtype male (ME3)Person_evidenceWBPerson261
Curator_confirmedWBPerson712
ReferenceWBPaper00013841
WBPaper00001077
WBPaper00013718
WBPaper00001011
WBPaper00016314
WBPaper00013715
WBPaper00032450
WBPaper00013717
WBPaper00015605
WBPaper00016421
MethodSubstitution_allele