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WormBase Tree Display for Variation: WBVar00248956

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Name Class

WBVar00248956EvidencePaper_evidenceWBPaper00002543
NamePublic_namesy277
Other_nameY71F9B.5a.2:c.22_92del
CE25569:p.Ile8ArgfsTer3
Y71F9B.5a.1:c.22_92del
Y71F9B.5b.1:c.22_92del
CE28810:p.Ile8ArgfsTer3
HGVSgCHROMOSOME_I:g.2707650_2708127del
Sequence_detailsSMapS_parentSequenceY71F9B
Flanking_sequencesttctccaaaatgatgcattctttgggcatccgacattgagctatgcaaagacctgcccta
Mapping_targetY71F9B
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00030834
LaboratoryPS
StatusLive
AffectsGeneWBGene00003006
TranscriptY71F9B.5a.1 (11)
Y71F9B.5b.1 (11)
Y71F9B.5a.2 (11)
InteractorWBInteraction000002725
WBInteraction000538502
GeneticsInterpolated_map_positionI-7.44086
DescriptionPhenotypeWBPhenotype:0000220Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
RemarkVulva cell fate specification was abnormal as indicated by the expression patterns of the cdh-3::CFP and ceh-2::YFP transgenes (Figure 5)Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004448PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0004447PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0004436PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0004435PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0004434PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0004433PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0004432PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBPhenotype:0000257Paper_evidenceWBPaper00002543
Curator_confirmedWBPerson712
RemarkAdult hermaphrodites exhibited phasmid defects as assayed by DiO dye-filling.Paper_evidenceWBPaper00002543
Curator_confirmedWBPerson712
WBPhenotype:0000306Paper_evidenceWBPaper00005357
Curator_confirmedWBPerson2987
Remark"The analysis of the expression pattern of lin-11::GFP (syIs53) in lin-17(n671) animals showed a good correlation between the ectopic invagination of P7.p lineage cells (55%, n = 53) and their altered pattern of lin-11::GFP expression (47%, n = 36) (Figs. 4D, 4F, and 5A). In a wild-type animal at the Pn.pxx stage, syIs53 expression is typically detected in P5.ppx and P7.pax cells (Figs. 4A and 4B). However, in lin-17(n671) animals, the pattern of expression is defective in P7.p but not in P5.p progeny. The most frequent defect is a mirror image of the wild-type pattern in P7.p progeny (compare Fig. 4D with Fig. 4B). The other defect is either a graded (Figs. 4E and 4F) or uniform distribution (not shown) of GFP in all P7.p progeny. Very few worms had correctly localized GFP (<5%, n = 21)... Another allele of lin-17, sy277, shows similar effects (data not shown)."Paper_evidenceWBPaper00005357
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006895PATO:0000460Paper_evidenceWBPaper00005357
Curator_confirmedWBPerson2987
Phenotype_assayGenotypesyIs53 [lin-11::GFP]Paper_evidenceWBPaper00005357
Curator_confirmedWBPerson2987
WBPhenotype:0000510Paper_evidenceWBPaper00005357
Curator_confirmedWBPerson2987
Remark"The ectopic vulval invagination defect of lin-17(sy277) animals was completely suppressed by lin-11(n389) (n = 300; Table 1)."Paper_evidenceWBPaper00005357
Curator_confirmedWBPerson2987
WBPhenotype:0000695Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
RemarkFigure 5Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBPhenotype:0001968Paper_evidenceWBPaper00005116
Curator_confirmedWBPerson2987
RemarkTable 4Paper_evidenceWBPaper00005116
Curator_confirmedWBPerson2987
WBPhenotype:0002011Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
RemarkFigure 5Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBPhenotype:0002193Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
RemarkIn lin-17(sy277) mutants, P7.p daughters frequently displayed a greater amount of POP-1 protein in anterior daughter cell than posterior daughter cell, unlike wild type animals which usually display the opposite pattern (Table 1). The same deviant pattern occurred in P7.pa daughters and P7.pp daughters albeit with less penetrance.Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
"In wild type, vulA cells arise from the posterior daughter of P7.p (P7.pp). However, in lin-17(-), lin-18(-), and in double mutants, vulA cells most commonly arose from the anterior daughter of P7.p (P7.pa). This pattern of vulA specification suggests a reversal in the P7.p lineage at the first round of cell division." (Figure 5, Table 3)Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_term (12)
WBPhenotype:0002216Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
RemarkIn lin-17(sy277) mutants, P7.p daughters frequently displayed a greater amount of POP-1 protein in anterior daughter cell than posterior daughter cell, unlike wild type animals which usually display the opposite pattern (Table 1). The same deviant pattern occurred in P7.pa daughters and P7.pp daughters albeit with less penetrance.Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006983PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0007264PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0006984PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0007265PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0007266PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
WBbt:0004448PATO:0000460Paper_evidenceWBPaper00024693
Curator_confirmedWBPerson2987
ReferenceWBPaper00005357
WBPaper00005116
WBPaper00024693
WBPaper00002543
Remarksy277 starts 51 bp upstream of SL1 splice site and ends in the second exon 26 bp downstream of the splice acceptor site. Feature: WBsf000261 was used as a reference to curate this information.Paper_evidenceWBPaper00002543
Manually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00003006 Genomic_neighbourhoodPaper_evidenceWBPaper00002543
MethodDeletion_allele