WormBase Tree Display for Variation: WBVar00249278
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WBVar00249278 | Evidence | Person_evidence | WBPerson449 | ||||||
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Name | Public_name | tk27 | |||||||
Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Laboratory | NF | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00006876 | |||||||
Interactor | WBInteraction000501345 | ||||||||
WBInteraction000501346 | |||||||||
Description | Phenotype | WBPhenotype:0000154 | Paper_evidence | WBPaper00040080 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | tk27 hermaphrodites proliferated as homozygotes with small broods. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000188 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Mutants exhibited shortened gonad arms when compared with those in wild-type animals. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000195 | Paper_evidence | WBPaper00040080 | |||||||
Person_evidence | WBPerson449 | ||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson712 | |||||||||
Remark | The migration rate of DTCs was globally slower and the DTCs were arrested after the second turn, compared to controls. | In vab-10(tk27) animals, the migration of DTCs occurred essentially in a similar pattern to that of wild type, although the lamellipodial extension was not as extensive. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000425 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Both anti-VAB-10N and anti-VAB-10B detected signals in wild-type DTCs, but they failed to do so in tk27 DTCs. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006865 | PATO:0000460 | Paper_evidence | WBPaper00040080 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000511 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | The nuclear translocation of DTCs at the dorsal turn was suppressed in vab-10(tk27) mutants. | Nuclei stayed at the anterior or posterior ends rather than being relocated to the dorsal side of the DTCs, as in the wild type. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000691 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals with this mutation exhibited defects in gonad development. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000692 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Males were sterile (data not shown). | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001588 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In the vab-10(tk27) mutant, the array of MT filaments was severely disorganized, and the polarized localization of MTBD-Venus was completely lost. | Randomized patterns of shooting comets in both front and rear regions in the vab-10(tk27) DTCs were observed. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed | WBPhenotype:0000062 | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals did not exhibit any lethality. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000071 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals did not exhibit any head deformation. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001587 | Paper_evidence | WBPaper00040080 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Although the F-actin tended to be oriented along the anteroposterior axis before the dorsal turn, they came together to form thick bundles that surrounded the edges of the concave cell surface at the trailing end of the DTCs at the initiation of the dorsal turn. This bundling was also observed for F-actin in vab-10(tk27) animals. | Paper_evidence | WBPaper00040080 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00040080 | ||||||||
Method | Allele |