WormBase Tree Display for Variation: WBVar00250787

WBVar00250787 Name: Public_name: tm1823
    Other_name: F36H2.1b.1:c.745_1067-102delinsTTGAATTTACCGC
      F36H2.1c.1:c.790_1112-102delinsTTGAATTTACCGC
      F36H2.1d.1:c.754_1076-102delinsTTGAATTTACCGC
      F36H2.1a.1:c.799_1121-102delinsTTGAATTTACCGC
    HGVSg: CHROMOSOME_I:g.9239348_9240064delinsGCGGTAAATTCAA
  Sequence_details: SMap: S_parent: Sequence: F36H2
    Flanking_sequences: tttcttttttttagcggtaaattcaaattg atcagcttcatttggaagatgttgggtatg
    Mapping_target: F36H2
    Source_location: 7 CHROMOSOME_I 9239347 9240065 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Insertion: GCGGTAAATTCAA
      Deletion
    PCR_product: tm1823_external
      tm1823_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 1823
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00009498
    Transcript: F36H2.1c.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F36H2.1c.1:c.790_1112-102delinsTTGAATTTACCGC
        cDNA_position: 862-?
        CDS_position: 790-?
        Protein_position: 264-?
        Intron_number: 4-5/11
        Exon_number: 4-5/12
      F36H2.1b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F36H2.1b.1:c.745_1067-102delinsTTGAATTTACCGC
        cDNA_position: 778-?
        CDS_position: 745-?
        Protein_position: 249-?
        Intron_number: 5-6/12
        Exon_number: 5-6/13
      F36H2.1a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F36H2.1a.1:c.799_1121-102delinsTTGAATTTACCGC
        cDNA_position: 871-?
        CDS_position: 799-?
        Protein_position: 267-?
        Intron_number: 4-5/11
        Exon_number: 4-5/12
      F36H2.1d.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: F36H2.1d.1:c.754_1076-102delinsTTGAATTTACCGC
        cDNA_position: 789-?
        CDS_position: 754-?
        Protein_position: 252-?
        Intron_number: 5-6/12
        Exon_number: 5-6/13
  Isolation: Mutagen: TMP/UV
  Genetics: Map: I
  Description: Phenotype: WBPhenotype:0000032 Paper_evidence: WBPaper00032450
        Curator_confirmed: WBPerson712
        Remark: Mutants are sick (data not shown). Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
      WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as lethal or sterile by the National Bioresource Project of Japan. Comment to the NBP from Dr. M. Han: Let and Ste. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
              MH
      WBPhenotype:0000230 Paper_evidence: WBPaper00032450
        Curator_confirmed: WBPerson712
        Remark: Mutants have withered tails (data not shown). Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00032450
        Curator_confirmed: WBPerson712
        Remark: Mutants become uncoordinated (data not shown). Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
          Homozygous adults mutant for each condensin II subunit exhibited abnormal connections between nuclei in late-dividing cell types such as ventral nerve cord, gut, and germline, which likely reflect failed mitotic chromosome segregation. Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00032450
        Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as lethal or sterile by the National Bioresource Project of Japan. Comment to the NBP from Dr. M. Han: Let and Ste. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
              MH
          Mutants become sterile adults (data not shown). Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
      WBPhenotype:0000697 Paper_evidence: WBPaper00032450
        Curator_confirmed: WBPerson712
        Remark: Mutants display protruding vulvae (data not shown). Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
      WBPhenotype:0000823 Paper_evidence: WBPaper00032450
        Curator_confirmed: WBPerson712
        Remark: The germline was extremely underproliferated and contained only a small patch of abnormal nuclei. Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
      WBPhenotype:0001378 Paper_evidence: WBPaper00032450
        Curator_confirmed: WBPerson712
        Remark: Homozygous adults mutant for each condensin II subunit exhibited abnormal connections between nuclei in late-dividing cell types such as ventral nerve cord, gut, and germline, which likely reflect failed mitotic chromosome segregation. Paper_evidence: WBPaper00032450
            Curator_confirmed: WBPerson712
  Reference: WBPaper00032450
  Remark: 3802/3803-GCGGTAAATTCAA-4519/4520 (717 bp deletion + 13 bp insertion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele