WormBase Tree Display for Variation: WBVar00275173

WBVar00275173 Evidence: Paper_evidence: WBPaper00025090
  Name: Public_name: wk61
    Other_name: F58H12.1.1:c.820C>T
      CE28479:p.Gln274Ter
    HGVSg: CHROMOSOME_X:g.2849321G>A
  Sequence_details: SMap: S_parent: Sequence: F53B3
    Flanking_sequences: acacagatggatgcacatccgagatgatgtg aaaaaaatcaagcggcgcaactcctggaagc
    Mapping_target: F53B3
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00025090
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: LT
    Status: Live
  Affects: Gene: WBGene00002210
    Transcript: F58H12.1.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F58H12.1.1:c.820C>T
        HGVSp: CE28479:p.Gln274Ter
        cDNA_position: 871
        CDS_position: 820
        Protein_position: 274
        Exon_number: 9/18
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
    Interactor: WBInteraction000500840
      WBInteraction000502077
      WBInteraction000518519
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: X -12.6984
  Description: Phenotype: WBPhenotype:0000012 Paper_evidence: WBPaper00005858
        Curator_confirmed: WBPerson712
        Remark: Weak Daf-c. Paper_evidence: WBPaper00005858
            Curator_confirmed: WBPerson712
      WBPhenotype:0000031 Paper_evidence: WBPaper00025090
        Curator_confirmed: WBPerson2021
        Remark: kin-29 mutants grow more slowly than N2 Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000136 Paper_evidence: WBPaper00025090
        Curator_confirmed: WBPerson2021
        Remark: kin-29(wk61) animals show an increase in the expression level of the lon-1 transcript. kin-29 does not affect dbl-1 or sma-6 mRNA expression levels Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000154 Paper_evidence: WBPaper00025090
        Curator_confirmed: WBPerson2021
        Remark: kin-29(wk61) shows a brood size approximately 30% the size of that seen in wild-type animals Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000229 Paper_evidence: WBPaper00025090
          WBPaper00005858
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: kin-29(lf) animals are small. The Sma body size of kin-29 is due to a delay in development in later larval stages Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000070 Paper_evidence: WBPaper00005858
        Curator_confirmed: WBPerson712
      WBPhenotype:0000296 Paper_evidence: WBPaper00025090
        Curator_confirmed: WBPerson2021
        Remark: No crumpled spicules Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000297 Paper_evidence: WBPaper00025090
        Curator_confirmed: WBPerson2021
        Remark: kin-29 mutants do not display male tail ray fusions Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00025090
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00005858
    WBPaper00025090
  Method: Substitution_allele