WormBase Tree Display for Variation: WBVar00250754

WBVar00250754 Name: Public_name: tm1789
    HGVSg: CHROMOSOME_II:g.5525057_5525978del
  Sequence_details: SMap: S_parent: Sequence: ZK177
    Flanking_sequences: ttatgatttgaaactttatcgtattcagtc gggtatacgctatacttatccagttcgaag
    Mapping_target: ZK177
    Source_location: 7 CHROMOSOME_II 5525056 5525979 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Deletion
    PCR_product: tm1789_external
      tm1789_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026697
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 1789
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00006554
    Transcript: ZK177.10.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: ?-293
        CDS_position: ?-275
        Protein_position: ?-92
        Intron_number: 2/5
        Exon_number: 1-3/6
    Interactor: WBInteraction000502409
      WBInteraction000502410
      WBInteraction000502411
      WBInteraction000542315
      WBInteraction000542316
      WBInteraction000542317
  Isolation: Mutagen: TMP/UV
  Genetics: Map: II
  Description: Phenotype: WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan. Comment to the NBP from Dr. M. Maduro: Development 133, 3097-3106 (2006). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000111 Paper_evidence: WBPaper00034727
        Curator_confirmed: WBPerson2021
        Remark: Absence of ceh-22::GFP expression in part of the posterior pharynx in tbx-35 mutants Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00034727
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000688 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan. Comment to the NBP from Dr. M. Maduro: Development 133, 3097-3106 (2006). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0001278 Paper_evidence: WBPaper00034727
        Curator_confirmed: WBPerson2021
        Remark: Weaker ceh-51 expression still occurred in approximately half of tbx-35(tm1789) mutants. In vivo expression of a minimal ceh-51::GFP reporter was abolished in a tbx-35(tm1789) background Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00034727
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001525 Paper_evidence: WBPaper00034727
        Curator_confirmed: WBPerson2021
        Remark: tbx-35(tm1789) larvae displayed grinder abnormalities and a defective terminal bulb at 15C. Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00034727
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 15C Paper_evidence: WBPaper00034727
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000493 Paper_evidence: WBPaper00034727
        Curator_confirmed: WBPerson2021
        Remark: tbx-35(tm1789) larvae showed a well-defined metacorpus Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00034727
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001046 Paper_evidence: WBPaper00034727
        Curator_confirmed: WBPerson2021
        Remark: tbx-35(tm1789) larvae showed less disorganized muscle actin Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034727
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00034727
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00034727
  Remark: 23636/23637-24558/24559 (922 bp deletion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele