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WormBase Tree Display for Variation: WBVar00266484

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Name Class

WBVar00266484EvidencePaper_evidenceWBPaper00005563
NamePublic_nametz2
Other_nameY41C4A.4a.1:c.858+3_*101del
Y41C4A.4g.1:c.1167+3_*101del
Y41C4A.4e.1:c.801+3_*101del
Y41C4A.4d.1:c.876+3_*101del
Y41C4A.4f.1:c.450+3_*101del
HGVSgCHROMOSOME_III:g.11692677_11693655del
Sequence_detailsSMapS_parentSequenceY41C4A
Flanking_sequencesagcgaaagagtgccgcagaaaaaagaaggtatttcctaatttttgaaagaaaaaaaattg
Mapping_targetY41C4A
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00040751
WBStrain00047812
LaboratoryYT
StatusLive
AffectsGeneWBGene00000793
TranscriptY41C4A.4e.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScY41C4A.4e.1:c.801+3_*101del
cDNA_position?-1082
Intron_number7/8
Exon_number8-9/9
Y41C4A.4g.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScY41C4A.4g.1:c.1167+3_*101del
cDNA_position?-1388
Intron_number5/6
Exon_number6-7/7
Y41C4A.4b.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number6/6
Exon_number7/7
Y41C4A.4a.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScY41C4A.4a.1:c.858+3_*101del
cDNA_position?-1181
Intron_number7/8
Exon_number8-9/9
Y41C4A.4d.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScY41C4A.4d.1:c.876+3_*101del
cDNA_position?-1197
Intron_number7/8
Exon_number8-9/9
Y41C4A.4f.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScY41C4A.4f.1:c.450+3_*101del
cDNA_position?-937
Intron_number4/5
Exon_number5-6/6
Y41C4A.4c.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number6/6
Exon_number7/7
InteractorWBInteraction000546931
GeneticsInterpolated_map_positionIII11.7926
DescriptionPhenotypeWBPhenotype:0000478Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
Remark17 deg C-cultivated crh-1(tz2) mutants migrated to colder regions; this behavior is similar wild-type animals; however, 23 and 20 deg C-cultivated crh-1(tz2) animals migrated towards colder regions than wild-type animals. | Expression of CRH-1 in AFD restores the behavioural defect of crh-1(tz2) mutants.Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
WBPhenotype:0000997Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
Remark17 deg C-cultivated crh-1(tz2) mutants migrated to colder regions; this behavior is similar wild-type animals; however, 23 and 20 deg C-cultivated crh-1(tz2) animals migrated towards colder regions than wild-type animals. | Expression of CRH-1 in AFD restores the behavioural defect of crh-1(tz2) mutants.Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
WBPhenotype:0000999Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
Remark17 deg C-cultivated crh-1(tz2) mutants migrated to colder regions; this behavior is similar wild-type animals; however, 23 and 20 deg C-cultivated crh-1(tz2) animals migrated towards colder regions than wild-type animals. | Expression of CRH-1 in AFD restores the behavioural defect of crh-1(tz2) mutants.Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
WBPhenotype:0001236Paper_evidenceWBPaper00049891
Curator_confirmedWBPerson10038
RemarkQuoted from paper: "We found that fluorescence of the glr-1 transcriptional reporter was increased in crh-1(tz2) loss-of-function mutants (Fig 3F), consistent with a role for CREB as a downstream target of CMK-1 in regulating glr-1transcription."Paper_evidenceWBPaper00049891
Curator_confirmedWBPerson10038
Phenotype_assayStrainWBStrain00047812Paper_evidenceWBPaper00049891
Curator_confirmedWBPerson10038
Control_strainWBStrain00047313Paper_evidenceWBPaper00049891
Curator_confirmedWBPerson10038
GenotypepzIs29 [Pglr-1::NLS-GFP::LacZ::unc-54 3'UTR]Paper_evidenceWBPaper00049891
Curator_confirmedWBPerson10038
WBPhenotype:0001785Paper_evidenceWBPaper00046360
WBPaper00040253
Curator_confirmedWBPerson3142
WBPerson1251
WBPhenotype:0002199Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
RemarkAFD neurons exhibit attenuation of calcium-concentration changes when cultivated at 20 and 23 deg C; the magnitude of calcium-concentration changes of AFD neurons in crh-1(tz2) mutants is significantly lower than that in wild-type animals.Paper_evidenceWBPaper00039855
Curator_confirmedWBPerson712
WBPhenotype:0002469Paper_evidenceWBPaper00039821
Curator_confirmedWBPerson5364
RemarkFigure 2, crh-1(tz2) mutant worms fail to form long-term memory of habituation training. Figure 4, rescuing crh-1(+) in the MAGI-1, but not MEC-4, expressing neurons rescues the long-term memory defects of crh-1(tz2) mutant worms.Paper_evidenceWBPaper00039821
Curator_confirmedWBPerson5364
WBPhenotype:0002567Paper_evidenceWBPaper00036296
Curator_confirmedWBPerson3142
RemarkThe cmk-1:crh-1β transgene rescues the long-term associative olfactory memory defect of crh-1(tz2) (Figure 3C)Paper_evidenceWBPaper00036296
Curator_confirmedWBPerson3142
Rescued_by_transgeneWBTransgene00026445
WBPhenotype:0002568Paper_evidenceWBPaper00041586
Curator_confirmedWBPerson10038
RemarkTable 1. Quoted from paper "crh-1 is required for long-term but not short-term memory for both associative and non-associative memory."Paper_evidenceWBPaper00041586
Curator_confirmedWBPerson10038
Phenotype_assayControl_strainWBStrain00000001Paper_evidenceWBPaper00041586
Curator_confirmedWBPerson10038
WBPhenotype:0002599Paper_evidenceWBPaper00041586
Curator_confirmedWBPerson10038
RemarkTable 1. Quoted from paper "crh-1 is required for long-term but not short-term memory for both associative and non-associative memory."Paper_evidenceWBPaper00041586
Curator_confirmedWBPerson10038
Phenotype_assayControl_strainWBStrain00000001Paper_evidenceWBPaper00041586
Curator_confirmedWBPerson10038
Phenotype_not_observedWBPhenotype:0002199Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
Remark"However, neither crh-1 mutants that lacked a C. elegans CREB homolog (Nishida et al., 2011) nor unc-43 mutants that lacked the C. elegans CaMKII ortholog (Reiner et al., 1999) showed a severe defect in the variable calcium response of AFD (Figure S2B)."Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005662PATO:0000460Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
Phenotype_assayGenotypenjIs24[gcy-8p::GCaMP3, gcy-8p::TagRFP] (I); Parent strain: IK0972Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
WBPhenotype:0002469Paper_evidenceWBPaper00039821
Curator_confirmedWBPerson5364
RemarkFigure 1, crh-1(tz2) mutant worms can habituate to repeated mechanosensory (tap) stimuliPaper_evidenceWBPaper00039821
Curator_confirmedWBPerson5364
ReferenceWBPaper00039821
WBPaper00039855
WBPaper00040253
WBPaper00010064
WBPaper00005563
WBPaper00036296
WBPaper00046360
WBPaper00049050
WBPaper00041586
WBPaper00049891
MethodDeletion_allele