WormBase Tree Display for Variation: WBVar00248886

WBVar00248886 Name: Public_name: sy10
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00030811
    Laboratory: PS
    Status: Live
  Affects: Gene: WBGene00002299
  Description: Phenotype: WBPhenotype:0000054 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: impenetrant larval lethal Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000062 Paper_evidence: WBPaper00001404
        Curator_confirmed: WBPerson712
        Remark: Identified in a noncomplementation screen with let-23(sy1) scoring for the Vulvaless phenotype. 15% or animals survive past the first larval stage; however these survivors are sterile. Paper_evidence: WBPaper00001404
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00001404
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001404
          Curator_confirmed: WBPerson712
      WBPhenotype:0000070 Paper_evidence: WBPaper00001404
        Curator_confirmed: WBPerson712
        Remark: Male tails displayed various defects. Paper_evidence: WBPaper00001404
            Curator_confirmed: WBPerson712
        Penetrance: Complete: Paper_evidence: WBPaper00001404
              Curator_confirmed: WBPerson712
      WBPhenotype:0000414 Paper_evidence: WBPaper00001404
        Curator_confirmed: WBPerson712
        Remark: P12 to P11 transformation is partly rescued maternally. Paper_evidence: WBPaper00001404
            Curator_confirmed: WBPerson712
          Animals have 90% wild-type P12 as homozygotes. Animals exhibit more P12-P11 cell transformations when in trans to sy12. Paper_evidence: WBPaper00001404
            Curator_confirmed: WBPerson712
        Penetrance: Complete: Paper_evidence: WBPaper00001404
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001404
          Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0004409 PATO:0000460 Paper_evidence: WBPaper00001404
                Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00001404
            Curator_confirmed: WBPerson712
      WBPhenotype:0000443 Paper_evidence: WBPaper00001404
        Curator_confirmed: WBPerson712
        Remark: Spicules exhibited various defects. Paper_evidence: WBPaper00001404
            Curator_confirmed: WBPerson712
        Penetrance: High: Paper_evidence: WBPaper00001404
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001404
          Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005312 PATO:0000460 Paper_evidence: WBPaper00001404
                Curator_confirmed: WBPerson712
      WBPhenotype:0000668 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Emo, abnormal oocytes Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00001404
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Surviving animals do not fertilize their oocytes, which subsequently degenerate in the uterus. Paper_evidence: WBPaper00001404
            Curator_confirmed: WBPerson712
          survivors sterile Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: Complete: Paper_evidence: WBPaper00001404
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001404
          Curator_confirmed: WBPerson712
      WBPhenotype:0000698 Paper_evidence: WBPaper00001404
        Curator_confirmed: WBPerson712
        Penetrance: Complete: Paper_evidence: WBPaper00001404
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001404
          Curator_confirmed: WBPerson712
      WBPhenotype:0001524 Paper_evidence: WBPaper00036308
        Curator_confirmed: WBPerson2987
        Remark: 94% of let-23(sy10) animals were resistant to EGF-induced sleep (Table 1) Paper_evidence: WBPaper00036308
            Curator_confirmed: WBPerson2987
        Penetrance: High: 94 Paper_evidence: WBPaper00036308
              Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Animals carrying the hs:LIN-3 transgene were well fed and grown at 20C. Young adult animals were scored 2 hours after heat shock for EGF-induced sleep behavior (see Materials and methods). Paper_evidence: WBPaper00036308
              Curator_confirmed: WBPerson2987
          Genotype: hs:LIN-3 Paper_evidence: WBPaper00036308
              Curator_confirmed: WBPerson2987
  Reference: WBPaper00022289
    WBPaper00036308
    WBPaper00012622
    WBPaper00015181
    WBPaper00001404
    WBPaper00021936
    WBPaper00014627
    WBPaper00013887
    WBPaper00022532
  Method: Allele