WormBase Tree Display for Variation: WBVar00275208

WBVar00275208 Name: Public_name: x13
    Other_name: CE30706:p.Trp141Ter
      Y110A7A.3.1:c.422G>A
    HGVSg: CHROMOSOME_I:g.5143939G>A
  Sequence_details: SMap: S_parent: Sequence: Y110A7A
    Flanking_sequences: caaagctgacatataatggaacagttgaat ggcaccgcctgcgatctataaaaggtgaaa
    Mapping_target: Y110A7A
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00024268
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040919
    Laboratory: ZZ
    Status: Live
  Affects: Gene: WBGene00006797
    Transcript: Y110A7A.3.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: Y110A7A.3.1:c.422G>A
        HGVSp: CE30706:p.Trp141Ter
        cDNA_position: 428
        CDS_position: 422
        Protein_position: 141
        Exon_number: 5/12
        Codon_change: tGg/tAg
        Amino_acid_change: W/*
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00024268
  Genetics: Interpolated_map_position: I -0.354599
    Mapping_data: In_2_point: 209
        210
        410
        614
      In_multi_point: 245
  Description: Phenotype: WBPhenotype:0000017 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003650 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000421 Paper_evidence: WBPaper00000484
          WBPaper00035548
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00000484
              Person_evidence: WBPerson261
              Curator_confirmed: WBPerson2021
                WBPerson712
        Phenotype_assay: Treatment: 1mM levamisole Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000545 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: At 25C, x13 mutants have the unhealthy tendency to accumulate eggs. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00000484
          WBPaper00035548
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: No backward motion in L1 larvae. Newly hatched larvae can barely move forward. Adults have a mild Unc defect where the mutants move forward in a slow decayed sine wave. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00000484
                Curator_confirmed: WBPerson2021
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000484
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001005 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: poor backing Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001852 Paper_evidence: WBPaper00035074
        Curator_confirmed: WBPerson2021
        Remark: Mutants are resistant to tribendimidine Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000315 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0000478 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Mutants tend to remain within the borders of bacterial lawns as does the wild-type. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001084 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Attraction to sodium chloride is normal (See methods). Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001414 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
  Disease_info: Models_disease: DOID:1574
    Models_disease_in_annotation: WBDOannot00000706
  Reference: WBPaper00035548
    WBPaper00035074
    WBPaper00000484
    WBPaper00018321
    WBPaper00016087
  Method: Substitution_allele