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WormBase Tree Display for Variation: WBVar00252015

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Name Class

WBVar00252015NamePublic_nametm3287
Other_nameCE35990:p.Ala175IlefsTer9
K06A1.1.1:c.522_765del
HGVSgCHROMOSOME_II:g.6455588_6456054del
Sequence_detailsSMapS_parentSequenceK06A1
Flanking_sequencesaagctctacaactaaatatcgggttactgtcattcccgagaaattggaatctacttgaca
Mapping_targetK06A1
Source_location7CHROMOSOME_II64555876456055Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationDeletion
PCR_producttm3287_external
tm3287_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00008309
LaboratoryFX
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq3287
NBP_allele
StatusLive
AffectsGeneWBGene00019424
TranscriptK06A1.1.1 (11)
IsolationMutagenTMP/UV
GeneticsMapII
DescriptionPhenotypeWBPhenotype:0001524Paper_evidenceWBPaper00057148
Curator_confirmedWBPerson712
Remarkthese RIS-defective animals were strikingly defective in head movement quiescence and also showed rocking movements: alternating backward and forward body movements, each resulting in less than a half-body translation of the worm's position and virtually no net movement in either direction.Paper_evidenceWBPaper00057148
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as homozygous viable by the National Bioresource Project of Japan.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0001524Paper_evidenceWBPaper00057148
Curator_confirmedWBPerson712
Remarkaptf-1(lf) mutants greatly reduced their frequency of body bends during lethargus to a level similar to that of N2 controls.Paper_evidenceWBPaper00057148
Curator_confirmedWBPerson712
WBPhenotype:0002432Paper_evidenceWBPaper00057148
Curator_confirmedWBPerson712
RemarkIn contrast to ALA-defective animals, aptf-1(lf) mutants showed wild type body-bend quiescence during SIS; SIS body movement quiescence in aptf-1(lf) was similar to wild type, but took longer to set in in the case of UV-SIS (G). Body mobility was defined as a translation of the body position by at least 1/10 body length.Paper_evidenceWBPaper00057148
Curator_confirmedWBPerson712
We examined the behavior of aptf-1(lf) animals during SIS triggered by ultraviolet light (C) and by ingestion of pore-forming Cry5B toxin (D). As in lethargus, RIS-defective animals showed head movement, but they did not rock back and forth as they did during lethargus. Head mobility was defined as any discernible movement. Though head movement is often referred to as foraging behavior, we did not observe any feeding (pharyngeal pumping) in aptf-1 mutants in these assays.Paper_evidenceWBPaper00057148
Curator_confirmedWBPerson712
ReferenceWBPaper00057148
Remark14256/14257-14723/14724 (467 bp deletion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele