WormBase Tree Display for Variation: WBVar00251170

WBVar00251170 Name: Public_name: tm2256
    Other_name: T05D4.4a.1:c.601-51_680delinsTC
      T05D4.4b.1:c.601-51_680delinsTC
    HGVSg: CHROMOSOME_III:g.13577632_13577762delinsTC
  Sequence_details: SMap: S_parent: Sequence: T05D4
    Flanking_sequences: ttttctgacagtttgtgaattcaagaagta tccagttgtgcaaagattctgtaatccacc
    Mapping_target: T05D4
    Source_location: 7 CHROMOSOME_III 13577631 13577763 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Insertion: TC
      Deletion
    PCR_product: tm2256_external
      tm2256_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00008300
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 2256
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00003887
    Transcript: T05D4.4a.1 VEP_consequence: splice_acceptor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: T05D4.4a.1:c.601-51_680delinsTC
        cDNA_position: ?-702
        CDS_position: ?-680
        Protein_position: ?-227
        Intron_number: 4/13
        Exon_number: 5/14
      T05D4.4b.1 VEP_consequence: splice_acceptor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: T05D4.4b.1:c.601-51_680delinsTC
        cDNA_position: ?-680
        CDS_position: ?-680
        Protein_position: ?-227
        Intron_number: 3/9
        Exon_number: 4/10
    Interactor: WBInteraction000500645
      WBInteraction000500656
      WBInteraction000500658
      WBInteraction000500659
      WBInteraction000500660
  Isolation: Mutagen: TMP/UV
  Genetics: Map: III
  Description: Phenotype: WBPhenotype:0000315 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals had a lower arousal threshold to mechanosensory stimuli than control animals; animals responded more frequently to stimuli than control quiescent animals. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
      WBPhenotype:0000412 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals took significantly more time to respond to octanol (initiate backwards movement) than WT controls. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00001966 Paper_evidence: WBPaper00038400
              Curator_confirmed: WBPerson712
      WBPhenotype:0000641 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited increased basal locomotion activity, twice the number of body bends per minute than observed for control animals. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
      WBPhenotype:0001524 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited increased L4/A quiescence compared to control animals. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
      WBPhenotype:0000249 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson712
        Remark: Animals fail to avoid high osmolarity. Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson712
      WBPhenotype:0001096 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: ayIs4 Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson712
  Reference: WBPaper00038400
    WBPaper00032102
  Remark: 23507/23508-TC-23638/23639 (131 bp deletion + 2 bp insertion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele