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WormBase Tree Display for Variation: WBVar00242654

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Name Class

WBVar00242654EvidencePaper_evidenceWBPaper00004448
NamePublic_namesb106
Other_nameCE08098:p.Arg117His
C10H11.9.1:c.350G>A
HGVSgCHROMOSOME_I:g.4743258C>T
Sequence_detailsSMapS_parentSequenceC10H11
Flanking_sequencesgagctgactctgcattcttctgggaggaactgatattatggctcacgcgaatagcgaatg
Mapping_targetC10H11
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryHR
StatusLive
AffectsGeneWBGene00002694
TranscriptC10H11.9.1 (12)
InteractorWBInteraction000501465
GeneticsInterpolated_map_positionI-0.750198
DescriptionPhenotypeWBPhenotype:0000052Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
RemarkAllele not as dominant-negative at 20 deg C.Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Variation_effectDominant_negative_gain_of_functionPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
MaternalStrictly_maternalPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
RemarkAt 20 deg C, let-502(sb106) mutants produced ~30 progeny/hermaphrodite, but brood size increased to ~150 progeny/hermaphrodite by outcross- ing to either wild-type or let-502(sb106) males. This suggests that let-502(sb106) sterility is due to the homozygous hermaphrodite having limited amounts of available sperm.Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
WBPhenotype:0000266Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
RemarkMutants displayed incompletely penetrant early cleavage defects. At 25 deg C, 58% of the progeny from let-502(sb106) homozygotes either failed to complete any cleavages or formed cleavage furrows that would then regress. All of the let-502(sb106) embryos that failed to hatch had cleavage defects and died prior to morphogenesis (n=20).Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Variation_effectDominant_negative_gain_of_functionPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
WBPhenotype:0000645Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
RemarkAllele not as dominant-negative at 20 deg C.Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Variation_effectDominant_negative_gain_of_functionPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
WBPhenotype:0000688Paper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Remarksterile, semi-sterile at 20 deg CPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Variation_effectDominant_negative_gain_of_functionPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPaper_evidenceWBPaper00004448
Curator_confirmedWBPerson712
ReferenceWBPaper00026257
WBPaper00004448
MethodSubstitution_allele